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Levels of brain natriuretic peptide in children with right ventricular overload due to congenital cardiac disease.
Cardiol Young. 2005 Aug; 15(4):396-401.CY

Abstract

OBJECTIVE

To evaluate the role of the concentration of brain natriuretic peptide in the plasma, and its correlation with haemodynamic right ventricular parameters, in children with overload of the right ventricle due to congenital cardiac disease.

METHODS

We studied 31 children, with a mean age of 4.8 years, with volume or pressure overload of the right ventricle caused by congenital cardiac disease. Of the patients, 19 had undergone surgical biventricular correction of tetralogy of Fallot, 11 with pulmonary stenosis and 8 with pulmonary atresia, and 12 patients were studied prior to operations, 7 with atrial septal defects and 5 with anomalous pulmonary venous connections. We measured brain natriuretic peptide using Triage(R), from Biosite, United States of America. We determined end-diastolic pressures of the right ventricle, and the peak ratio of right to left ventricular pressures, by cardiac catheterization and correlated them with concentrations of brain natriuretic peptide in the plasma.

RESULTS

The mean concentrations of brain natriuretic peptide were 87.7, with a range from 5 to 316, picograms per millilitre. Mean end-diastolic pressure in the right ventricle was 5.6, with a range from 2 to 10, millimetres of mercury, and the mean ratio of right to left ventricular pressure was 0.56, with a range from 0.24 to 1.03. There was a positive correlation between the concentrations of brain natriuretic peptide and the ratio of right to left ventricular pressure (r equal to 0.7844, p less than 0.0001) in all patients. These positive correlations remained when the children with tetralogy of Fallot, and those with atrial septal defects or anomalous pulmonary venous connection, were analysed as separate groups. We also found a weak correlation was shown between end-diastolic right ventricular pressure and concentrations of brain natriuretic peptide in the plasma (r equal to 0.5947, p equal to 0.0004).

CONCLUSION

There is a significant correlation between right ventricular haemodynamic parameters and concentrations of brain natriuretic peptide in the plasma of children with right ventricular overload due to different types of congenital cardiac disease. The monitoring of brain natriuretic peptide may provide a non-invasive and safe quantitative follow up of the right ventricular pressure and volume overload in these patients.

Authors+Show Affiliations

Herzzentrum, Klinik und Poliklinik für Kinderkardiologie, Hamburg, Germany. mir@uke.uni-hamburg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16014188

Citation

Mir, Thomas S., et al. "Levels of Brain Natriuretic Peptide in Children With Right Ventricular Overload Due to Congenital Cardiac Disease." Cardiology in the Young, vol. 15, no. 4, 2005, pp. 396-401.
Mir TS, Falkenberg J, Friedrich B, et al. Levels of brain natriuretic peptide in children with right ventricular overload due to congenital cardiac disease. Cardiol Young. 2005;15(4):396-401.
Mir, T. S., Falkenberg, J., Friedrich, B., Gottschalk, U., Lê, T. P., Laer, S., & Weil, J. (2005). Levels of brain natriuretic peptide in children with right ventricular overload due to congenital cardiac disease. Cardiology in the Young, 15(4), 396-401.
Mir TS, et al. Levels of Brain Natriuretic Peptide in Children With Right Ventricular Overload Due to Congenital Cardiac Disease. Cardiol Young. 2005;15(4):396-401. PubMed PMID: 16014188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levels of brain natriuretic peptide in children with right ventricular overload due to congenital cardiac disease. AU - Mir,Thomas S, AU - Falkenberg,Jan, AU - Friedrich,Bernd, AU - Gottschalk,Urda, AU - Lê,Throng Phi, AU - Laer,Stephanie, AU - Weil,Jochen, PY - 2005/7/15/pubmed PY - 2005/12/13/medline PY - 2005/7/15/entrez SP - 396 EP - 401 JF - Cardiology in the young JO - Cardiol Young VL - 15 IS - 4 N2 - OBJECTIVE: To evaluate the role of the concentration of brain natriuretic peptide in the plasma, and its correlation with haemodynamic right ventricular parameters, in children with overload of the right ventricle due to congenital cardiac disease. METHODS: We studied 31 children, with a mean age of 4.8 years, with volume or pressure overload of the right ventricle caused by congenital cardiac disease. Of the patients, 19 had undergone surgical biventricular correction of tetralogy of Fallot, 11 with pulmonary stenosis and 8 with pulmonary atresia, and 12 patients were studied prior to operations, 7 with atrial septal defects and 5 with anomalous pulmonary venous connections. We measured brain natriuretic peptide using Triage(R), from Biosite, United States of America. We determined end-diastolic pressures of the right ventricle, and the peak ratio of right to left ventricular pressures, by cardiac catheterization and correlated them with concentrations of brain natriuretic peptide in the plasma. RESULTS: The mean concentrations of brain natriuretic peptide were 87.7, with a range from 5 to 316, picograms per millilitre. Mean end-diastolic pressure in the right ventricle was 5.6, with a range from 2 to 10, millimetres of mercury, and the mean ratio of right to left ventricular pressure was 0.56, with a range from 0.24 to 1.03. There was a positive correlation between the concentrations of brain natriuretic peptide and the ratio of right to left ventricular pressure (r equal to 0.7844, p less than 0.0001) in all patients. These positive correlations remained when the children with tetralogy of Fallot, and those with atrial septal defects or anomalous pulmonary venous connection, were analysed as separate groups. We also found a weak correlation was shown between end-diastolic right ventricular pressure and concentrations of brain natriuretic peptide in the plasma (r equal to 0.5947, p equal to 0.0004). CONCLUSION: There is a significant correlation between right ventricular haemodynamic parameters and concentrations of brain natriuretic peptide in the plasma of children with right ventricular overload due to different types of congenital cardiac disease. The monitoring of brain natriuretic peptide may provide a non-invasive and safe quantitative follow up of the right ventricular pressure and volume overload in these patients. SN - 1047-9511 UR - https://www.unboundmedicine.com/medline/citation/16014188/Levels_of_brain_natriuretic_peptide_in_children_with_right_ventricular_overload_due_to_congenital_cardiac_disease_ L2 - https://www.cambridge.org/core/product/identifier/S1047951105000831/type/journal_article DB - PRIME DP - Unbound Medicine ER -