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New prenylated benzoic acid derivatives of Piper hispidum.
Pharmazie. 2005 Jun; 60(6):455-7.P

Abstract

Three new 4-hydroxy-benzoic acid derivatives, 4-methoxy-3,5-bis-(3-hydroxy-3-methyl-1-butenyl)benzoate, 3-hydroxy-2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-5-carboxylic acid, and 3-hydroxy-2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-5-carboxylic acid methyl ester together with eight known compounds, have been isolated from the stems of Piper hispidum. Their structures were elucidated by a detailed spectroscopic analysis. In addition, the cytotoxicity of seven isolated compounds has been evaluated, revealing a moderate activity for three derivatives of dillapiole.

Authors+Show Affiliations

Friedrich U
Institut für Pharmazie (Pharmazeutische Biologie), Freie Universität Berlin, Berlin.
Siems K
No affiliation info available
Solis PN
No affiliation info available
Gupta MP
No affiliation info available
Jenett-Siems K
No affiliation info available

MeSH

Antineoplastic Agents, PhytogenicBenzoatesCell Line, TumorHumansLatin AmericaMagnetic Resonance SpectroscopyPiperPlant ExtractsPlant LeavesProtein Prenylation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15997836

Citation

Friedrich, U, et al. "New Prenylated Benzoic Acid Derivatives of Piper Hispidum." Die Pharmazie, vol. 60, no. 6, 2005, pp. 455-7.
Friedrich U, Siems K, Solis PN, et al. New prenylated benzoic acid derivatives of Piper hispidum. Pharmazie. 2005;60(6):455-7.
Friedrich, U., Siems, K., Solis, P. N., Gupta, M. P., & Jenett-Siems, K. (2005). New prenylated benzoic acid derivatives of Piper hispidum. Die Pharmazie, 60(6), 455-7.
Friedrich U, et al. New Prenylated Benzoic Acid Derivatives of Piper Hispidum. Pharmazie. 2005;60(6):455-7. PubMed PMID: 15997836.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - New prenylated benzoic acid derivatives of Piper hispidum. AU - Friedrich,U, AU - Siems,K, AU - Solis,P N, AU - Gupta,M P, AU - Jenett-Siems,K, PY - 2005/7/7/pubmed PY - 2005/8/24/medline PY - 2005/7/7/entrez SP - 455 EP - 7 JF - Die Pharmazie JO - Pharmazie VL - 60 IS - 6 N2 - Three new 4-hydroxy-benzoic acid derivatives, 4-methoxy-3,5-bis-(3-hydroxy-3-methyl-1-butenyl)benzoate, 3-hydroxy-2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-5-carboxylic acid, and 3-hydroxy-2-(1-hydroxy-1-methylethyl)-2,3-dihydrobenzofuran-5-carboxylic acid methyl ester together with eight known compounds, have been isolated from the stems of Piper hispidum. Their structures were elucidated by a detailed spectroscopic analysis. In addition, the cytotoxicity of seven isolated compounds has been evaluated, revealing a moderate activity for three derivatives of dillapiole. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/15997836/New_prenylated_benzoic_acid_derivatives_of_Piper_hispidum_ DB - PRIME DP - Unbound Medicine ER -