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Voltammetric behavior and assay of the antibiotic drug cefazolin sodium in bulk form and pharmaceutical formulation at a mercury electrode.
J Pharm Biomed Anal. 2005 Oct 04; 39(5):1051-6.JP

Abstract

The electrochemical behavior of the antibiotic drug cefazolin sodium (CFZ) in Britton-Robinson buffers (pH 2-11) at the mercury electrode was studied by means of dc-polarography, cyclic voltammetry, controlled-potential coulometry and square-wave adsorptive stripping voltammetry techniques. A validated square-wave adsorptive cathodic stripping voltammetric procedure was described for the trace determination of cefazolin in bulk form up to limits of detection and quantitation of 2.6 x 10(-10)M and 8.6 x 10(-10)M, respectively. The method was successfully applied for determination of cefazolin in pharmaceutical preparation without the necessity for samples pretreatment or any time-consuming extraction or evaporation steps prior to the analysis.

Authors+Show Affiliations

Chemistry Department, Faculty of Science, Tanta University, 31527-Tanta, Egypt. hseldesoky@hotmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16005594

Citation

El-Desoky, H S., et al. "Voltammetric Behavior and Assay of the Antibiotic Drug Cefazolin Sodium in Bulk Form and Pharmaceutical Formulation at a Mercury Electrode." Journal of Pharmaceutical and Biomedical Analysis, vol. 39, no. 5, 2005, pp. 1051-6.
El-Desoky HS, Ghoneim EM, Ghoneim MM. Voltammetric behavior and assay of the antibiotic drug cefazolin sodium in bulk form and pharmaceutical formulation at a mercury electrode. J Pharm Biomed Anal. 2005;39(5):1051-6.
El-Desoky, H. S., Ghoneim, E. M., & Ghoneim, M. M. (2005). Voltammetric behavior and assay of the antibiotic drug cefazolin sodium in bulk form and pharmaceutical formulation at a mercury electrode. Journal of Pharmaceutical and Biomedical Analysis, 39(5), 1051-6.
El-Desoky HS, Ghoneim EM, Ghoneim MM. Voltammetric Behavior and Assay of the Antibiotic Drug Cefazolin Sodium in Bulk Form and Pharmaceutical Formulation at a Mercury Electrode. J Pharm Biomed Anal. 2005 Oct 4;39(5):1051-6. PubMed PMID: 16005594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Voltammetric behavior and assay of the antibiotic drug cefazolin sodium in bulk form and pharmaceutical formulation at a mercury electrode. AU - El-Desoky,H S, AU - Ghoneim,E M, AU - Ghoneim,M M, Y1 - 2005/07/07/ PY - 2005/01/18/received PY - 2005/05/20/revised PY - 2005/05/20/accepted PY - 2005/7/12/pubmed PY - 2006/2/9/medline PY - 2005/7/12/entrez SP - 1051 EP - 6 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 39 IS - 5 N2 - The electrochemical behavior of the antibiotic drug cefazolin sodium (CFZ) in Britton-Robinson buffers (pH 2-11) at the mercury electrode was studied by means of dc-polarography, cyclic voltammetry, controlled-potential coulometry and square-wave adsorptive stripping voltammetry techniques. A validated square-wave adsorptive cathodic stripping voltammetric procedure was described for the trace determination of cefazolin in bulk form up to limits of detection and quantitation of 2.6 x 10(-10)M and 8.6 x 10(-10)M, respectively. The method was successfully applied for determination of cefazolin in pharmaceutical preparation without the necessity for samples pretreatment or any time-consuming extraction or evaporation steps prior to the analysis. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/16005594/Voltammetric_behavior_and_assay_of_the_antibiotic_drug_cefazolin_sodium_in_bulk_form_and_pharmaceutical_formulation_at_a_mercury_electrode_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0731-7085(05)00367-5 DB - PRIME DP - Unbound Medicine ER -