Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst.Chem Commun (Camb). 2005 Jul 28CC
Abstract
The linear amino acid-catalyzed direct asymmetric intermolecular aldol reaction is presented; simple amino acids such as alanine, valine, isoleucine, aspartate, alanine tetrazole and serine catalyzed the direct catalytic asymmetric intermolecular aldol reactions between unmodified ketones and aldehydes with excellent stereocontrol and furnished the corresponding aldol products in up to 98% yield and with up to > 99% ee.
Pub Type(s)
Journal Article
Research Support, Non-U.S. Gov't
Language
eng
PubMed ID
16010332
Citation
Córdova, Armando, et al. "Acyclic Amino Acid-catalyzed Direct Asymmetric Aldol Reactions: Alanine, the Simplest Stereoselective Organocatalyst." Chemical Communications (Cambridge, England), 2005, pp. 3586-8.
Córdova A, Zou W, Ibrahem I, et al. Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst. Chem Commun (Camb). 2005.
Córdova, A., Zou, W., Ibrahem, I., Reyes, E., Engqvist, M., & Liao, W. W. (2005). Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst. Chemical Communications (Cambridge, England), (28), 3586-8.
Córdova A, et al. Acyclic Amino Acid-catalyzed Direct Asymmetric Aldol Reactions: Alanine, the Simplest Stereoselective Organocatalyst. Chem Commun (Camb). 2005 Jul 28;(28)3586-8. PubMed PMID: 16010332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR
T1 - Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst.
AU - Córdova,Armando,
AU - Zou,Weibiao,
AU - Ibrahem,Ismail,
AU - Reyes,Efraim,
AU - Engqvist,Magnus,
AU - Liao,Wei-Wei,
Y1 - 2005/06/21/
PY - 2005/7/13/pubmed
PY - 2007/3/6/medline
PY - 2005/7/13/entrez
SP - 3586
EP - 8
JF - Chemical communications (Cambridge, England)
JO - Chem Commun (Camb)
IS - 28
N2 - The linear amino acid-catalyzed direct asymmetric intermolecular aldol reaction is presented; simple amino acids such as alanine, valine, isoleucine, aspartate, alanine tetrazole and serine catalyzed the direct catalytic asymmetric intermolecular aldol reactions between unmodified ketones and aldehydes with excellent stereocontrol and furnished the corresponding aldol products in up to 98% yield and with up to > 99% ee.
SN - 1359-7345
UR - https://www.unboundmedicine.com/medline/citation/16010332/Acyclic_amino_acid_catalyzed_direct_asymmetric_aldol_reactions:_alanine_the_simplest_stereoselective_organocatalyst_
DB - PRIME
DP - Unbound Medicine
ER -
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