Tags

Type your tag names separated by a space and hit enter

Reactivity of peroxynitrite and nitric oxide with LDL.
IUBMB Life. 2005 Jun; 57(6):407-12.IL

Abstract

Low density lipoprotein (LDL) oxidation by peroxynitrite is a complex process, finely modulated by control of peroxynitrite formation, LDL availability and free-radical scavenging by nitric oxide (*NO), ascorbate and alpha-tocopherol (alpha -TOH). In the presence of CO2, lipid targets are spared at the expense of surface constituents. Since surface damage may lead to oxidation-induced LDL aggregation and particle recognition by scavenger receptors, CO2 cannot be considered an inhibitor of peroxynitrite-dependent LDL modifications. Chromanols, urate and ascorbate cannot scavenge peroxynitrite in the vasculature, although intermediates of urate oxidation and high ascorbate concentrations may do soin vitro. Most if not all of the protection against peroxynitrite-induced LDL oxidation afforded by urate, ascorbate, chromanols and also*NO should be considered to depend on their free radical scavenging abilities, including inactivation of lipid peroxyl radicals (LOO),*NO2, and CO3*-; as well as their capacity to reduce high oxidation states of metal centers. Peroxynitrite direct interception by reduced manganese (II) porphyrins is possibly the most powerful although unspecific strategy to inhibit peroxynitrite reactions. In light of the recent demonstration of nitrated bioactive lipids in vivo, renewed interest in the mechanisms of peroxynitrite- and nitric oxide-mediated lipid nitration and nitrosation is guaranteed.

Authors+Show Affiliations

Departamento de Bioquímica and Center for Free Radical and Biomedical Research, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

16012049

Citation

Botti, Horacio, et al. "Reactivity of Peroxynitrite and Nitric Oxide With LDL." IUBMB Life, vol. 57, no. 6, 2005, pp. 407-12.
Botti H, Trostchansky A, Batthyány C, et al. Reactivity of peroxynitrite and nitric oxide with LDL. IUBMB Life. 2005;57(6):407-12.
Botti, H., Trostchansky, A., Batthyány, C., & Rubbo, H. (2005). Reactivity of peroxynitrite and nitric oxide with LDL. IUBMB Life, 57(6), 407-12.
Botti H, et al. Reactivity of Peroxynitrite and Nitric Oxide With LDL. IUBMB Life. 2005;57(6):407-12. PubMed PMID: 16012049.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reactivity of peroxynitrite and nitric oxide with LDL. AU - Botti,Horacio, AU - Trostchansky,Andrés, AU - Batthyány,Carlos, AU - Rubbo,Homero, PY - 2005/7/14/pubmed PY - 2005/10/4/medline PY - 2005/7/14/entrez SP - 407 EP - 12 JF - IUBMB life JO - IUBMB Life VL - 57 IS - 6 N2 - Low density lipoprotein (LDL) oxidation by peroxynitrite is a complex process, finely modulated by control of peroxynitrite formation, LDL availability and free-radical scavenging by nitric oxide (*NO), ascorbate and alpha-tocopherol (alpha -TOH). In the presence of CO2, lipid targets are spared at the expense of surface constituents. Since surface damage may lead to oxidation-induced LDL aggregation and particle recognition by scavenger receptors, CO2 cannot be considered an inhibitor of peroxynitrite-dependent LDL modifications. Chromanols, urate and ascorbate cannot scavenge peroxynitrite in the vasculature, although intermediates of urate oxidation and high ascorbate concentrations may do soin vitro. Most if not all of the protection against peroxynitrite-induced LDL oxidation afforded by urate, ascorbate, chromanols and also*NO should be considered to depend on their free radical scavenging abilities, including inactivation of lipid peroxyl radicals (LOO),*NO2, and CO3*-; as well as their capacity to reduce high oxidation states of metal centers. Peroxynitrite direct interception by reduced manganese (II) porphyrins is possibly the most powerful although unspecific strategy to inhibit peroxynitrite reactions. In light of the recent demonstration of nitrated bioactive lipids in vivo, renewed interest in the mechanisms of peroxynitrite- and nitric oxide-mediated lipid nitration and nitrosation is guaranteed. SN - 1521-6543 UR - https://www.unboundmedicine.com/medline/citation/16012049/Reactivity_of_peroxynitrite_and_nitric_oxide_with_LDL_ L2 - https://doi.org/10.1080/15216540500137701 DB - PRIME DP - Unbound Medicine ER -