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A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control.
J Clin Endocrinol Metab. 2005 Sep; 90(9):5241-6.JC

Abstract

CONTEXT

Previous studies using pancreatic polypeptide (PP) infusions in humans have failed to show an effect on gastric emptying, glucose metabolism, and insulin secretion. This might be due to the use of nonhuman sequences of the peptide.

OBJECTIVE

The objective of this study was to use synthetic human PP to study gastric emptying rates of a solid meal and postprandial hormone secretion and glucose disposal as well as the gastric emptying rate of water.

DESIGN

This was a single-blind study.

SETTING

The study was performed at a university hospital.

PARTICIPANTS

Fourteen healthy adult subjects were studied.

INTERVENTIONS

Infusion of saline or PP at 0.75 or 2.25 pmol/kg.min was given to eight subjects (gastric emptying of solid food), and infusion of saline or PP at 2.25 pmol/kg.min was given to six subjects (gastric emptying of water).

MAIN OUTCOME MEASURES

The main outcome measures were gastric emptying of solids (scintigraphy), hunger ratings (visual analog scale), and plasma concentrations of PP, insulin, glucagon, somatostatin, glucagon-like peptide 1, glucose, and gastric emptying of plain water (scintigraphy).

RESULTS

PP prolonged the lag phase and the half-time of emptying of the solid meal. The change in hunger rating, satiety, desire to eat after the meal, or prospective consumption was not affected. The postprandial rise in plasma glucose was prolonged by PP. The postprandial rise in insulin was also delayed by PP. PP had no significant effect on the emptying of water.

CONCLUSIONS

PP inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. PP is suggested to have a physiological role in the pancreatic postprandial counterregulation of gastric emptying and insulin secretion.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Karolinska University Hospital, Solna, SE-171 76 Stockholm, Sweden. peter.thelin.schmidt@medks.ki.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15998783

Citation

Schmidt, P T., et al. "A Role for Pancreatic Polypeptide in the Regulation of Gastric Emptying and Short-term Metabolic Control." The Journal of Clinical Endocrinology and Metabolism, vol. 90, no. 9, 2005, pp. 5241-6.
Schmidt PT, Näslund E, Grybäck P, et al. A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control. J Clin Endocrinol Metab. 2005;90(9):5241-6.
Schmidt, P. T., Näslund, E., Grybäck, P., Jacobsson, H., Holst, J. J., Hilsted, L., & Hellström, P. M. (2005). A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control. The Journal of Clinical Endocrinology and Metabolism, 90(9), 5241-6.
Schmidt PT, et al. A Role for Pancreatic Polypeptide in the Regulation of Gastric Emptying and Short-term Metabolic Control. J Clin Endocrinol Metab. 2005;90(9):5241-6. PubMed PMID: 15998783.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A role for pancreatic polypeptide in the regulation of gastric emptying and short-term metabolic control. AU - Schmidt,P T, AU - Näslund,E, AU - Grybäck,P, AU - Jacobsson,H, AU - Holst,J J, AU - Hilsted,L, AU - Hellström,P M, Y1 - 2005/07/05/ PY - 2005/7/7/pubmed PY - 2005/10/7/medline PY - 2005/7/7/entrez SP - 5241 EP - 6 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 90 IS - 9 N2 - CONTEXT: Previous studies using pancreatic polypeptide (PP) infusions in humans have failed to show an effect on gastric emptying, glucose metabolism, and insulin secretion. This might be due to the use of nonhuman sequences of the peptide. OBJECTIVE: The objective of this study was to use synthetic human PP to study gastric emptying rates of a solid meal and postprandial hormone secretion and glucose disposal as well as the gastric emptying rate of water. DESIGN: This was a single-blind study. SETTING: The study was performed at a university hospital. PARTICIPANTS: Fourteen healthy adult subjects were studied. INTERVENTIONS: Infusion of saline or PP at 0.75 or 2.25 pmol/kg.min was given to eight subjects (gastric emptying of solid food), and infusion of saline or PP at 2.25 pmol/kg.min was given to six subjects (gastric emptying of water). MAIN OUTCOME MEASURES: The main outcome measures were gastric emptying of solids (scintigraphy), hunger ratings (visual analog scale), and plasma concentrations of PP, insulin, glucagon, somatostatin, glucagon-like peptide 1, glucose, and gastric emptying of plain water (scintigraphy). RESULTS: PP prolonged the lag phase and the half-time of emptying of the solid meal. The change in hunger rating, satiety, desire to eat after the meal, or prospective consumption was not affected. The postprandial rise in plasma glucose was prolonged by PP. The postprandial rise in insulin was also delayed by PP. PP had no significant effect on the emptying of water. CONCLUSIONS: PP inhibits gastric emptying of solid food and delays the postprandial rise in plasma glucose and insulin. PP is suggested to have a physiological role in the pancreatic postprandial counterregulation of gastric emptying and insulin secretion. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/15998783/A_role_for_pancreatic_polypeptide_in_the_regulation_of_gastric_emptying_and_short_term_metabolic_control_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2004-2089 DB - PRIME DP - Unbound Medicine ER -