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Effect of soybean protein on blood pressure: a randomized, controlled trial.

Abstract

BACKGROUND

Epidemiologic studies suggest that vegetable protein intake is inversely related to blood pressure.

OBJECTIVE

To examine the effect of soybean protein supplementation on blood pressure in persons with prehypertension or stage 1 hypertension.

DESIGN

Randomized, double-blind, controlled trial.

SETTING

Three communities in the People's Republic of China.

PATIENTS

302 participants 35 to 64 years of age with an initial untreated systolic blood pressure of 130 to 159 mm Hg, diastolic blood pressure of 80 to 99 mm Hg, or both.

INTERVENTION

Study participants were randomly assigned to receive 40 g of isolated soybean protein supplements per day or complex carbohydrate control for 12 weeks; 91.4% completed the intervention.

MEASUREMENTS

Blood pressure measurements were obtained by using random-zero sphygmomanometers at baseline and at 6 and 12 weeks.

RESULTS

At baseline, the mean systolic and diastolic blood pressures were 135.0 mm Hg (SD 10.9) and 84.7 mm Hg (SD 6.9), respectively. Compared with the control group, the net changes in systolic blood pressure and diastolic blood pressure were -4.31 mm Hg (95% CI, -2.11 to -6.51 mm Hg; P < 0.001) and -2.76 mm Hg (CI, -1.35 to -4.16 mm Hg; P < 0.001), respectively, after the 12-week intervention. The net changes in systolic and diastolic blood pressure reductions were -7.88 mm Hg (CI, -4.66 to -11.1 mm Hg) and -5.27 mm Hg (CI, -3.05 to -7.49 mm Hg), respectively, in persons with hypertension and -2.34 mm Hg (CI, 0.48 to -5.17 mm Hg) and -1.28 mm Hg (CI, 0.52 to -3.07 mm Hg), respectively, in those without hypertension.

LIMITATIONS

This trial did not examine whether the blood pressure reduction was due to protein or isoflavones in soybean.

CONCLUSIONS

Soybean protein supplementation resulted in a reduction in systolic and diastolic blood pressure. These findings suggest that increased intake of soybean protein may play an important role in preventing and treating hypertension.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, 1430 Tulane Avenue, SL 18, New Orleans, LA 70112-2699, USA. jhe@tulane.edu

    , , , , ,

    Source

    Annals of internal medicine 143:1 2005 Jul 05 pg 1-9

    MeSH

    Adult
    Aged
    Blood Pressure
    Body Weight
    China
    Dietary Carbohydrates
    Dietary Supplements
    Double-Blind Method
    Female
    Humans
    Hypertension
    Male
    Middle Aged
    Potassium
    Sodium
    Soybean Proteins

    Pub Type(s)

    Clinical Trial
    Journal Article
    Multicenter Study
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15998749

    Citation

    He, Jiang, et al. "Effect of Soybean Protein On Blood Pressure: a Randomized, Controlled Trial." Annals of Internal Medicine, vol. 143, no. 1, 2005, pp. 1-9.
    He J, Gu D, Wu X, et al. Effect of soybean protein on blood pressure: a randomized, controlled trial. Ann Intern Med. 2005;143(1):1-9.
    He, J., Gu, D., Wu, X., Chen, J., Duan, X., Chen, J., & Whelton, P. K. (2005). Effect of soybean protein on blood pressure: a randomized, controlled trial. Annals of Internal Medicine, 143(1), pp. 1-9.
    He J, et al. Effect of Soybean Protein On Blood Pressure: a Randomized, Controlled Trial. Ann Intern Med. 2005 Jul 5;143(1):1-9. PubMed PMID: 15998749.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of soybean protein on blood pressure: a randomized, controlled trial. AU - He,Jiang, AU - Gu,Dongfeng, AU - Wu,Xigui, AU - Chen,Jichun, AU - Duan,Xiufang, AU - Chen,Jing, AU - Whelton,Paul K, PY - 2005/7/7/pubmed PY - 2005/7/16/medline PY - 2005/7/7/entrez SP - 1 EP - 9 JF - Annals of internal medicine JO - Ann. Intern. Med. VL - 143 IS - 1 N2 - BACKGROUND: Epidemiologic studies suggest that vegetable protein intake is inversely related to blood pressure. OBJECTIVE: To examine the effect of soybean protein supplementation on blood pressure in persons with prehypertension or stage 1 hypertension. DESIGN: Randomized, double-blind, controlled trial. SETTING: Three communities in the People's Republic of China. PATIENTS: 302 participants 35 to 64 years of age with an initial untreated systolic blood pressure of 130 to 159 mm Hg, diastolic blood pressure of 80 to 99 mm Hg, or both. INTERVENTION: Study participants were randomly assigned to receive 40 g of isolated soybean protein supplements per day or complex carbohydrate control for 12 weeks; 91.4% completed the intervention. MEASUREMENTS: Blood pressure measurements were obtained by using random-zero sphygmomanometers at baseline and at 6 and 12 weeks. RESULTS: At baseline, the mean systolic and diastolic blood pressures were 135.0 mm Hg (SD 10.9) and 84.7 mm Hg (SD 6.9), respectively. Compared with the control group, the net changes in systolic blood pressure and diastolic blood pressure were -4.31 mm Hg (95% CI, -2.11 to -6.51 mm Hg; P < 0.001) and -2.76 mm Hg (CI, -1.35 to -4.16 mm Hg; P < 0.001), respectively, after the 12-week intervention. The net changes in systolic and diastolic blood pressure reductions were -7.88 mm Hg (CI, -4.66 to -11.1 mm Hg) and -5.27 mm Hg (CI, -3.05 to -7.49 mm Hg), respectively, in persons with hypertension and -2.34 mm Hg (CI, 0.48 to -5.17 mm Hg) and -1.28 mm Hg (CI, 0.52 to -3.07 mm Hg), respectively, in those without hypertension. LIMITATIONS: This trial did not examine whether the blood pressure reduction was due to protein or isoflavones in soybean. CONCLUSIONS: Soybean protein supplementation resulted in a reduction in systolic and diastolic blood pressure. These findings suggest that increased intake of soybean protein may play an important role in preventing and treating hypertension. SN - 1539-3704 UR - https://www.unboundmedicine.com/medline/citation/15998749/full_citation L2 - https://www.annals.org/article.aspx?volume=143&amp;issue=1&amp;page=1 DB - PRIME DP - Unbound Medicine ER -