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Lesions of the dorsal hippocampus block trace fear conditioned potentiation of startle.
Behav Neurosci. 2005 Jun; 119(3):834-8.BN

Abstract

Several studies show that the hippocampus is critical for the memories mediating trace and contextual fear conditioning. This study investigates whether N-methyl-D-aspartate-induced lesions of the dorsal hippocampus made prior to training affect context fear conditioning and trace fear conditioning measured with the fear-potentiated startle. Pretraining excitotoxic lesions of the dorsal hippocampus blocked acquisition of trace fear conditioning to a tone stimulus but did not affect context fear conditioning. These data indicate that without a dorsal hippocampus rats are unable to acquire trace conditioning but can acquire contextual fear when fear is measured by potentiation of the startle response.

Authors+Show Affiliations

Fendt M
Fakultät für Biologie, Universität [corrected] Tübingen, Tübingen, Germany. markus.fendt@uni-tuebingen.de
Fanselow MS
No affiliation info available
Koch M
No affiliation info available

MeSH

Acoustic StimulationAnalysis of VarianceAnimalsBehavior, AnimalBrain DiseasesConditioning, PsychologicalFearHippocampusMaleN-MethylaspartateRatsRats, Sprague-DawleyReflex, StartleTime Factors

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15998205

Citation

Fendt, Markus, et al. "Lesions of the Dorsal Hippocampus Block Trace Fear Conditioned Potentiation of Startle." Behavioral Neuroscience, vol. 119, no. 3, 2005, pp. 834-8.
Fendt M, Fanselow MS, Koch M. Lesions of the dorsal hippocampus block trace fear conditioned potentiation of startle. Behav Neurosci. 2005;119(3):834-8.
Fendt, M., Fanselow, M. S., & Koch, M. (2005). Lesions of the dorsal hippocampus block trace fear conditioned potentiation of startle. Behavioral Neuroscience, 119(3), 834-8.
Fendt M, Fanselow MS, Koch M. Lesions of the Dorsal Hippocampus Block Trace Fear Conditioned Potentiation of Startle. Behav Neurosci. 2005;119(3):834-8. PubMed PMID: 15998205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lesions of the dorsal hippocampus block trace fear conditioned potentiation of startle. AU - Fendt,Markus, AU - Fanselow,Michael S, AU - Koch,Michael, PY - 2005/7/7/pubmed PY - 2005/10/12/medline PY - 2005/7/7/entrez SP - 834 EP - 8 JF - Behavioral neuroscience JO - Behav Neurosci VL - 119 IS - 3 N2 - Several studies show that the hippocampus is critical for the memories mediating trace and contextual fear conditioning. This study investigates whether N-methyl-D-aspartate-induced lesions of the dorsal hippocampus made prior to training affect context fear conditioning and trace fear conditioning measured with the fear-potentiated startle. Pretraining excitotoxic lesions of the dorsal hippocampus blocked acquisition of trace fear conditioning to a tone stimulus but did not affect context fear conditioning. These data indicate that without a dorsal hippocampus rats are unable to acquire trace conditioning but can acquire contextual fear when fear is measured by potentiation of the startle response. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/15998205/Lesions_of_the_dorsal_hippocampus_block_trace_fear_conditioned_potentiation_of_startle_ DB - PRIME DP - Unbound Medicine ER -