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Modulatory effect of cadmium exposure on deltamethrin-induced oxidative stress in Channa punctata Bloch.
Arch Environ Contam Toxicol. 2005 Oct; 49(3):371-7.AE

Abstract

The modulatory effect of cadmium pretreatment (0.2 mg/kg b.w. i.p.) on deltamethrin-induced oxidative stress and alterations of antioxidants was studied in freshwater fish Channa punctata Bloch. Lipid peroxidation (LPO) was measured as one of the indicators of oxidative stress. Activities of glutathione peroxidase, glutathione reductase, and glutathione-S-transferase were also studied in liver, kidney, and gills. Levels of reduced glutathione (GSH) were measured in various tissues. Fish pretreated with cadmium and subsequently exposed to deltamethrin showed significantly reduced LPO values when compared with deltamethrin-exposed fish. Conversely, in the kidney, a potentiation response was observed. Deltamethrin exposure in fish resulted in significant alteration in activities of glutathione-dependent antioxidant enzymes. In the cadmium preexposed fish, which were subsequently exposed to deltamethrin, antioxidant enzymes showed a tendency toward normalization over deltamethrin-only exposed fish in liver and gills. GSH also showed a similar pattern in liver and gills but in kidney it remained elevated. Cadmium alone had no significant effect on various parameters at the concentration used in this study. When metallothionein (MT) induction was studied, only liver showed an MT-like protein band in sodium dodecylsulfate-polyacrylamide gel electrophoresis analysis. These results demonstrate a modulatory role of cadmium on the oxidative stress and other related parameters in liver and gills. These findings are important in the context of exposure to a mixture of pollutants in aquatic environment.

Authors+Show Affiliations

Ecotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi 110 062, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16001157

Citation

Atif, F, et al. "Modulatory Effect of Cadmium Exposure On Deltamethrin-induced Oxidative Stress in Channa Punctata Bloch." Archives of Environmental Contamination and Toxicology, vol. 49, no. 3, 2005, pp. 371-7.
Atif F, Parvez S, Pandey S, et al. Modulatory effect of cadmium exposure on deltamethrin-induced oxidative stress in Channa punctata Bloch. Arch Environ Contam Toxicol. 2005;49(3):371-7.
Atif, F., Parvez, S., Pandey, S., Ali, M., Kaur, M., Rehman, H., Khan, H. A., & Raisuddin, S. (2005). Modulatory effect of cadmium exposure on deltamethrin-induced oxidative stress in Channa punctata Bloch. Archives of Environmental Contamination and Toxicology, 49(3), 371-7.
Atif F, et al. Modulatory Effect of Cadmium Exposure On Deltamethrin-induced Oxidative Stress in Channa Punctata Bloch. Arch Environ Contam Toxicol. 2005;49(3):371-7. PubMed PMID: 16001157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulatory effect of cadmium exposure on deltamethrin-induced oxidative stress in Channa punctata Bloch. AU - Atif,F, AU - Parvez,S, AU - Pandey,S, AU - Ali,M, AU - Kaur,M, AU - Rehman,H, AU - Khan,H A, AU - Raisuddin,S, Y1 - 2005/07/06/ PY - 2004/11/02/received PY - 2004/08/20/accepted PY - 2005/7/8/pubmed PY - 2005/11/4/medline PY - 2005/7/8/entrez SP - 371 EP - 7 JF - Archives of environmental contamination and toxicology JO - Arch Environ Contam Toxicol VL - 49 IS - 3 N2 - The modulatory effect of cadmium pretreatment (0.2 mg/kg b.w. i.p.) on deltamethrin-induced oxidative stress and alterations of antioxidants was studied in freshwater fish Channa punctata Bloch. Lipid peroxidation (LPO) was measured as one of the indicators of oxidative stress. Activities of glutathione peroxidase, glutathione reductase, and glutathione-S-transferase were also studied in liver, kidney, and gills. Levels of reduced glutathione (GSH) were measured in various tissues. Fish pretreated with cadmium and subsequently exposed to deltamethrin showed significantly reduced LPO values when compared with deltamethrin-exposed fish. Conversely, in the kidney, a potentiation response was observed. Deltamethrin exposure in fish resulted in significant alteration in activities of glutathione-dependent antioxidant enzymes. In the cadmium preexposed fish, which were subsequently exposed to deltamethrin, antioxidant enzymes showed a tendency toward normalization over deltamethrin-only exposed fish in liver and gills. GSH also showed a similar pattern in liver and gills but in kidney it remained elevated. Cadmium alone had no significant effect on various parameters at the concentration used in this study. When metallothionein (MT) induction was studied, only liver showed an MT-like protein band in sodium dodecylsulfate-polyacrylamide gel electrophoresis analysis. These results demonstrate a modulatory role of cadmium on the oxidative stress and other related parameters in liver and gills. These findings are important in the context of exposure to a mixture of pollutants in aquatic environment. SN - 0090-4341 UR - https://www.unboundmedicine.com/medline/citation/16001157/Modulatory_effect_of_cadmium_exposure_on_deltamethrin_induced_oxidative_stress_in_Channa_punctata_Bloch_ L2 - https://dx.doi.org/10.1007/s00244-003-9231-4 DB - PRIME DP - Unbound Medicine ER -