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Anxiolytic-like effects of ginseng in the elevated plus-maze model: comparison of red ginseng and sun ginseng.
Prog Neuropsychopharmacol Biol Psychiatry. 2005 Jul; 29(6):895-900.PN

Abstract

This study was performed to investigate the anxiolytic-like effects of red ginseng (RG, steamed raw ginseng at 98-100 degrees C) and sun ginseng (SG, heat-processed ginseng at higher temperature) in mice using the elevated plus-maze model. Furthermore, the anxiolytic-like effects of RG and SG were compared to a known active anxiolytic drug (diazepam). The RG butanol fraction (100 mg/kg) significantly increased the number of open arms entries and the time spent on the open arm (indicators of anxiolytic-like effects) compared with that of the saline group. However, lower doses of the SG total extract (50 mg/kg) and the SG butanol fraction (25 and 50 mg/kg) significantly increased the number of open arms entries and the time spent on the open arms. The RG total extract (100 mg/kg) and the SG total extract at a lower dose (25 mg/kg) did not increase the number of open arm entries or the time spent on the open arm. On the other hand, the RG butanol fraction (100 mg/kg), the SG total extract (50 mg/kg), and the SG butanol fraction (50 mg/kg) decreased locomotor activity in a manner similar to diazepam. These data indicate that ginseng has anxiolytic-like effects, and the anxiolytic potential of SG is stronger than that of RG in the elevated plus-maze model. Ginseng saponins have been suggested to play an important role in the anxiolytic effects of ginseng. We provide evidence that ginseng may be useful for the treatment of anxiety.

Authors+Show Affiliations

College of Pharmacy, Seoul National University, Seoul, 151-742, S. Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16002200

Citation

Park, Jeong-Hill, et al. "Anxiolytic-like Effects of Ginseng in the Elevated Plus-maze Model: Comparison of Red Ginseng and Sun Ginseng." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 29, no. 6, 2005, pp. 895-900.
Park JH, Cha HY, Seo JJ, et al. Anxiolytic-like effects of ginseng in the elevated plus-maze model: comparison of red ginseng and sun ginseng. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(6):895-900.
Park, J. H., Cha, H. Y., Seo, J. J., Hong, J. T., Han, K., & Oh, K. W. (2005). Anxiolytic-like effects of ginseng in the elevated plus-maze model: comparison of red ginseng and sun ginseng. Progress in Neuro-psychopharmacology & Biological Psychiatry, 29(6), 895-900.
Park JH, et al. Anxiolytic-like Effects of Ginseng in the Elevated Plus-maze Model: Comparison of Red Ginseng and Sun Ginseng. Prog Neuropsychopharmacol Biol Psychiatry. 2005;29(6):895-900. PubMed PMID: 16002200.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anxiolytic-like effects of ginseng in the elevated plus-maze model: comparison of red ginseng and sun ginseng. AU - Park,Jeong-Hill, AU - Cha,Hwa-Young, AU - Seo,Jeong-Ju, AU - Hong,Jin-Tae, AU - Han,Kun, AU - Oh,Ki-Wan, PY - 2005/04/06/accepted PY - 2005/7/9/pubmed PY - 2005/10/28/medline PY - 2005/7/9/entrez SP - 895 EP - 900 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog Neuropsychopharmacol Biol Psychiatry VL - 29 IS - 6 N2 - This study was performed to investigate the anxiolytic-like effects of red ginseng (RG, steamed raw ginseng at 98-100 degrees C) and sun ginseng (SG, heat-processed ginseng at higher temperature) in mice using the elevated plus-maze model. Furthermore, the anxiolytic-like effects of RG and SG were compared to a known active anxiolytic drug (diazepam). The RG butanol fraction (100 mg/kg) significantly increased the number of open arms entries and the time spent on the open arm (indicators of anxiolytic-like effects) compared with that of the saline group. However, lower doses of the SG total extract (50 mg/kg) and the SG butanol fraction (25 and 50 mg/kg) significantly increased the number of open arms entries and the time spent on the open arms. The RG total extract (100 mg/kg) and the SG total extract at a lower dose (25 mg/kg) did not increase the number of open arm entries or the time spent on the open arm. On the other hand, the RG butanol fraction (100 mg/kg), the SG total extract (50 mg/kg), and the SG butanol fraction (50 mg/kg) decreased locomotor activity in a manner similar to diazepam. These data indicate that ginseng has anxiolytic-like effects, and the anxiolytic potential of SG is stronger than that of RG in the elevated plus-maze model. Ginseng saponins have been suggested to play an important role in the anxiolytic effects of ginseng. We provide evidence that ginseng may be useful for the treatment of anxiety. SN - 0278-5846 UR - https://www.unboundmedicine.com/medline/citation/16002200/Anxiolytic_like_effects_of_ginseng_in_the_elevated_plus_maze_model:_comparison_of_red_ginseng_and_sun_ginseng_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(05)00135-1 DB - PRIME DP - Unbound Medicine ER -