Tags

Type your tag names separated by a space and hit enter

Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha).
J Pharmacol Sci. 2005 Jul; 98(3):200-4.JP

Abstract

Sir2 (silent information regulator 2) is an NAD-dependent deacetylase that is broadly conserved from bacteria to humans. It catalyzes a unique deacetylation reaction using NAD, and specific inhibitors and activators of its activity have been discovered. In yeast, Sir2 deacetylates histones and participates in transcription silencing and the suppression of recombination. Sir2 is also implicated in the regulation of aging, because its increased expression extends the lifespan of yeast and nematodes. Mammalian SIRT1 (Sir2alpha) is a member of the Sir2 family. Recently, SIRT1 was shown to interact with various transcription factors such as p53, forkhead transcription factor (FOXO) family proteins, and MyoD, and to participate in stress tolerance, differentiation, and development.

Authors+Show Affiliations

Department of Pharmacology, Sapporo Medical University, School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

16006743

Citation

Hisahara, Shin, et al. "Transcriptional Regulation of Neuronal Genes and Its Effect On Neural Functions: NAD-dependent Histone Deacetylase SIRT1 (Sir2alpha)." Journal of Pharmacological Sciences, vol. 98, no. 3, 2005, pp. 200-4.
Hisahara S, Chiba S, Matsumoto H, et al. Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha). J Pharmacol Sci. 2005;98(3):200-4.
Hisahara, S., Chiba, S., Matsumoto, H., & Horio, Y. (2005). Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha). Journal of Pharmacological Sciences, 98(3), 200-4.
Hisahara S, et al. Transcriptional Regulation of Neuronal Genes and Its Effect On Neural Functions: NAD-dependent Histone Deacetylase SIRT1 (Sir2alpha). J Pharmacol Sci. 2005;98(3):200-4. PubMed PMID: 16006743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transcriptional regulation of neuronal genes and its effect on neural functions: NAD-dependent histone deacetylase SIRT1 (Sir2alpha). AU - Hisahara,Shin, AU - Chiba,Susumu, AU - Matsumoto,Hiroyuki, AU - Horio,Yoshiyuki, Y1 - 2005/07/09/ PY - 2005/7/12/pubmed PY - 2005/9/30/medline PY - 2005/7/12/entrez SP - 200 EP - 4 JF - Journal of pharmacological sciences JO - J. Pharmacol. Sci. VL - 98 IS - 3 N2 - Sir2 (silent information regulator 2) is an NAD-dependent deacetylase that is broadly conserved from bacteria to humans. It catalyzes a unique deacetylation reaction using NAD, and specific inhibitors and activators of its activity have been discovered. In yeast, Sir2 deacetylates histones and participates in transcription silencing and the suppression of recombination. Sir2 is also implicated in the regulation of aging, because its increased expression extends the lifespan of yeast and nematodes. Mammalian SIRT1 (Sir2alpha) is a member of the Sir2 family. Recently, SIRT1 was shown to interact with various transcription factors such as p53, forkhead transcription factor (FOXO) family proteins, and MyoD, and to participate in stress tolerance, differentiation, and development. SN - 1347-8613 UR - https://www.unboundmedicine.com/medline/citation/16006743/Transcriptional_regulation_of_neuronal_genes_and_its_effect_on_neural_functions:_NAD_dependent_histone_deacetylase_SIRT1__Sir2alpha__ L2 - https://linkinghub.elsevier.com/retrieve/pii/JST.JSTAGE/jphs/FMJ05001X2 DB - PRIME DP - Unbound Medicine ER -