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An interaction between the TaqIB polymorphism of cholesterol ester transfer protein and smoking is associated with changes in plasma high-density lipoprotein cholesterol levels in Turks.
Clin Genet. 2005 Aug; 68(2):118-27.CG

Abstract

Low levels of high-density lipoprotein cholesterol (HDL-C) are an independent risk factor for atherosclerosis. We investigated the effects of the TaqIB polymorphism of cholesterol ester transfer protein (CETP) on CETP activity and plasma HDL-C levels in random nondiabetic and self-reported diabetic subjects in a population with very low HDL-C levels. The rare B2B2 genotype was associated with significantly higher HDL-C levels and lower CETP activity in random subjects and with higher HDL-C in diabetic subjects. After stratification of random subjects by smoking status, the common B1B1 genotype was associated with lower HDL-C levels than the B2B2 genotype. Although smoking was associated with lower HDL-C, especially in men, HDL-C levels between smokers and nonsmokers were not different in subjects with the B1B2 or B2B2 genotypes. However, smoking (20+ cigarettes/day) was associated with a marked reduction in HDL-C in the B1B1 subjects. The B1B1/smoking interaction was not reflected in a difference in CETP activity. High triglycerides and elevated body mass index (BMI) lower HDL-C. The B2B2 genotype was associated with the highest HDL-C levels, and these levels were significantly lower in the hypertriglyceridemic subjects (>or=50th percentile). The lowest HDL-C levels were seen in hypertriglyceridemic subjects with the B1B1 genotype. Although BMI (>or=50th vs<50th percentile) did not affect HDL-C in B2B2 subjects, a high BMI was associated with markedly lower HDL-C in B1B1 subjects. Thus, HDL-C levels in Turks may be modulated by an interaction between the CETP TaqIB polymorphism and smoking, as well as an interaction with hypertriglyceridemia and BMI.

Authors+Show Affiliations

Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15996208

Citation

Hodoğlugil, U, et al. "An Interaction Between the TaqIB Polymorphism of Cholesterol Ester Transfer Protein and Smoking Is Associated With Changes in Plasma High-density Lipoprotein Cholesterol Levels in Turks." Clinical Genetics, vol. 68, no. 2, 2005, pp. 118-27.
Hodoğlugil U, Williamson DW, Huang Y, et al. An interaction between the TaqIB polymorphism of cholesterol ester transfer protein and smoking is associated with changes in plasma high-density lipoprotein cholesterol levels in Turks. Clin Genet. 2005;68(2):118-27.
Hodoğlugil, U., Williamson, D. W., Huang, Y., & Mahley, R. W. (2005). An interaction between the TaqIB polymorphism of cholesterol ester transfer protein and smoking is associated with changes in plasma high-density lipoprotein cholesterol levels in Turks. Clinical Genetics, 68(2), 118-27.
Hodoğlugil U, et al. An Interaction Between the TaqIB Polymorphism of Cholesterol Ester Transfer Protein and Smoking Is Associated With Changes in Plasma High-density Lipoprotein Cholesterol Levels in Turks. Clin Genet. 2005;68(2):118-27. PubMed PMID: 15996208.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An interaction between the TaqIB polymorphism of cholesterol ester transfer protein and smoking is associated with changes in plasma high-density lipoprotein cholesterol levels in Turks. AU - Hodoğlugil,U, AU - Williamson,D W, AU - Huang,Y, AU - Mahley,R W, PY - 2005/7/6/pubmed PY - 2005/9/15/medline PY - 2005/7/6/entrez SP - 118 EP - 27 JF - Clinical genetics JO - Clin Genet VL - 68 IS - 2 N2 - Low levels of high-density lipoprotein cholesterol (HDL-C) are an independent risk factor for atherosclerosis. We investigated the effects of the TaqIB polymorphism of cholesterol ester transfer protein (CETP) on CETP activity and plasma HDL-C levels in random nondiabetic and self-reported diabetic subjects in a population with very low HDL-C levels. The rare B2B2 genotype was associated with significantly higher HDL-C levels and lower CETP activity in random subjects and with higher HDL-C in diabetic subjects. After stratification of random subjects by smoking status, the common B1B1 genotype was associated with lower HDL-C levels than the B2B2 genotype. Although smoking was associated with lower HDL-C, especially in men, HDL-C levels between smokers and nonsmokers were not different in subjects with the B1B2 or B2B2 genotypes. However, smoking (20+ cigarettes/day) was associated with a marked reduction in HDL-C in the B1B1 subjects. The B1B1/smoking interaction was not reflected in a difference in CETP activity. High triglycerides and elevated body mass index (BMI) lower HDL-C. The B2B2 genotype was associated with the highest HDL-C levels, and these levels were significantly lower in the hypertriglyceridemic subjects (>or=50th percentile). The lowest HDL-C levels were seen in hypertriglyceridemic subjects with the B1B1 genotype. Although BMI (>or=50th vs<50th percentile) did not affect HDL-C in B2B2 subjects, a high BMI was associated with markedly lower HDL-C in B1B1 subjects. Thus, HDL-C levels in Turks may be modulated by an interaction between the CETP TaqIB polymorphism and smoking, as well as an interaction with hypertriglyceridemia and BMI. SN - 0009-9163 UR - https://www.unboundmedicine.com/medline/citation/15996208/An_interaction_between_the_TaqIB_polymorphism_of_cholesterol_ester_transfer_protein_and_smoking_is_associated_with_changes_in_plasma_high_density_lipoprotein_cholesterol_levels_in_Turks_ L2 - https://doi.org/10.1111/j.1399-0004.2005.00467.x DB - PRIME DP - Unbound Medicine ER -