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Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats.
Am J Physiol Regul Integr Comp Physiol. 2005 Aug; 289(2):R486-R494.AJ

Abstract

Insulin resistance and adiposity induced by a long-term sucrose-rich diet (SRD) in rats could be reversed by fish oil (FO). Regulation of plasma leptin and adiponectin levels, as well as their gene expression, by FO might be implicated in these findings. This study was designed to evaluate the long-term regulation of leptin and adiponectin by dietary FO in a dietary model of insulin resistance induced by long-term SRD in rats and to determine their impact on adiposity and insulin sensitivity. Rats were randomized to consume a control diet (CD; n = 25) or an SRD (n = 50) for 7 mo. Subsequently, the SRD-fed rats were randomized to consume SRD+FO or to continue on SRD for an additional 2 mo. Long-term SRD induced overweight and decreased both plasma leptin and adiponectin levels without change in gene expression. Dyslipidemia, adiposity, and insulin resistance accompanied these modifications. Shifting the source of fat to FO for 2 mo increased plasma levels of both adipokines, reversed insulin resistance and dyslipidemia, and improved adiposity. These results were not associated with modifications in gene expression. These results suggest that increasing both adipokines by dietary FO might play an essential role in the normalization of insulin resistance and adiposity in dietary-induced, insulin-resistant models.

Authors+Show Affiliations

Dept. of Biochemistry, School of Biochemistry, University of Litoral, Ciudad Universitaria, Paraje El Pozo C.C 242, 3000 Santa Fe, Argentina.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16014450

Citation

Rossi, Andrea S., et al. "Dietary Fish Oil Positively Regulates Plasma Leptin and Adiponectin Levels in Sucrose-fed, Insulin-resistant Rats." American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, vol. 289, no. 2, 2005, pp. R486-R494.
Rossi AS, Lombardo YB, Lacorte JM, et al. Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats. Am J Physiol Regul Integr Comp Physiol. 2005;289(2):R486-R494.
Rossi, A. S., Lombardo, Y. B., Lacorte, J. M., Chicco, A. G., Rouault, C., Slama, G., & Rizkalla, S. W. (2005). Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology, 289(2), R486-R494.
Rossi AS, et al. Dietary Fish Oil Positively Regulates Plasma Leptin and Adiponectin Levels in Sucrose-fed, Insulin-resistant Rats. Am J Physiol Regul Integr Comp Physiol. 2005;289(2):R486-R494. PubMed PMID: 16014450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary fish oil positively regulates plasma leptin and adiponectin levels in sucrose-fed, insulin-resistant rats. AU - Rossi,Andrea S, AU - Lombardo,Yolanda B, AU - Lacorte,Jean-Marc, AU - Chicco,Adriana G, AU - Rouault,Christine, AU - Slama,Gérard, AU - Rizkalla,Salwa W, PY - 2005/7/15/pubmed PY - 2005/9/2/medline PY - 2005/7/15/entrez SP - R486 EP - R494 JF - American journal of physiology. Regulatory, integrative and comparative physiology JO - Am. J. Physiol. Regul. Integr. Comp. Physiol. VL - 289 IS - 2 N2 - Insulin resistance and adiposity induced by a long-term sucrose-rich diet (SRD) in rats could be reversed by fish oil (FO). Regulation of plasma leptin and adiponectin levels, as well as their gene expression, by FO might be implicated in these findings. This study was designed to evaluate the long-term regulation of leptin and adiponectin by dietary FO in a dietary model of insulin resistance induced by long-term SRD in rats and to determine their impact on adiposity and insulin sensitivity. Rats were randomized to consume a control diet (CD; n = 25) or an SRD (n = 50) for 7 mo. Subsequently, the SRD-fed rats were randomized to consume SRD+FO or to continue on SRD for an additional 2 mo. Long-term SRD induced overweight and decreased both plasma leptin and adiponectin levels without change in gene expression. Dyslipidemia, adiposity, and insulin resistance accompanied these modifications. Shifting the source of fat to FO for 2 mo increased plasma levels of both adipokines, reversed insulin resistance and dyslipidemia, and improved adiposity. These results were not associated with modifications in gene expression. These results suggest that increasing both adipokines by dietary FO might play an essential role in the normalization of insulin resistance and adiposity in dietary-induced, insulin-resistant models. SN - 0363-6119 UR - https://www.unboundmedicine.com/medline/citation/16014450/Dietary_fish_oil_positively_regulates_plasma_leptin_and_adiponectin_levels_in_sucrose_fed_insulin_resistant_rats_ L2 - http://www.physiology.org/doi/full/10.1152/ajpregu.00846.2004?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -