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Highly pathogenic H5N1 influenza virus infection in migratory birds.
Science. 2005 Aug 19; 309(5738):1206.Sci

Abstract

H5N1 avian influenza virus (AIV) has emerged as a pathogenic entity for a variety of species, including humans, in recent years. Here we report an outbreak among migratory birds on Lake Qinghaihu, China, in May and June 2005, in which more than a thousand birds were affected. Pancreatic necrosis and abnormal neurological symptoms were the major clinical features. Sequencing of the complete genomes of four H5N1 AIV strains revealed them to be reassortants related to a peregrine falcon isolate from Hong Kong and to have known highly pathogenic characteristics. Experimental animal infections reproduced typical highly pathogenic AIV infection symptoms and pathology.

Authors+Show Affiliations

College of Veterinary Medicine, China Agricultural University, Beijing 100094, China. jhl@cau.edu.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16000410

Citation

Liu, J, et al. "Highly Pathogenic H5N1 Influenza Virus Infection in Migratory Birds." Science (New York, N.Y.), vol. 309, no. 5738, 2005, p. 1206.
Liu J, Xiao H, Lei F, et al. Highly pathogenic H5N1 influenza virus infection in migratory birds. Science. 2005;309(5738):1206.
Liu, J., Xiao, H., Lei, F., Zhu, Q., Qin, K., Zhang, X. W., Zhang, X. L., Zhao, D., Wang, G., Feng, Y., Ma, J., Liu, W., Wang, J., & Gao, G. F. (2005). Highly pathogenic H5N1 influenza virus infection in migratory birds. Science (New York, N.Y.), 309(5738), 1206.
Liu J, et al. Highly Pathogenic H5N1 Influenza Virus Infection in Migratory Birds. Science. 2005 Aug 19;309(5738):1206. PubMed PMID: 16000410.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Highly pathogenic H5N1 influenza virus infection in migratory birds. AU - Liu,J, AU - Xiao,H, AU - Lei,F, AU - Zhu,Q, AU - Qin,K, AU - Zhang,X-W, AU - Zhang,X-L, AU - Zhao,D, AU - Wang,G, AU - Feng,Y, AU - Ma,J, AU - Liu,W, AU - Wang,J, AU - Gao,G F, Y1 - 2005/07/06/ PY - 2005/7/8/pubmed PY - 2005/9/1/medline PY - 2005/7/8/entrez SP - 1206 EP - 1206 JF - Science (New York, N.Y.) JO - Science VL - 309 IS - 5738 N2 - H5N1 avian influenza virus (AIV) has emerged as a pathogenic entity for a variety of species, including humans, in recent years. Here we report an outbreak among migratory birds on Lake Qinghaihu, China, in May and June 2005, in which more than a thousand birds were affected. Pancreatic necrosis and abnormal neurological symptoms were the major clinical features. Sequencing of the complete genomes of four H5N1 AIV strains revealed them to be reassortants related to a peregrine falcon isolate from Hong Kong and to have known highly pathogenic characteristics. Experimental animal infections reproduced typical highly pathogenic AIV infection symptoms and pathology. SN - 1095-9203 UR - https://www.unboundmedicine.com/medline/citation/16000410/Highly_pathogenic_H5N1_influenza_virus_infection_in_migratory_birds_ L2 - https://www.sciencemag.org/cgi/pmidlookup?view=long&pmid=16000410 DB - PRIME DP - Unbound Medicine ER -