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Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow.
Int J Cardiol. 2006 Apr 04; 108(2):224-30.IJ

Abstract

BACKGROUND

Inflammation has been reported to be a major contributing factor to many cardiovascular events. In the present study, we aimed to evaluate plasma soluble adhesion molecules; intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin as possible indicators of endothelial activation or inflammation in patients with slow coronary flow.

METHOD

Study population included 17 patients with angiographically proven normal coronary arteries and slow coronary flow in all three coronary vessels (group I, 11 male, 6 female, mean age=48+/-9 years), and 20 subjects with angiographically proven normal coronary arteries without associated slow coronary flow (group II, 11 male, 9 female, mean age=50+/-8 years). Coronary flow rates of all patients and control subjects were documented by Thrombolysis In Myocardial Infarction frame count (TIMI frame count). All patients in group I had TIMI frame counts greater than two standard deviation above those of control subjects (group II) and, therefore, were accepted as exhibiting slow coronary flow. Serum levels of ICAM-1, VCAM-1, and E-selectin were measured in all patients and control subjects using commercially available ELISA kits.

RESULTS

Serum ICAM-1, VCAM-1, and E-selectin levels of patients with slow coronary flow were found to be significantly higher than those of control subjects with normal coronary flow (ICAM-1: 545+/-198 ng/ml vs. 242+/-113 ng/ml respectively, p<0.001, VCAM-1: 2040+/-634 ng/ml vs. 918+/-336 ng/ml respectively, p<0.001, E-selectin: 67+/-9 ng/ml vs. 52+/-8 ng/ml respectively, p<0.001). Average TIMI frame count was detected to be significantly correlated with plasma soluble ICAM-1 (r=0.550, p<0.001), VCAM-1 (r=0.569, p<0.001) and E-selectin (r=0.443, p=0.006).

CONCLUSION

Increased levels of soluble adhesion molecules in patients with slow coronary flow may be an indicator of endothelial activation and inflammation and are likely to be in the causal pathway leading to slow coronary flow.

Authors+Show Affiliations

Inonu University Medical Faculty, Department of Cardiology, Malatya, Turkey. drhturhan@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16002164

Citation

Turhan, Hasan, et al. "Increased Plasma Soluble Adhesion Molecules; ICAM-1, VCAM-1, and E-selectin Levels in Patients With Slow Coronary Flow." International Journal of Cardiology, vol. 108, no. 2, 2006, pp. 224-30.
Turhan H, Saydam GS, Erbay AR, et al. Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow. Int J Cardiol. 2006;108(2):224-30.
Turhan, H., Saydam, G. S., Erbay, A. R., Ayaz, S., Yasar, A. S., Aksoy, Y., Basar, N., & Yetkin, E. (2006). Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow. International Journal of Cardiology, 108(2), 224-30.
Turhan H, et al. Increased Plasma Soluble Adhesion Molecules; ICAM-1, VCAM-1, and E-selectin Levels in Patients With Slow Coronary Flow. Int J Cardiol. 2006 Apr 4;108(2):224-30. PubMed PMID: 16002164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow. AU - Turhan,Hasan, AU - Saydam,Gul Sevim, AU - Erbay,Ali Riza, AU - Ayaz,Selime, AU - Yasar,Ayse Saatci, AU - Aksoy,Yuksel, AU - Basar,Nurcan, AU - Yetkin,Ertan, Y1 - 2005/07/05/ PY - 2004/09/25/received PY - 2005/04/04/revised PY - 2005/05/14/accepted PY - 2005/7/9/pubmed PY - 2006/8/4/medline PY - 2005/7/9/entrez SP - 224 EP - 30 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 108 IS - 2 N2 - BACKGROUND: Inflammation has been reported to be a major contributing factor to many cardiovascular events. In the present study, we aimed to evaluate plasma soluble adhesion molecules; intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin as possible indicators of endothelial activation or inflammation in patients with slow coronary flow. METHOD: Study population included 17 patients with angiographically proven normal coronary arteries and slow coronary flow in all three coronary vessels (group I, 11 male, 6 female, mean age=48+/-9 years), and 20 subjects with angiographically proven normal coronary arteries without associated slow coronary flow (group II, 11 male, 9 female, mean age=50+/-8 years). Coronary flow rates of all patients and control subjects were documented by Thrombolysis In Myocardial Infarction frame count (TIMI frame count). All patients in group I had TIMI frame counts greater than two standard deviation above those of control subjects (group II) and, therefore, were accepted as exhibiting slow coronary flow. Serum levels of ICAM-1, VCAM-1, and E-selectin were measured in all patients and control subjects using commercially available ELISA kits. RESULTS: Serum ICAM-1, VCAM-1, and E-selectin levels of patients with slow coronary flow were found to be significantly higher than those of control subjects with normal coronary flow (ICAM-1: 545+/-198 ng/ml vs. 242+/-113 ng/ml respectively, p<0.001, VCAM-1: 2040+/-634 ng/ml vs. 918+/-336 ng/ml respectively, p<0.001, E-selectin: 67+/-9 ng/ml vs. 52+/-8 ng/ml respectively, p<0.001). Average TIMI frame count was detected to be significantly correlated with plasma soluble ICAM-1 (r=0.550, p<0.001), VCAM-1 (r=0.569, p<0.001) and E-selectin (r=0.443, p=0.006). CONCLUSION: Increased levels of soluble adhesion molecules in patients with slow coronary flow may be an indicator of endothelial activation and inflammation and are likely to be in the causal pathway leading to slow coronary flow. SN - 0167-5273 UR - https://www.unboundmedicine.com/medline/citation/16002164/Increased_plasma_soluble_adhesion_molecules L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(05)00730-8 DB - PRIME DP - Unbound Medicine ER -