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Alterations in peripheral blood levels of TIMP-1, MMP-2, and MMP-9 in patients with type-2 diabetes.
Diabetes Res Clin Pract. 2005 Aug; 69(2):175-9.DR

Abstract

BACKGROUND AND AIM

In vivo and in vitro experimental findings indicate that the hyperglycemic diabetic milieu can induce altered expression of the matrix metalloproteinase (MMP) genes and contribute to imbalances in vascular matrix homeostasis. We examined the plasma levels of enzymes and inhibitors involved in extracellular matrix turnover.

METHODS

We measured the plasma concentrations of MMP-2, MMP-9, and tissue inhibitor of metalloproteinase 1 (TIMP-1) in 80 type-2 diabetic subjects without uremia and in 80 age-matched controls. In addition, we determined the plasma levels of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and high sensitive(hs) C-reactive protein (CRP) in both groups.

RESULTS

Plasma MMP-2, TIMP-1, and hs-CRP concentrations were significantly elevated in diabetic patients as compared to the control subjects (p<0.05). Plasma levels of MMP-2, MMP-9, TIMP-1, VCAM-1, ICAM-1, and hs-CRP were found not to be significantly associated with age, duration of diabetes, blood pressure, or serum lipid concentrations.

CONCLUSIONS

Plasma MMP-2, TIMP-1 and hs-CRP concentrations were significantly increased in type-2 diabetic patients.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Ajou University School of Medicine, San-5 Wonchon Dong, Yongtong Gu,443-721, Suwon, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16005367

Citation

Lee, Seung Won, et al. "Alterations in Peripheral Blood Levels of TIMP-1, MMP-2, and MMP-9 in Patients With Type-2 Diabetes." Diabetes Research and Clinical Practice, vol. 69, no. 2, 2005, pp. 175-9.
Lee SW, Song KE, Shin DS, et al. Alterations in peripheral blood levels of TIMP-1, MMP-2, and MMP-9 in patients with type-2 diabetes. Diabetes Res Clin Pract. 2005;69(2):175-9.
Lee, S. W., Song, K. E., Shin, D. S., Ahn, S. M., Ha, E. S., Kim, D. J., Nam, M. S., & Lee, K. W. (2005). Alterations in peripheral blood levels of TIMP-1, MMP-2, and MMP-9 in patients with type-2 diabetes. Diabetes Research and Clinical Practice, 69(2), 175-9.
Lee SW, et al. Alterations in Peripheral Blood Levels of TIMP-1, MMP-2, and MMP-9 in Patients With Type-2 Diabetes. Diabetes Res Clin Pract. 2005;69(2):175-9. PubMed PMID: 16005367.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alterations in peripheral blood levels of TIMP-1, MMP-2, and MMP-9 in patients with type-2 diabetes. AU - Lee,Seung Won, AU - Song,Kyoung Eun, AU - Shin,Dong Sun, AU - Ahn,Sung Min, AU - Ha,Eun Suk, AU - Kim,Dae Jung, AU - Nam,Moon Suk, AU - Lee,Kwan-Woo, PY - 2004/08/31/received PY - 2004/12/09/revised PY - 2004/12/10/accepted PY - 2005/7/12/pubmed PY - 2005/10/28/medline PY - 2005/7/12/entrez SP - 175 EP - 9 JF - Diabetes research and clinical practice JO - Diabetes Res Clin Pract VL - 69 IS - 2 N2 - BACKGROUND AND AIM: In vivo and in vitro experimental findings indicate that the hyperglycemic diabetic milieu can induce altered expression of the matrix metalloproteinase (MMP) genes and contribute to imbalances in vascular matrix homeostasis. We examined the plasma levels of enzymes and inhibitors involved in extracellular matrix turnover. METHODS: We measured the plasma concentrations of MMP-2, MMP-9, and tissue inhibitor of metalloproteinase 1 (TIMP-1) in 80 type-2 diabetic subjects without uremia and in 80 age-matched controls. In addition, we determined the plasma levels of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and high sensitive(hs) C-reactive protein (CRP) in both groups. RESULTS: Plasma MMP-2, TIMP-1, and hs-CRP concentrations were significantly elevated in diabetic patients as compared to the control subjects (p<0.05). Plasma levels of MMP-2, MMP-9, TIMP-1, VCAM-1, ICAM-1, and hs-CRP were found not to be significantly associated with age, duration of diabetes, blood pressure, or serum lipid concentrations. CONCLUSIONS: Plasma MMP-2, TIMP-1 and hs-CRP concentrations were significantly increased in type-2 diabetic patients. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/16005367/Alterations_in_peripheral_blood_levels_of_TIMP_1_MMP_2_and_MMP_9_in_patients_with_type_2_diabetes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(05)00012-4 DB - PRIME DP - Unbound Medicine ER -