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[Determination of interleukin-17 concentrations in peritoneal fluid of women with endometriosis].
Zhonghua Fu Chan Ke Za Zhi 2005; 40(6):380-2ZF

Abstract

OBJECTIVE

To investigate the role of interleukin-17 (IL-17) in the pathogenesis of endometriosis.

METHODS

Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentrations of IL-17 in peritoneal fluid of 36 patients with different stage endometriosis and 26 patients without endometriosis.

RESULTS

The concentrations of IL-17 in peritoneal fluid of the patients with and without endometriosis were (5.7 +/- 1.9) ng/L and (5.3 +/- 1.4) ng/L, respectively, without significant difference between the two groups (P > 0.05). According to staging criteria of r-AFS, the concentrations of peritoneal IL-17 in the patients with stage I-II endometriosis (6.4 +/- 1.7) ng/L were significantly higher than those in the patients with stage III-IV endometriosis (5.1 +/- 1.8) ng/L and in the patients without endometriosis (P < 0.05). There was no difference with regard to peritoneal IL-17 concentrations between proliferative and secretory phases in the patients with or without endometriosis (P > 0.05). The levels of peritoneal IL-17 were significantly higher in the endometriosis patients with infertility (6.4 +/- 1.8) ng/L than in the endometriosis patients without infertility (5.1 +/- 1.8) ng/L (P < 0.05).

CONCLUSION

IL-17 may play an important role in the pathogenesis of early endometriosis and pathophysiology of endometriosis-associated infertility.

Authors+Show Affiliations

Department of Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

16008887

Citation

Zhang, Xin-mei, et al. "[Determination of Interleukin-17 Concentrations in Peritoneal Fluid of Women With Endometriosis]." Zhonghua Fu Chan Ke Za Zhi, vol. 40, no. 6, 2005, pp. 380-2.
Zhang XM, Lin J, Xu H, et al. [Determination of interleukin-17 concentrations in peritoneal fluid of women with endometriosis]. Zhonghua Fu Chan Ke Za Zhi. 2005;40(6):380-2.
Zhang, X. M., Lin, J., Xu, H., Deng, L., & Qian, Y. L. (2005). [Determination of interleukin-17 concentrations in peritoneal fluid of women with endometriosis]. Zhonghua Fu Chan Ke Za Zhi, 40(6), pp. 380-2.
Zhang XM, et al. [Determination of Interleukin-17 Concentrations in Peritoneal Fluid of Women With Endometriosis]. Zhonghua Fu Chan Ke Za Zhi. 2005;40(6):380-2. PubMed PMID: 16008887.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Determination of interleukin-17 concentrations in peritoneal fluid of women with endometriosis]. AU - Zhang,Xin-mei, AU - Lin,Jun, AU - Xu,Hong, AU - Deng,Lin, AU - Qian,Yu-li, PY - 2005/7/13/pubmed PY - 2010/6/4/medline PY - 2005/7/13/entrez SP - 380 EP - 2 JF - Zhonghua fu chan ke za zhi JO - Zhonghua Fu Chan Ke Za Zhi VL - 40 IS - 6 N2 - OBJECTIVE: To investigate the role of interleukin-17 (IL-17) in the pathogenesis of endometriosis. METHODS: Enzyme-linked immunosorbent assay (ELISA) was used to detect the concentrations of IL-17 in peritoneal fluid of 36 patients with different stage endometriosis and 26 patients without endometriosis. RESULTS: The concentrations of IL-17 in peritoneal fluid of the patients with and without endometriosis were (5.7 +/- 1.9) ng/L and (5.3 +/- 1.4) ng/L, respectively, without significant difference between the two groups (P > 0.05). According to staging criteria of r-AFS, the concentrations of peritoneal IL-17 in the patients with stage I-II endometriosis (6.4 +/- 1.7) ng/L were significantly higher than those in the patients with stage III-IV endometriosis (5.1 +/- 1.8) ng/L and in the patients without endometriosis (P < 0.05). There was no difference with regard to peritoneal IL-17 concentrations between proliferative and secretory phases in the patients with or without endometriosis (P > 0.05). The levels of peritoneal IL-17 were significantly higher in the endometriosis patients with infertility (6.4 +/- 1.8) ng/L than in the endometriosis patients without infertility (5.1 +/- 1.8) ng/L (P < 0.05). CONCLUSION: IL-17 may play an important role in the pathogenesis of early endometriosis and pathophysiology of endometriosis-associated infertility. SN - 0529-567X UR - https://www.unboundmedicine.com/medline/citation/16008887/[Determination_of_interleukin_17_concentrations_in_peritoneal_fluid_of_women_with_endometriosis]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0529-567X&amp;year=2005&amp;vol=40&amp;issue=6&amp;fpage=380 DB - PRIME DP - Unbound Medicine ER -