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Apolipoprotein B-100 kinetics and static plasma indices of triglyceride-rich lipoprotein metabolism in overweight men.
Clin Biochem. 2005 Sep; 38(9):806-12.CB

Abstract

OBJECTIVE

We examined the association of plasma apolipoprotein (apoB) B-48, remnant-like particle (RLP)-cholesterol and non-HDL cholesterol concentrations with apoB-100 kinetics in overweight-obese men.

METHODS AND RESULTS

Very-low density lipoprotein (VLDL), intermediate-density lipoprotein (IDL) and low-density lipoprotein (LDL) apoB-100 kinetics were measured in 53 men (BMI 33 +/- 4 kg/m(2)) using stable isotopes and multicompartmental modeling to estimate production rate (PR) and fractional catabolic rate (FCR). Fasting apoB-48 and RLP-cholesterol concentrations were measured using immunoassays. In univariate regression, apoB-48 and RLP-cholesterol were inversely associated with VLDL-apoB-100 FCR and IDL-apoB-100 FCR (P < 0.01 for all), but not with VLDL-, IDL- and LDL-apoB-100 PRs. Plasma non-HDL-cholesterol concentration was significantly and positively associated with the secretion rate of VLDL-apoB-100 (P < 0.05), and inversely correlated with the FCR of LDL-apoB-100 (P < 0.01).

CONCLUSIONS

Our findings suggest that in overweight-obese men plasma concentrations of apoB-48, RLP-cholesterol and non-HDL-cholesterol are partly dependent on catabolism of apoB-100 containing lipoproteins.

Authors+Show Affiliations

School of Medicine and Pharmacology, University of Western Australia, GPO Box X2213, Perth, WA 6847, Australia. dcfchan@cyllene.uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15992790

Citation

Chan, Dick C., et al. "Apolipoprotein B-100 Kinetics and Static Plasma Indices of Triglyceride-rich Lipoprotein Metabolism in Overweight Men." Clinical Biochemistry, vol. 38, no. 9, 2005, pp. 806-12.
Chan DC, Watts GF, Ng TW, et al. Apolipoprotein B-100 kinetics and static plasma indices of triglyceride-rich lipoprotein metabolism in overweight men. Clin Biochem. 2005;38(9):806-12.
Chan, D. C., Watts, G. F., Ng, T. W., Uchida, Y., Sakai, N., Yamashita, S., & Barrett, P. H. (2005). Apolipoprotein B-100 kinetics and static plasma indices of triglyceride-rich lipoprotein metabolism in overweight men. Clinical Biochemistry, 38(9), 806-12.
Chan DC, et al. Apolipoprotein B-100 Kinetics and Static Plasma Indices of Triglyceride-rich Lipoprotein Metabolism in Overweight Men. Clin Biochem. 2005;38(9):806-12. PubMed PMID: 15992790.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein B-100 kinetics and static plasma indices of triglyceride-rich lipoprotein metabolism in overweight men. AU - Chan,Dick C, AU - Watts,Gerald F, AU - Ng,Theodore W K, AU - Uchida,Yoshiaki, AU - Sakai,Naohiko, AU - Yamashita,Shizuya, AU - Barrett,P Hugh R, PY - 2005/02/20/received PY - 2005/05/26/revised PY - 2005/05/26/accepted PY - 2005/7/5/pubmed PY - 2006/9/22/medline PY - 2005/7/5/entrez SP - 806 EP - 12 JF - Clinical biochemistry JO - Clin Biochem VL - 38 IS - 9 N2 - OBJECTIVE: We examined the association of plasma apolipoprotein (apoB) B-48, remnant-like particle (RLP)-cholesterol and non-HDL cholesterol concentrations with apoB-100 kinetics in overweight-obese men. METHODS AND RESULTS: Very-low density lipoprotein (VLDL), intermediate-density lipoprotein (IDL) and low-density lipoprotein (LDL) apoB-100 kinetics were measured in 53 men (BMI 33 +/- 4 kg/m(2)) using stable isotopes and multicompartmental modeling to estimate production rate (PR) and fractional catabolic rate (FCR). Fasting apoB-48 and RLP-cholesterol concentrations were measured using immunoassays. In univariate regression, apoB-48 and RLP-cholesterol were inversely associated with VLDL-apoB-100 FCR and IDL-apoB-100 FCR (P < 0.01 for all), but not with VLDL-, IDL- and LDL-apoB-100 PRs. Plasma non-HDL-cholesterol concentration was significantly and positively associated with the secretion rate of VLDL-apoB-100 (P < 0.05), and inversely correlated with the FCR of LDL-apoB-100 (P < 0.01). CONCLUSIONS: Our findings suggest that in overweight-obese men plasma concentrations of apoB-48, RLP-cholesterol and non-HDL-cholesterol are partly dependent on catabolism of apoB-100 containing lipoproteins. SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/15992790/Apolipoprotein_B_100_kinetics_and_static_plasma_indices_of_triglyceride_rich_lipoprotein_metabolism_in_overweight_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(05)00153-0 DB - PRIME DP - Unbound Medicine ER -