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Effect of cranberry juice consumption on urinary stone risk factors.
J Urol. 2005 Aug; 174(2):590-4; quiz 801.JU

Abstract

PURPOSE

We evaluated the effect of cranberry juice on urinary stone risk factors.

MATERIALS AND METHODS

A total of 12 normal subjects and 12 calcium oxalate stone formers underwent 2, 7-day phases of study in random order while on a controlled metabolic diet. Subjects ingested 1 l of cranberry juice (CBJ) daily in 1 phase and 1 l of deionized water in the other phase. On the last 2 days of each phase 2, 24-hour urine collections and blood samples were obtained for stone risk factors and serum chemistries.

RESULTS

No significant differences were found between normal subjects and stone formers in response to CBJ and, therefore, the groups were combined. CBJ significantly increased urinary calcium (from 154 to 177 mg per day, p =0.0008) and urinary oxalate (from 26.4 to 29.2 mg per day, p =0.04), thereby increasing urinary saturation of calcium oxalate by 18%. Urinary citrate was unchanged and urinary magnesium increased slightly. Urinary pH decreased (from 5.97 to 5.67, p =0.0005), and urinary ammonium, titratable acidity and net acid excretion increased during CBJ ingestion. Urinary uric acid decreased (from 544 to 442 mg per day, p <0.0001) as did serum uric acid. Thus, the urinary saturation of brushite and monosodium urate was reduced by CBJ but the amount of undissociated uric acid increased.

CONCLUSIONS

CBJ exerts a mixed effect on urinary stone forming propensity. It reduces urinary pH likely by providing an acid load and decreases urinary uric acid perhaps by retarding urate synthesis. Overall CBJ increases the risk of calcium oxalate and uric acid stone formation but decreases the risk of brushite stones.

Authors+Show Affiliations

Department of Urology, Mayo Clinic, Rochester, Minnesota, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16006907

Citation

Gettman, Matthew T., et al. "Effect of Cranberry Juice Consumption On Urinary Stone Risk Factors." The Journal of Urology, vol. 174, no. 2, 2005, pp. 590-4; quiz 801.
Gettman MT, Ogan K, Brinkley LJ, et al. Effect of cranberry juice consumption on urinary stone risk factors. J Urol. 2005;174(2):590-4; quiz 801.
Gettman, M. T., Ogan, K., Brinkley, L. J., Adams-Huet, B., Pak, C. Y., & Pearle, M. S. (2005). Effect of cranberry juice consumption on urinary stone risk factors. The Journal of Urology, 174(2), 590-4; quiz 801.
Gettman MT, et al. Effect of Cranberry Juice Consumption On Urinary Stone Risk Factors. J Urol. 2005;174(2):590-4; quiz 801. PubMed PMID: 16006907.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of cranberry juice consumption on urinary stone risk factors. AU - Gettman,Matthew T, AU - Ogan,Kenneth, AU - Brinkley,Linda J, AU - Adams-Huet,Beverley, AU - Pak,Charles Y C, AU - Pearle,Margaret S, PY - 2005/7/12/pubmed PY - 2005/9/17/medline PY - 2005/7/12/entrez SP - 590-4; quiz 801 JF - The Journal of urology JO - J. Urol. VL - 174 IS - 2 N2 - PURPOSE: We evaluated the effect of cranberry juice on urinary stone risk factors. MATERIALS AND METHODS: A total of 12 normal subjects and 12 calcium oxalate stone formers underwent 2, 7-day phases of study in random order while on a controlled metabolic diet. Subjects ingested 1 l of cranberry juice (CBJ) daily in 1 phase and 1 l of deionized water in the other phase. On the last 2 days of each phase 2, 24-hour urine collections and blood samples were obtained for stone risk factors and serum chemistries. RESULTS: No significant differences were found between normal subjects and stone formers in response to CBJ and, therefore, the groups were combined. CBJ significantly increased urinary calcium (from 154 to 177 mg per day, p =0.0008) and urinary oxalate (from 26.4 to 29.2 mg per day, p =0.04), thereby increasing urinary saturation of calcium oxalate by 18%. Urinary citrate was unchanged and urinary magnesium increased slightly. Urinary pH decreased (from 5.97 to 5.67, p =0.0005), and urinary ammonium, titratable acidity and net acid excretion increased during CBJ ingestion. Urinary uric acid decreased (from 544 to 442 mg per day, p <0.0001) as did serum uric acid. Thus, the urinary saturation of brushite and monosodium urate was reduced by CBJ but the amount of undissociated uric acid increased. CONCLUSIONS: CBJ exerts a mixed effect on urinary stone forming propensity. It reduces urinary pH likely by providing an acid load and decreases urinary uric acid perhaps by retarding urate synthesis. Overall CBJ increases the risk of calcium oxalate and uric acid stone formation but decreases the risk of brushite stones. SN - 0022-5347 UR - https://www.unboundmedicine.com/medline/citation/16006907/Effect_of_cranberry_juice_consumption_on_urinary_stone_risk_factors_ L2 - https://www.jurology.com/doi/full/10.1097/01.ju.0000165168.68054.f8?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -