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Hemorheology, sickle cell trait, and alpha-thalassemia in athletes: effects of exercise.

Abstract

PURPOSE

This study investigated hemorheological parameters in response to exercise in sickle cell trait (SCT) athletes with or without alpha-thalassemia

METHODS

Six athletes with SCT (HbAS), 7 athletes with SCT and alpha-thalassemia (HbASAT), and 10 control athletes (HbAA) performed a progressive and maximal exercise test on cycloergometer. Blood viscosity (etab), plasma viscosity (etap), etab at corrected hematocrit (etab45), hematocrit (Hct), and red blood cell (RBC) rigidity were assessed at rest, at maximal exercise and 24 h after exercise

RESULTS

etab and etap were not different between the three groups at any time. Exercise induced changes in etab in HbAA and HbASAT groups but not in HbAS group. etab45 was higher in HbAS group compared with the other groups (P < 0.05), at rest and 24 h after exercise and increased only in HbAA group in response to exercise. HbAS group had lower Hct than HbAA group at any time. Hct and etap increased after exercise and declined under baseline values 24 h after exercise in all groups. RBC rigidity was higher in HbAS group compared with HbAA and HbASAT groups at any time, and was lower and higher at maximal exercise and 24 h after exercise, respectively, in all groups compared with resting values

CONCLUSIONS

These results demonstrate that HbAS group is prone to higher RBC rigidity, which might lead to hemorheological alterations that are thought to participate to microcirculation disorders. However, these alterations are limited by the coexistence of alpha-thalassemia. Moreover, hemorheological parameters were not further impaired in SCT athletes with or without alpha-thalassemia in response to exercise. Training status might be protective from physiological stresses usually leading to sickling process in SCT carriers.

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  • Authors+Show Affiliations

    ,

    Center of Research and Innovation on Sports, Claude Bernard University of Lyon 1, Villeurbanne, France.

    , , , , , , , ,

    Source

    MeSH

    Adult
    Blood Viscosity
    Case-Control Studies
    Exercise
    France
    Hemorheology
    Humans
    Sickle Cell Trait
    Sports
    alpha-Thalassemia

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    16015123

    Citation

    Monchanin, Géraldine, et al. "Hemorheology, Sickle Cell Trait, and Alpha-thalassemia in Athletes: Effects of Exercise." Medicine and Science in Sports and Exercise, vol. 37, no. 7, 2005, pp. 1086-92.
    Monchanin G, Connes P, Wouassi D, et al. Hemorheology, sickle cell trait, and alpha-thalassemia in athletes: effects of exercise. Med Sci Sports Exerc. 2005;37(7):1086-92.
    Monchanin, G., Connes, P., Wouassi, D., Francina, A., Djoda, B., Banga, P. E., ... Martin, C. (2005). Hemorheology, sickle cell trait, and alpha-thalassemia in athletes: effects of exercise. Medicine and Science in Sports and Exercise, 37(7), pp. 1086-92.
    Monchanin G, et al. Hemorheology, Sickle Cell Trait, and Alpha-thalassemia in Athletes: Effects of Exercise. Med Sci Sports Exerc. 2005;37(7):1086-92. PubMed PMID: 16015123.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Hemorheology, sickle cell trait, and alpha-thalassemia in athletes: effects of exercise. AU - Monchanin,Géraldine, AU - Connes,Philippe, AU - Wouassi,Dieudonné, AU - Francina,Alain, AU - Djoda,Bernard, AU - Banga,Pierre Edmond, AU - Owona,François Xavier, AU - Thiriet,Patrice, AU - Massarelli,Raphaël, AU - Martin,Cyril, PY - 2005/7/15/pubmed PY - 2005/9/16/medline PY - 2005/7/15/entrez SP - 1086 EP - 92 JF - Medicine and science in sports and exercise JO - Med Sci Sports Exerc VL - 37 IS - 7 N2 - PURPOSE: This study investigated hemorheological parameters in response to exercise in sickle cell trait (SCT) athletes with or without alpha-thalassemia METHODS: Six athletes with SCT (HbAS), 7 athletes with SCT and alpha-thalassemia (HbASAT), and 10 control athletes (HbAA) performed a progressive and maximal exercise test on cycloergometer. Blood viscosity (etab), plasma viscosity (etap), etab at corrected hematocrit (etab45), hematocrit (Hct), and red blood cell (RBC) rigidity were assessed at rest, at maximal exercise and 24 h after exercise RESULTS: etab and etap were not different between the three groups at any time. Exercise induced changes in etab in HbAA and HbASAT groups but not in HbAS group. etab45 was higher in HbAS group compared with the other groups (P < 0.05), at rest and 24 h after exercise and increased only in HbAA group in response to exercise. HbAS group had lower Hct than HbAA group at any time. Hct and etap increased after exercise and declined under baseline values 24 h after exercise in all groups. RBC rigidity was higher in HbAS group compared with HbAA and HbASAT groups at any time, and was lower and higher at maximal exercise and 24 h after exercise, respectively, in all groups compared with resting values CONCLUSIONS: These results demonstrate that HbAS group is prone to higher RBC rigidity, which might lead to hemorheological alterations that are thought to participate to microcirculation disorders. However, these alterations are limited by the coexistence of alpha-thalassemia. Moreover, hemorheological parameters were not further impaired in SCT athletes with or without alpha-thalassemia in response to exercise. Training status might be protective from physiological stresses usually leading to sickling process in SCT carriers. SN - 0195-9131 UR - https://www.unboundmedicine.com/medline/citation/16015123/Hemorheology_sickle_cell_trait_and_alpha_thalassemia_in_athletes:_effects_of_exercise_ L2 - http://Insights.ovid.com/pubmed?pmid=16015123 DB - PRIME DP - Unbound Medicine ER -