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Relationship between aeroallergen and food allergen sensitization in childhood.
Clin Exp Allergy. 2005 Jul; 35(7):933-40.CE

Abstract

BACKGROUND

Previous studies measuring the prevalence of allergen sensitization have been relatively small and used small numbers of allergens. To effectively evaluate children with atopic disease, we need an accurate knowledge of which allergens are important.

OBJECTIVE

To measure the prevalence of sensitization within a large unselected birth cohort, to examine the associations between sensitization to different allergens and determine whether atopy can be defined by a small panel of allergens.

METHODS

The Avon Longitudinal Study of Parents and Children is a population-based birth cohort of 13,638 singletons surviving to 4 weeks of age. The cohort was skin tested at 7 years of age to house dust mite (Dermatophagoides pteronyssinus), grass pollens, cat, peanuts, mixed tree nuts and egg and one of three other panels: animal danders, foods or aeroallergens. Sensitization was defined as a weal diameter of > or =3 mm. The strength of associations between sensitization to different allergens was tested by calculating the odds ratio adjusted for sensitization to D. pteronyssinus and grass pollen and gender.

RESULTS

Valid data were obtained from 6412 singletons. Sensitization was most common to aeroallergens: grass pollens (8.5%), D. pteronyssinus (7.8%), cat (4.9%), D. farinae (3.6%), dog (2.7%), horse (1.4%), rabbit (1.4%). Of the foods tested, the most common sensitization was to peanut (1.4%) and mixed tree nuts (1.0%). More than 95% of subjects with sensitization to any of the 29 allergens tested were sensitized to one of grass, D. pteronyssinus or cat allergen. There were strong associations of multiple sensitizations both within and between different allergen classes (pollens, animals, foods, peanut and tree nuts).

CONCLUSIONS

Seven-year-old children in the UK are primarily sensitized to aeroallergens, but also to peanuts and tree nuts. There are strong associations between sensitization within allergen groups as well as between allergen groups. Further studies are required to observe whether similar associations are seen with clinical allergy to these allergens.

Authors+Show Affiliations

Paediatric Allergy, Asthma and Immunology, Imperial College at St Mary's, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16008681

Citation

Roberts, G, et al. "Relationship Between Aeroallergen and Food Allergen Sensitization in Childhood." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, vol. 35, no. 7, 2005, pp. 933-40.
Roberts G, Peckitt C, Northstone K, et al. Relationship between aeroallergen and food allergen sensitization in childhood. Clin Exp Allergy. 2005;35(7):933-40.
Roberts, G., Peckitt, C., Northstone, K., Strachan, D., Lack, G., Henderson, J., & Golding, J. (2005). Relationship between aeroallergen and food allergen sensitization in childhood. Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology, 35(7), 933-40.
Roberts G, et al. Relationship Between Aeroallergen and Food Allergen Sensitization in Childhood. Clin Exp Allergy. 2005;35(7):933-40. PubMed PMID: 16008681.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between aeroallergen and food allergen sensitization in childhood. AU - Roberts,G, AU - Peckitt,C, AU - Northstone,K, AU - Strachan,D, AU - Lack,G, AU - Henderson,J, AU - Golding,J, AU - ,, PY - 2005/7/13/pubmed PY - 2006/1/31/medline PY - 2005/7/13/entrez SP - 933 EP - 40 JF - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JO - Clin. Exp. Allergy VL - 35 IS - 7 N2 - BACKGROUND: Previous studies measuring the prevalence of allergen sensitization have been relatively small and used small numbers of allergens. To effectively evaluate children with atopic disease, we need an accurate knowledge of which allergens are important. OBJECTIVE: To measure the prevalence of sensitization within a large unselected birth cohort, to examine the associations between sensitization to different allergens and determine whether atopy can be defined by a small panel of allergens. METHODS: The Avon Longitudinal Study of Parents and Children is a population-based birth cohort of 13,638 singletons surviving to 4 weeks of age. The cohort was skin tested at 7 years of age to house dust mite (Dermatophagoides pteronyssinus), grass pollens, cat, peanuts, mixed tree nuts and egg and one of three other panels: animal danders, foods or aeroallergens. Sensitization was defined as a weal diameter of > or =3 mm. The strength of associations between sensitization to different allergens was tested by calculating the odds ratio adjusted for sensitization to D. pteronyssinus and grass pollen and gender. RESULTS: Valid data were obtained from 6412 singletons. Sensitization was most common to aeroallergens: grass pollens (8.5%), D. pteronyssinus (7.8%), cat (4.9%), D. farinae (3.6%), dog (2.7%), horse (1.4%), rabbit (1.4%). Of the foods tested, the most common sensitization was to peanut (1.4%) and mixed tree nuts (1.0%). More than 95% of subjects with sensitization to any of the 29 allergens tested were sensitized to one of grass, D. pteronyssinus or cat allergen. There were strong associations of multiple sensitizations both within and between different allergen classes (pollens, animals, foods, peanut and tree nuts). CONCLUSIONS: Seven-year-old children in the UK are primarily sensitized to aeroallergens, but also to peanuts and tree nuts. There are strong associations between sensitization within allergen groups as well as between allergen groups. Further studies are required to observe whether similar associations are seen with clinical allergy to these allergens. SN - 0954-7894 UR - https://www.unboundmedicine.com/medline/citation/16008681/Relationship_between_aeroallergen_and_food_allergen_sensitization_in_childhood_ L2 - https://doi.org/10.1111/j.1365-2222.2005.02280.x DB - PRIME DP - Unbound Medicine ER -