Tags

Type your tag names separated by a space and hit enter

Pesticides exposure and genetic polymorphism of paraoxonase in the susceptibility of Parkinson's disease.
Acta Neurol Taiwan 2005; 14(2):55-60AN

Abstract

PURPOSE

The manifestation of Parkinson's disease (PD) is characterized by bradykinesia, resting tremor, and rigidity. The etiology of PD remains unknown. Recently several studies suggest that some environmental and genetic factors may be related to the cause of PD. Genetic variation in xenobiotic metabolizing enzymes involved in the disposition of pesticides, such as paraoxonase I (PON 1), may increase the risk of PD. We investigated the association between PON1 polymorphism, pesticides exposure and risk of Parkinson's disease in Taiwanese population.

METHODS

We enrolled 162 controls and 125 patients with idiopathic PD. Histories of exposures to environmental factors and other information were collected with a questionnaire filled out during a face-to-face interview with the subject. The data included years of farming, drinking water sources, occupational exposures to pesticides, duration and the initial age of the pesticides exposure. Buccal mucosa cells are collected from each subject and PON1 polymorphism at codon 54 (L and M alleles) is studied with PCR-based restriction fragment length polymorphism (RFLP) analysis.

RESULTS

There is significant association between the risk of PD and exposure to pesticides (OR=1.72, 95% CI=1.07-2.75). On the otherhand, no significant differences are found in PON1 genotype or allelic distribution between PD and control groups. We further investigated participants who had reported exposure to pesticides and found that the frequency distribution of PON1 genotypes did not differ significantly between patients and controls.

CONCLUSION

The present survey reveals the close relationship between exposure to pesticides and Parkinson's disease. There are no significant differences in the distribution of PON1 genotypes between cases and controls.

Authors+Show Affiliations

Department of Neurology, Buddhist Dalin Tzu Chi General Hospital, No. 2, Min Sheng Road, Dalin, Chia Yi, Taiwan. csfong@tcts.seed.net.twNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16008163

Citation

Fong, Chin-Shih, et al. "Pesticides Exposure and Genetic Polymorphism of Paraoxonase in the Susceptibility of Parkinson's Disease." Acta Neurologica Taiwanica, vol. 14, no. 2, 2005, pp. 55-60.
Fong CS, Cheng CW, Wu RM. Pesticides exposure and genetic polymorphism of paraoxonase in the susceptibility of Parkinson's disease. Acta Neurol Taiwan. 2005;14(2):55-60.
Fong, C. S., Cheng, C. W., & Wu, R. M. (2005). Pesticides exposure and genetic polymorphism of paraoxonase in the susceptibility of Parkinson's disease. Acta Neurologica Taiwanica, 14(2), pp. 55-60.
Fong CS, Cheng CW, Wu RM. Pesticides Exposure and Genetic Polymorphism of Paraoxonase in the Susceptibility of Parkinson's Disease. Acta Neurol Taiwan. 2005;14(2):55-60. PubMed PMID: 16008163.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pesticides exposure and genetic polymorphism of paraoxonase in the susceptibility of Parkinson's disease. AU - Fong,Chin-Shih, AU - Cheng,Chun-Wen, AU - Wu,Ruey-Meei, PY - 2005/7/13/pubmed PY - 2005/8/10/medline PY - 2005/7/13/entrez SP - 55 EP - 60 JF - Acta neurologica Taiwanica JO - Acta Neurol Taiwan VL - 14 IS - 2 N2 - PURPOSE: The manifestation of Parkinson's disease (PD) is characterized by bradykinesia, resting tremor, and rigidity. The etiology of PD remains unknown. Recently several studies suggest that some environmental and genetic factors may be related to the cause of PD. Genetic variation in xenobiotic metabolizing enzymes involved in the disposition of pesticides, such as paraoxonase I (PON 1), may increase the risk of PD. We investigated the association between PON1 polymorphism, pesticides exposure and risk of Parkinson's disease in Taiwanese population. METHODS: We enrolled 162 controls and 125 patients with idiopathic PD. Histories of exposures to environmental factors and other information were collected with a questionnaire filled out during a face-to-face interview with the subject. The data included years of farming, drinking water sources, occupational exposures to pesticides, duration and the initial age of the pesticides exposure. Buccal mucosa cells are collected from each subject and PON1 polymorphism at codon 54 (L and M alleles) is studied with PCR-based restriction fragment length polymorphism (RFLP) analysis. RESULTS: There is significant association between the risk of PD and exposure to pesticides (OR=1.72, 95% CI=1.07-2.75). On the otherhand, no significant differences are found in PON1 genotype or allelic distribution between PD and control groups. We further investigated participants who had reported exposure to pesticides and found that the frequency distribution of PON1 genotypes did not differ significantly between patients and controls. CONCLUSION: The present survey reveals the close relationship between exposure to pesticides and Parkinson's disease. There are no significant differences in the distribution of PON1 genotypes between cases and controls. SN - 1028-768X UR - https://www.unboundmedicine.com/medline/citation/16008163/Pesticides_exposure_and_genetic_polymorphism_of_paraoxonase_in_the_susceptibility_of_Parkinson's_disease_ L2 - https://medlineplus.gov/occupationalhealth.html DB - PRIME DP - Unbound Medicine ER -