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Combined efficacies of DL-alpha-lipoic acid and meso 2,3 dimercaptosuccinic acid against arsenic induced toxicity in antioxidant systems of rats.
Toxicol Lett. 2005 Dec 30; 160(1):1-7.TL

Abstract

Health hazards caused by heavy metals have become a great concern to the population. Arsenic as an environmental agent is considered to be a toxic substance due to its carcinogenic potential in humans. Since arsenic compounds might exert their toxicity by the generation of reactive oxygen species, we have evaluated the effect of both DL-alpha-lipoic acid (LA) and meso 2,3 dimercapto succinic acid (DMSA) on the antioxidants and lipid peroxidation in arsenic treated rats. The objective of the study was to determine whether DL-alpha-lipoic acid and meso 2,3 dimercapto succinic acid could rehabitate antioxidant depletion and damage to biomolecules in protection against oxidative insults. A significant increase in the levels of reactive oxygen species formation and lipid peroxidation and decrease in the activities of antioxidant enzymes were observed in arsenic exposed rats. Supplementation of DL-alpha-lipoic acid and meso 2,3 dimercapto succinic acid to arsenic fed rats significantly increased the activities of superoxide dismutase, catalase, glutathione peroxidase with elevation in the levels of reduced glutathione, total sulfhydryl, ascorbic acid and alpha-tocopherol. In addition, significant decrease in the levels of reactive oxygen species formation and lipid peroxidation was also observed in our study. From our results, we conclude that DL-alpha-lipoic acid and meso 2,3 dimercapto succinic acid play a synergistic role in decreasing arsenic induced oxidative damage by elevating the antioxidant status in liver and kidney.

Authors+Show Affiliations

Department of Medical Biochemistry, Dr. AL Mudaliar Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai 600113, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15998567

Citation

Kokilavani, Vedagiri, et al. "Combined Efficacies of DL-alpha-lipoic Acid and Meso 2,3 Dimercaptosuccinic Acid Against Arsenic Induced Toxicity in Antioxidant Systems of Rats." Toxicology Letters, vol. 160, no. 1, 2005, pp. 1-7.
Kokilavani V, Devi MA, Sivarajan K, et al. Combined efficacies of DL-alpha-lipoic acid and meso 2,3 dimercaptosuccinic acid against arsenic induced toxicity in antioxidant systems of rats. Toxicol Lett. 2005;160(1):1-7.
Kokilavani, V., Devi, M. A., Sivarajan, K., & Panneerselvam, C. (2005). Combined efficacies of DL-alpha-lipoic acid and meso 2,3 dimercaptosuccinic acid against arsenic induced toxicity in antioxidant systems of rats. Toxicology Letters, 160(1), 1-7.
Kokilavani V, et al. Combined Efficacies of DL-alpha-lipoic Acid and Meso 2,3 Dimercaptosuccinic Acid Against Arsenic Induced Toxicity in Antioxidant Systems of Rats. Toxicol Lett. 2005 Dec 30;160(1):1-7. PubMed PMID: 15998567.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined efficacies of DL-alpha-lipoic acid and meso 2,3 dimercaptosuccinic acid against arsenic induced toxicity in antioxidant systems of rats. AU - Kokilavani,Vedagiri, AU - Devi,Muthuswamy Anusuya, AU - Sivarajan,Kumarasamy, AU - Panneerselvam,Chinnakkannu, Y1 - 2005/07/05/ PY - 2005/02/09/received PY - 2005/05/30/revised PY - 2005/05/30/accepted PY - 2005/7/7/pubmed PY - 2005/12/16/medline PY - 2005/7/7/entrez SP - 1 EP - 7 JF - Toxicology letters JO - Toxicol Lett VL - 160 IS - 1 N2 - Health hazards caused by heavy metals have become a great concern to the population. Arsenic as an environmental agent is considered to be a toxic substance due to its carcinogenic potential in humans. Since arsenic compounds might exert their toxicity by the generation of reactive oxygen species, we have evaluated the effect of both DL-alpha-lipoic acid (LA) and meso 2,3 dimercapto succinic acid (DMSA) on the antioxidants and lipid peroxidation in arsenic treated rats. The objective of the study was to determine whether DL-alpha-lipoic acid and meso 2,3 dimercapto succinic acid could rehabitate antioxidant depletion and damage to biomolecules in protection against oxidative insults. A significant increase in the levels of reactive oxygen species formation and lipid peroxidation and decrease in the activities of antioxidant enzymes were observed in arsenic exposed rats. Supplementation of DL-alpha-lipoic acid and meso 2,3 dimercapto succinic acid to arsenic fed rats significantly increased the activities of superoxide dismutase, catalase, glutathione peroxidase with elevation in the levels of reduced glutathione, total sulfhydryl, ascorbic acid and alpha-tocopherol. In addition, significant decrease in the levels of reactive oxygen species formation and lipid peroxidation was also observed in our study. From our results, we conclude that DL-alpha-lipoic acid and meso 2,3 dimercapto succinic acid play a synergistic role in decreasing arsenic induced oxidative damage by elevating the antioxidant status in liver and kidney. SN - 0378-4274 UR - https://www.unboundmedicine.com/medline/citation/15998567/Combined_efficacies_of_DL_alpha_lipoic_acid_and_meso_23_dimercaptosuccinic_acid_against_arsenic_induced_toxicity_in_antioxidant_systems_of_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-4274(05)00164-5 DB - PRIME DP - Unbound Medicine ER -