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Acebutolol-induced subacute cutaneous lupus erythematosus.
Skin Pharmacol Physiol. 2005 Sep-Oct; 18(5):230-3.SP

Abstract

Beta-blocking medications are rarely associated with drug-induced lupus erythematosus syndrome and have never been incriminated as a cause of subacute lupus erythematosus (SCLE). We present herein the first case of SCLE induced by acebutolol. A 57-year-old woman presented with a 1-month history of a cutaneous eruption of the photo-exposed areas. One month ago, the patient had started a treatment with oral acebutolol to cure a hypertension of 1-year evolution. Physical examination revealed erythematous scaly annular plaques, involving the face, arms and trunk. Immunologic serology findings revealed a positive titer of antinuclear antibodies up to 1/1,280 with positivity of antihistone and Ro/SSA antibodies. Acebutolol was stopped, and the lesions cleared completely 4 months later. Literature data, along with our case, suggest a link between acebutolol therapy and the onset of a lupus syndrome. Although this is the first report of acebutolol-induced SCLE, we should be aware of this occurrence, and avoidance of acebutolol is recommended in patients with stigmata of lupus erythematosus.

Authors+Show Affiliations

Fenniche S
Dermatology Department, Habib Thameur Hospital, Tunis, Tunisia. fenniche.samy@planet.tn
Dhaoui A
No affiliation info available
Ammar FB
No affiliation info available
Benmously R
No affiliation info available
Marrak H
No affiliation info available
Mokhtar I
No affiliation info available

MeSH

AcebutololAdrenergic beta-AntagonistsAntibodies, AntinuclearFemaleHumansHypertensionLupus Erythematosus, CutaneousMiddle Aged

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

16015021

Citation

Fenniche, S, et al. "Acebutolol-induced Subacute Cutaneous Lupus Erythematosus." Skin Pharmacology and Physiology, vol. 18, no. 5, 2005, pp. 230-3.
Fenniche S, Dhaoui A, Ammar FB, et al. Acebutolol-induced subacute cutaneous lupus erythematosus. Skin Pharmacol Physiol. 2005;18(5):230-3.
Fenniche, S., Dhaoui, A., Ammar, F. B., Benmously, R., Marrak, H., & Mokhtar, I. (2005). Acebutolol-induced subacute cutaneous lupus erythematosus. Skin Pharmacology and Physiology, 18(5), 230-3.
Fenniche S, et al. Acebutolol-induced Subacute Cutaneous Lupus Erythematosus. Skin Pharmacol Physiol. 2005 Sep-Oct;18(5):230-3. PubMed PMID: 16015021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acebutolol-induced subacute cutaneous lupus erythematosus. AU - Fenniche,S, AU - Dhaoui,A, AU - Ammar,F Ben, AU - Benmously,R, AU - Marrak,H, AU - Mokhtar,I, Y1 - 2005/07/05/ PY - 2004/08/13/received PY - 2005/01/06/accepted PY - 2005/7/15/pubmed PY - 2006/2/4/medline PY - 2005/7/15/entrez SP - 230 EP - 3 JF - Skin pharmacology and physiology JO - Skin Pharmacol Physiol VL - 18 IS - 5 N2 - Beta-blocking medications are rarely associated with drug-induced lupus erythematosus syndrome and have never been incriminated as a cause of subacute lupus erythematosus (SCLE). We present herein the first case of SCLE induced by acebutolol. A 57-year-old woman presented with a 1-month history of a cutaneous eruption of the photo-exposed areas. One month ago, the patient had started a treatment with oral acebutolol to cure a hypertension of 1-year evolution. Physical examination revealed erythematous scaly annular plaques, involving the face, arms and trunk. Immunologic serology findings revealed a positive titer of antinuclear antibodies up to 1/1,280 with positivity of antihistone and Ro/SSA antibodies. Acebutolol was stopped, and the lesions cleared completely 4 months later. Literature data, along with our case, suggest a link between acebutolol therapy and the onset of a lupus syndrome. Although this is the first report of acebutolol-induced SCLE, we should be aware of this occurrence, and avoidance of acebutolol is recommended in patients with stigmata of lupus erythematosus. SN - 1660-5527 UR - https://www.unboundmedicine.com/medline/citation/16015021/Acebutolol_induced_subacute_cutaneous_lupus_erythematosus_ DB - PRIME DP - Unbound Medicine ER -