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Dentinal defects in Hyp mice not caused by hypophosphatemia alone.
Arch Oral Biol 2006; 51(1):58-63AO

Abstract

The Hyp mouse is a murine homolog of human X-linked hypophosphatemic rickets and displays hypo-mineralization in bone and dentin due to a defect of the phosphate-regulating gene with homology to endopeptidase on the X chromosome (Phex) gene. It has long been considered that the bone and dentin defects in Hyp mice are caused by hypophosphatemia alone, however, several recent studies have indicated the possibility that intrinsic defects are present in Hyp mice osteoblasts. Further, we previously found a hyper-expression of osteocalcin (OC) mRNA in Hyp mouse odontoblasts and suggested the possibility of the presence of intrinsic defects. In the present study, we evaluated morphological features and OC mRNA expression levels in tooth germs of Nor mice with a normal phex gene and a low concentration of serum phosphate, and compared them to those in Hyp and wild-type mice. Nor mice exhibited low serum phosphate levels, however, did not show the characteristic features of dentin defects seen in Hyp mice, such as widened predentin and hyper-expression of OC mRNA. These results suggest that the hypo-mineralization of dentin in Hyp mice is not dependent on serum phosphate level, but rather is affected by intrinsic defects in odontoblasts.

Authors+Show Affiliations

Department of Pediatric Dentistry, Osaka University Graduate School of Dentistry, Suita, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16005844

Citation

Ogawa, T, et al. "Dentinal Defects in Hyp Mice Not Caused By Hypophosphatemia Alone." Archives of Oral Biology, vol. 51, no. 1, 2006, pp. 58-63.
Ogawa T, Onishi T, Hayashibara T, et al. Dentinal defects in Hyp mice not caused by hypophosphatemia alone. Arch Oral Biol. 2006;51(1):58-63.
Ogawa, T., Onishi, T., Hayashibara, T., Sakashita, S., Okawa, R., & Ooshima, T. (2006). Dentinal defects in Hyp mice not caused by hypophosphatemia alone. Archives of Oral Biology, 51(1), pp. 58-63.
Ogawa T, et al. Dentinal Defects in Hyp Mice Not Caused By Hypophosphatemia Alone. Arch Oral Biol. 2006;51(1):58-63. PubMed PMID: 16005844.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dentinal defects in Hyp mice not caused by hypophosphatemia alone. AU - Ogawa,T, AU - Onishi,T, AU - Hayashibara,T, AU - Sakashita,S, AU - Okawa,R, AU - Ooshima,T, Y1 - 2005/07/11/ PY - 2005/03/10/received PY - 2005/05/23/accepted PY - 2005/7/12/pubmed PY - 2006/6/9/medline PY - 2005/7/12/entrez SP - 58 EP - 63 JF - Archives of oral biology JO - Arch. Oral Biol. VL - 51 IS - 1 N2 - The Hyp mouse is a murine homolog of human X-linked hypophosphatemic rickets and displays hypo-mineralization in bone and dentin due to a defect of the phosphate-regulating gene with homology to endopeptidase on the X chromosome (Phex) gene. It has long been considered that the bone and dentin defects in Hyp mice are caused by hypophosphatemia alone, however, several recent studies have indicated the possibility that intrinsic defects are present in Hyp mice osteoblasts. Further, we previously found a hyper-expression of osteocalcin (OC) mRNA in Hyp mouse odontoblasts and suggested the possibility of the presence of intrinsic defects. In the present study, we evaluated morphological features and OC mRNA expression levels in tooth germs of Nor mice with a normal phex gene and a low concentration of serum phosphate, and compared them to those in Hyp and wild-type mice. Nor mice exhibited low serum phosphate levels, however, did not show the characteristic features of dentin defects seen in Hyp mice, such as widened predentin and hyper-expression of OC mRNA. These results suggest that the hypo-mineralization of dentin in Hyp mice is not dependent on serum phosphate level, but rather is affected by intrinsic defects in odontoblasts. SN - 0003-9969 UR - https://www.unboundmedicine.com/medline/citation/16005844/Dentinal_defects_in_Hyp_mice_not_caused_by_hypophosphatemia_alone L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9969(05)00141-X DB - PRIME DP - Unbound Medicine ER -