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[Increased levels of advanced oxidation protein products are associated with atherosclerosis in chronic kidney disease].

Abstract

OBJECTIVE

Accumulation of advanced oxidation protein products (AOPP) has been found in patients with chronic kidney disease (CKD). The study was performed to investigate the association between serum levels of AOPP and atherosclerosis in CKD.

METHODS

109 CKD patients were involved in this cross-sectional cohort study. Carotid artery intima-medial thickness (IMT), cross-sectional calculated intima-media area (cIM area) and plaques were determined with non-invasive high-resolution B-mode ultrasonography. Serum levels of AOPP, malonyldialdehyde (MDA), glutathione peroxidase (GSHPx) and C-reactive protein (CRP) were also determined.

RESULTS

Higher serum AOPP levels were found in patients with CKD [(64.72 +/- 19.69) micromol/L] as compared with those in healthy controls [(30.16 +/- 6.46) micromol/L, P < 0.01]. AOPP levels in dialysis patients [(70.02 +/- 16.51) micromol/L] were significantly higher than those in pre-dialysis patients [(51.71 +/- 15.53) micromol/L, P < 0.01]. AOPP levels increased with the progression of renal dysfunction and inversely correlated with creatinine clearance (Ccr) (r = -0.292, P < 0.05). Patients with carotid artery plaques showed significantly higher levels of AOPP [(73.87 +/- 19.40) micromol/L] as compared with patients without carotid artery plaques [(58.41 +/- 16.09) micromol/L, P < 0.01]. Serum levels of AOPP were strongly associated with carotid artery IMT (r = 0.332, P < 0.01) and cIM area (r = 0.288, P < 0.05). By stepwise multiple regression analysis and adjusting for age, gender, blood pressure, smoking, diabetes, body mass index (BMI), hemoglobin, lipid and albumin, strong association was still present between AOPP levels and carotid artery IMT (beta = 0.313, P < 0.001) and cIMarea (beta = 0.301, P < 0.01). Serum levels of AOPP were correlated positively with serum MDA (r = 0.300, P = 0.01) and CRP levels (r = 0.255, P < 0.05), while negatively with serum GSHPx (r = -0.647, P < 0.01).

CONCLUSIONS

Serum levels of AOPP increased with the progression of renal failure and closely associated with occurrence of atherosclerosis. Strong association between serum AOPP and CRP suggests that AOPP might be involved in the pathogenesis of micro-inflammation which has been considered as a contributing factor for atherosclerosis in CKD.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Nephrology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.

    , , , , ,

    Source

    Zhonghua nei ke za zhi 44:5 2005 May pg 342-6

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Atherosclerosis
    Biomarkers
    Blood Proteins
    Carotid Arteries
    Cohort Studies
    Cross-Sectional Studies
    Female
    Humans
    Kidney Failure, Chronic
    Male
    Middle Aged
    Oxidative Stress
    Renal Dialysis
    Ultrasonography

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    chi

    PubMed ID

    16009002

    Citation

    Yang, Xiao-bing, et al. "[Increased Levels of Advanced Oxidation Protein Products Are Associated With Atherosclerosis in Chronic Kidney Disease]." Zhonghua Nei Ke Za Zhi, vol. 44, no. 5, 2005, pp. 342-6.
    Yang XB, Hou FF, Wu Q, et al. [Increased levels of advanced oxidation protein products are associated with atherosclerosis in chronic kidney disease]. Zhonghua Nei Ke Za Zhi. 2005;44(5):342-6.
    Yang, X. B., Hou, F. F., Wu, Q., Zhou, H., Liu, Z. R., Yang, Y., & Zhang, X. (2005). [Increased levels of advanced oxidation protein products are associated with atherosclerosis in chronic kidney disease]. Zhonghua Nei Ke Za Zhi, 44(5), pp. 342-6.
    Yang XB, et al. [Increased Levels of Advanced Oxidation Protein Products Are Associated With Atherosclerosis in Chronic Kidney Disease]. Zhonghua Nei Ke Za Zhi. 2005;44(5):342-6. PubMed PMID: 16009002.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - [Increased levels of advanced oxidation protein products are associated with atherosclerosis in chronic kidney disease]. AU - Yang,Xiao-bing, AU - Hou,Fan-fan, AU - Wu,Qiang, AU - Zhou,Hua, AU - Liu,Zheng-rong, AU - Yang,Yan, AU - Zhang,Xun, PY - 2005/7/13/pubmed PY - 2006/7/11/medline PY - 2005/7/13/entrez SP - 342 EP - 6 JF - Zhonghua nei ke za zhi JO - Zhonghua Nei Ke Za Zhi VL - 44 IS - 5 N2 - OBJECTIVE: Accumulation of advanced oxidation protein products (AOPP) has been found in patients with chronic kidney disease (CKD). The study was performed to investigate the association between serum levels of AOPP and atherosclerosis in CKD. METHODS: 109 CKD patients were involved in this cross-sectional cohort study. Carotid artery intima-medial thickness (IMT), cross-sectional calculated intima-media area (cIM area) and plaques were determined with non-invasive high-resolution B-mode ultrasonography. Serum levels of AOPP, malonyldialdehyde (MDA), glutathione peroxidase (GSHPx) and C-reactive protein (CRP) were also determined. RESULTS: Higher serum AOPP levels were found in patients with CKD [(64.72 +/- 19.69) micromol/L] as compared with those in healthy controls [(30.16 +/- 6.46) micromol/L, P < 0.01]. AOPP levels in dialysis patients [(70.02 +/- 16.51) micromol/L] were significantly higher than those in pre-dialysis patients [(51.71 +/- 15.53) micromol/L, P < 0.01]. AOPP levels increased with the progression of renal dysfunction and inversely correlated with creatinine clearance (Ccr) (r = -0.292, P < 0.05). Patients with carotid artery plaques showed significantly higher levels of AOPP [(73.87 +/- 19.40) micromol/L] as compared with patients without carotid artery plaques [(58.41 +/- 16.09) micromol/L, P < 0.01]. Serum levels of AOPP were strongly associated with carotid artery IMT (r = 0.332, P < 0.01) and cIM area (r = 0.288, P < 0.05). By stepwise multiple regression analysis and adjusting for age, gender, blood pressure, smoking, diabetes, body mass index (BMI), hemoglobin, lipid and albumin, strong association was still present between AOPP levels and carotid artery IMT (beta = 0.313, P < 0.001) and cIMarea (beta = 0.301, P < 0.01). Serum levels of AOPP were correlated positively with serum MDA (r = 0.300, P = 0.01) and CRP levels (r = 0.255, P < 0.05), while negatively with serum GSHPx (r = -0.647, P < 0.01). CONCLUSIONS: Serum levels of AOPP increased with the progression of renal failure and closely associated with occurrence of atherosclerosis. Strong association between serum AOPP and CRP suggests that AOPP might be involved in the pathogenesis of micro-inflammation which has been considered as a contributing factor for atherosclerosis in CKD. SN - 0578-1426 UR - https://www.unboundmedicine.com/medline/citation/16009002/[Increased_levels_of_advanced_oxidation_protein_products_are_associated_with_atherosclerosis_in_chronic_kidney_disease]_ L2 - http://journal.yiigle.com/LinkIn.do?linkin_type=pubmed&amp;issn=0578-1426&amp;year=2005&amp;vol=44&amp;issue=5&amp;fpage=342 DB - PRIME DP - Unbound Medicine ER -