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Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst.
Chem Commun (Camb). 2005 Jul 28CC

Abstract

The linear amino acid-catalyzed direct asymmetric intermolecular aldol reaction is presented; simple amino acids such as alanine, valine, isoleucine, aspartate, alanine tetrazole and serine catalyzed the direct catalytic asymmetric intermolecular aldol reactions between unmodified ketones and aldehydes with excellent stereocontrol and furnished the corresponding aldol products in up to 98% yield and with up to > 99% ee.

Authors+Show Affiliations

Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, Sweden. acordova1a@netscape.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16010332

Citation

Córdova, Armando, et al. "Acyclic Amino Acid-catalyzed Direct Asymmetric Aldol Reactions: Alanine, the Simplest Stereoselective Organocatalyst." Chemical Communications (Cambridge, England), 2005, pp. 3586-8.
Córdova A, Zou W, Ibrahem I, et al. Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst. Chem Commun (Camb). 2005.
Córdova, A., Zou, W., Ibrahem, I., Reyes, E., Engqvist, M., & Liao, W. W. (2005). Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst. Chemical Communications (Cambridge, England), (28), 3586-8.
Córdova A, et al. Acyclic Amino Acid-catalyzed Direct Asymmetric Aldol Reactions: Alanine, the Simplest Stereoselective Organocatalyst. Chem Commun (Camb). 2005 Jul 28;(28)3586-8. PubMed PMID: 16010332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acyclic amino acid-catalyzed direct asymmetric aldol reactions: alanine, the simplest stereoselective organocatalyst. AU - Córdova,Armando, AU - Zou,Weibiao, AU - Ibrahem,Ismail, AU - Reyes,Efraim, AU - Engqvist,Magnus, AU - Liao,Wei-Wei, Y1 - 2005/06/21/ PY - 2005/7/13/pubmed PY - 2007/3/6/medline PY - 2005/7/13/entrez SP - 3586 EP - 8 JF - Chemical communications (Cambridge, England) JO - Chem Commun (Camb) IS - 28 N2 - The linear amino acid-catalyzed direct asymmetric intermolecular aldol reaction is presented; simple amino acids such as alanine, valine, isoleucine, aspartate, alanine tetrazole and serine catalyzed the direct catalytic asymmetric intermolecular aldol reactions between unmodified ketones and aldehydes with excellent stereocontrol and furnished the corresponding aldol products in up to 98% yield and with up to > 99% ee. SN - 1359-7345 UR - https://www.unboundmedicine.com/medline/citation/16010332/Acyclic_amino_acid_catalyzed_direct_asymmetric_aldol_reactions:_alanine_the_simplest_stereoselective_organocatalyst_ DB - PRIME DP - Unbound Medicine ER -
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