Tags

Type your tag names separated by a space and hit enter

In vivo chloroquine resistance and prevalence of the pfcrt codon 76 mutation in Plasmodium falciparum isolates from the Republic of Congo.
Acta Trop. 2005 Sep; 95(3):219-25.AT

Abstract

Chloroquine (CQ) resistance in Plasmodium falciparum has been particularly associated with mutations in the pfcrt gene. The present study was carried out in the malaria hyperendemic town of Brazzaville (Republic of Congo, Central Africa) where CQ is still recommended and used as a first-line drug for P. falciparum malaria. We assessed the efficacy of CQ in vivo, and the association between pfcrt mutation at codon 76 and treatment outcome in 50 children with uncomplicated malaria. The failure rate on day 28 was 95.7% and the pfcrt K76T mutation was present in 100% of isolates. No variation in the multiplicity of infection was observed in pre- and post-treatment isolates. In further 87 isolates from uncomplicated patients not treated with CQ, the mutation was detected in 98.5% of isolates. This study confirms the high level of in vivo resistance to CQ and shows the high prevalence of pfcrt K76T mutation in the Republic of Congo.

Authors+Show Affiliations

Albert Schweitzer Hospital, BP 118, Lambaréné, Gabon.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16002038

Citation

Mayengue, Pembe Issamou, et al. "In Vivo Chloroquine Resistance and Prevalence of the Pfcrt Codon 76 Mutation in Plasmodium Falciparum Isolates From the Republic of Congo." Acta Tropica, vol. 95, no. 3, 2005, pp. 219-25.
Mayengue PI, Ndounga M, Davy MM, et al. In vivo chloroquine resistance and prevalence of the pfcrt codon 76 mutation in Plasmodium falciparum isolates from the Republic of Congo. Acta Trop. 2005;95(3):219-25.
Mayengue, P. I., Ndounga, M., Davy, M. M., Tandou, N., & Ntoumi, F. (2005). In vivo chloroquine resistance and prevalence of the pfcrt codon 76 mutation in Plasmodium falciparum isolates from the Republic of Congo. Acta Tropica, 95(3), 219-25.
Mayengue PI, et al. In Vivo Chloroquine Resistance and Prevalence of the Pfcrt Codon 76 Mutation in Plasmodium Falciparum Isolates From the Republic of Congo. Acta Trop. 2005;95(3):219-25. PubMed PMID: 16002038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vivo chloroquine resistance and prevalence of the pfcrt codon 76 mutation in Plasmodium falciparum isolates from the Republic of Congo. AU - Mayengue,Pembe Issamou, AU - Ndounga,Mathieu, AU - Davy,Matondo Maya, AU - Tandou,Ntsonde, AU - Ntoumi,Francine, PY - 2005/03/03/received PY - 2005/05/30/revised PY - 2005/06/06/accepted PY - 2005/7/9/pubmed PY - 2005/10/13/medline PY - 2005/7/9/entrez SP - 219 EP - 25 JF - Acta tropica JO - Acta Trop VL - 95 IS - 3 N2 - Chloroquine (CQ) resistance in Plasmodium falciparum has been particularly associated with mutations in the pfcrt gene. The present study was carried out in the malaria hyperendemic town of Brazzaville (Republic of Congo, Central Africa) where CQ is still recommended and used as a first-line drug for P. falciparum malaria. We assessed the efficacy of CQ in vivo, and the association between pfcrt mutation at codon 76 and treatment outcome in 50 children with uncomplicated malaria. The failure rate on day 28 was 95.7% and the pfcrt K76T mutation was present in 100% of isolates. No variation in the multiplicity of infection was observed in pre- and post-treatment isolates. In further 87 isolates from uncomplicated patients not treated with CQ, the mutation was detected in 98.5% of isolates. This study confirms the high level of in vivo resistance to CQ and shows the high prevalence of pfcrt K76T mutation in the Republic of Congo. SN - 0001-706X UR - https://www.unboundmedicine.com/medline/citation/16002038/In_vivo_chloroquine_resistance_and_prevalence_of_the_pfcrt_codon_76_mutation_in_Plasmodium_falciparum_isolates_from_the_Republic_of_Congo_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-706X(05)00146-4 DB - PRIME DP - Unbound Medicine ER -