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Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant.
Am J Transplant. 2005 Aug; 5(8):2031-6.AJ

Abstract

Community-acquired viral respiratory tract infections (RTI) in lung transplant recipients may have a high rate of progression to pneumonia and can be a trigger for immunologically mediated detrimental effects on lung function. A cohort of 100 patients was enrolled from 2001 to 2003 in which 50 patients had clinically diagnosed viral RTI and 50 were asymptomatic. All patients had nasopharyngeal and throat swabs taken for respiratory virus antigen detection, culture and RT-PCR. All patients had pulmonary function tests at regular intervals for 12 months. Rates of rejection, decline in forced expiratory volume (L) in 1 s (FEV-1) and bacterial and fungal superinfection were compared at the 3-month primary endpoint. In the 50 patients with RTI, a microbial etiology was identified in 33 of 50 (66%) and included rhinovirus (9), coronavirus (8), RSV (6), influenza A (5), parainfluenza (4) and human metapneumovirus (1). During the 3-month primary endpoint, 8 of 50 (16%) RTI patients had acute rejection versus 0 of 50 non-RTI patients (p=0.006). The number of patients experiencing a 20% or more decline in FEV-1 by 3 months was 9 of 50 (18%) RTI versus 0 of 50 non-RTI (0%) (p=0.003). In six of these nine patients, the decline in FEV-1 was sustained over a 1-year period consistent with bronchiolitis obliterans syndrome (BOS). Community-acquired respiratory viruses may be associated with the development of acute rejection and BOS.

Authors+Show Affiliations

Infectious Diseases & Multi-organ Transplant, University of Toronto, Toronto, Ontario, Canada. deepali.kumar@uhn.on.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15996256

Citation

Kumar, Deepali, et al. "Clinical Impact of Community-acquired Respiratory Viruses On Bronchiolitis Obliterans After Lung Transplant." American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, vol. 5, no. 8, 2005, pp. 2031-6.
Kumar D, Erdman D, Keshavjee S, et al. Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant. Am J Transplant. 2005;5(8):2031-6.
Kumar, D., Erdman, D., Keshavjee, S., Peret, T., Tellier, R., Hadjiliadis, D., Johnson, G., Ayers, M., Siegal, D., & Humar, A. (2005). Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 5(8), 2031-6.
Kumar D, et al. Clinical Impact of Community-acquired Respiratory Viruses On Bronchiolitis Obliterans After Lung Transplant. Am J Transplant. 2005;5(8):2031-6. PubMed PMID: 15996256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical impact of community-acquired respiratory viruses on bronchiolitis obliterans after lung transplant. AU - Kumar,Deepali, AU - Erdman,Dean, AU - Keshavjee,Shaf, AU - Peret,Teresa, AU - Tellier,Raymond, AU - Hadjiliadis,Denis, AU - Johnson,Grant, AU - Ayers,Melissa, AU - Siegal,Deborah, AU - Humar,Atul, PY - 2005/7/6/pubmed PY - 2005/10/5/medline PY - 2005/7/6/entrez SP - 2031 EP - 6 JF - American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons JO - Am. J. Transplant. VL - 5 IS - 8 N2 - Community-acquired viral respiratory tract infections (RTI) in lung transplant recipients may have a high rate of progression to pneumonia and can be a trigger for immunologically mediated detrimental effects on lung function. A cohort of 100 patients was enrolled from 2001 to 2003 in which 50 patients had clinically diagnosed viral RTI and 50 were asymptomatic. All patients had nasopharyngeal and throat swabs taken for respiratory virus antigen detection, culture and RT-PCR. All patients had pulmonary function tests at regular intervals for 12 months. Rates of rejection, decline in forced expiratory volume (L) in 1 s (FEV-1) and bacterial and fungal superinfection were compared at the 3-month primary endpoint. In the 50 patients with RTI, a microbial etiology was identified in 33 of 50 (66%) and included rhinovirus (9), coronavirus (8), RSV (6), influenza A (5), parainfluenza (4) and human metapneumovirus (1). During the 3-month primary endpoint, 8 of 50 (16%) RTI patients had acute rejection versus 0 of 50 non-RTI patients (p=0.006). The number of patients experiencing a 20% or more decline in FEV-1 by 3 months was 9 of 50 (18%) RTI versus 0 of 50 non-RTI (0%) (p=0.003). In six of these nine patients, the decline in FEV-1 was sustained over a 1-year period consistent with bronchiolitis obliterans syndrome (BOS). Community-acquired respiratory viruses may be associated with the development of acute rejection and BOS. SN - 1600-6135 UR - https://www.unboundmedicine.com/medline/citation/15996256/Clinical_impact_of_community_acquired_respiratory_viruses_on_bronchiolitis_obliterans_after_lung_transplant_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1600-6135&date=2005&volume=5&issue=8&spage=2031 DB - PRIME DP - Unbound Medicine ER -