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Epinephrine-induced excitation and sensitization of rat C-fiber nociceptors.
J Pain. 2005 Jul; 6(7):439-46.JP

Abstract

Although epinephrine (EPI) has been suggested to contribute to the pain and hyperalgesia associated with inflammation and nerve injury, there have been very few in vivo electrophysiologic studies of the effects of EPI on nociceptors. We found with the single-unit recording technique that the intradermal administration of EPI resulted in excitation of a group of C fibers and a decrease in the mechanical activation threshold in a non-overlapping group. Unexpectedly, the fibers that were neither excited nor demonstrated a decrease in threshold demonstrated as a group a significant increase in response to sustained suprathreshold mechanical stimuli, an effect not observed in the other 2 groups of C fibers. This identifies a novel response of C-fiber nociceptors to an inflammatory mediator and suggests it is present in a class of C fibers previously considered unresponsive to hyperalgesic inflammatory mediators.

PERSPECTIVE

Our study provides support for the suggestion that EPI, a neuroendocrine stress hormone as well as an inflammatory mediator, might contribute to pain syndromes, especially in the setting of chronic stress.

Authors+Show Affiliations

Department of Anatomy, Division of Neuroscience, NIH Pain Center, University of California, San Francisco, California 94143, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15993822

Citation

Chen, Xiaojie, and Jon D. Levine. "Epinephrine-induced Excitation and Sensitization of Rat C-fiber Nociceptors." The Journal of Pain : Official Journal of the American Pain Society, vol. 6, no. 7, 2005, pp. 439-46.
Chen X, Levine JD. Epinephrine-induced excitation and sensitization of rat C-fiber nociceptors. J Pain. 2005;6(7):439-46.
Chen, X., & Levine, J. D. (2005). Epinephrine-induced excitation and sensitization of rat C-fiber nociceptors. The Journal of Pain : Official Journal of the American Pain Society, 6(7), 439-46.
Chen X, Levine JD. Epinephrine-induced Excitation and Sensitization of Rat C-fiber Nociceptors. J Pain. 2005;6(7):439-46. PubMed PMID: 15993822.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Epinephrine-induced excitation and sensitization of rat C-fiber nociceptors. AU - Chen,Xiaojie, AU - Levine,Jon D, PY - 2004/09/13/received PY - 2005/02/02/revised PY - 2005/02/16/accepted PY - 2005/7/5/pubmed PY - 2005/9/9/medline PY - 2005/7/5/entrez SP - 439 EP - 46 JF - The journal of pain : official journal of the American Pain Society JO - J Pain VL - 6 IS - 7 N2 - UNLABELLED: Although epinephrine (EPI) has been suggested to contribute to the pain and hyperalgesia associated with inflammation and nerve injury, there have been very few in vivo electrophysiologic studies of the effects of EPI on nociceptors. We found with the single-unit recording technique that the intradermal administration of EPI resulted in excitation of a group of C fibers and a decrease in the mechanical activation threshold in a non-overlapping group. Unexpectedly, the fibers that were neither excited nor demonstrated a decrease in threshold demonstrated as a group a significant increase in response to sustained suprathreshold mechanical stimuli, an effect not observed in the other 2 groups of C fibers. This identifies a novel response of C-fiber nociceptors to an inflammatory mediator and suggests it is present in a class of C fibers previously considered unresponsive to hyperalgesic inflammatory mediators. PERSPECTIVE: Our study provides support for the suggestion that EPI, a neuroendocrine stress hormone as well as an inflammatory mediator, might contribute to pain syndromes, especially in the setting of chronic stress. SN - 1526-5900 UR - https://www.unboundmedicine.com/medline/citation/15993822/Epinephrine_induced_excitation_and_sensitization_of_rat_C_fiber_nociceptors_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1526-5900(05)00452-9 DB - PRIME DP - Unbound Medicine ER -