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A low-protein diet exacerbates postprandial chylomicron concentration in moderately dyslipidaemic subjects in comparison to a lean red meat protein-enriched diet.
Eur J Clin Nutr. 2005 Oct; 59(10):1142-8.EJ

Abstract

OBJECTIVE

To investigate whether altering energy intake as red meat protein or carbohydrate modifies chylomicron homeostasis and postprandial lipaemia.

DESIGN

Randomized single-blind dietary intervention trial.

SETTING

School of Public Health, Division of Health Science, Curtin University, Perth, Western Australia.

SUBJECTS

A total of 20 moderately hypertriglyceridaemic but otherwise healthy subjects were recruited and completed the study.

INTERVENTION

Participants consumed an isocaloric weight maintenance diet low in protein (14, 53 and 30% of energy as protein, carbohydrate and fat, respectively) or high in protein (25, 35 and 30% energy as protein, carbohydrate and fat) for a period of 6 weeks. Fasting plasma lipids and postprandial lipoprotein studies (triglyceride and apolipoprotein B48) following an oral fat challenge were carried out at the start and conclusion of the dietary intervention period.

RESULTS

Consumption of the low- or high-protein diet had no significant effect on fasting plasma or postprandial lipaemia, the latter determined as the incremental area under the triglyceride curve following a fat challenge. However, subjects who consumed a low-protein diet for 6 weeks had a substantially exaggerated postprandial chylomicron response, indicated as the area under the apo B48 curve following a fat challenge. The change in postprandial chylomicron kinetics could not be explained by changes in insulin sensitivity, which appeared to be similar before and after intervention with either diet.

CONCLUSIONS

Daily moderate consumption of a lean red meat protein-enriched diet attenuates postprandial chylomicronaemia in response to ingestion of a fatty meal.

Authors+Show Affiliations

School of Public Health, Australian Technology Network Centre for Metabolic Fitness, Curtin University of Technology, Perth, Australia. j.Mamo@curtin.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16015257

Citation

Mamo, J C L., et al. "A Low-protein Diet Exacerbates Postprandial Chylomicron Concentration in Moderately Dyslipidaemic Subjects in Comparison to a Lean Red Meat Protein-enriched Diet." European Journal of Clinical Nutrition, vol. 59, no. 10, 2005, pp. 1142-8.
Mamo JC, James AP, Soares MJ, et al. A low-protein diet exacerbates postprandial chylomicron concentration in moderately dyslipidaemic subjects in comparison to a lean red meat protein-enriched diet. Eur J Clin Nutr. 2005;59(10):1142-8.
Mamo, J. C., James, A. P., Soares, M. J., Griffiths, D. G., Purcell, K., & Schwenke, J. L. (2005). A low-protein diet exacerbates postprandial chylomicron concentration in moderately dyslipidaemic subjects in comparison to a lean red meat protein-enriched diet. European Journal of Clinical Nutrition, 59(10), 1142-8.
Mamo JC, et al. A Low-protein Diet Exacerbates Postprandial Chylomicron Concentration in Moderately Dyslipidaemic Subjects in Comparison to a Lean Red Meat Protein-enriched Diet. Eur J Clin Nutr. 2005;59(10):1142-8. PubMed PMID: 16015257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A low-protein diet exacerbates postprandial chylomicron concentration in moderately dyslipidaemic subjects in comparison to a lean red meat protein-enriched diet. AU - Mamo,J C L, AU - James,A P, AU - Soares,M J, AU - Griffiths,D G, AU - Purcell,K, AU - Schwenke,J L, PY - 2005/7/15/pubmed PY - 2005/12/31/medline PY - 2005/7/15/entrez SP - 1142 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 IS - 10 N2 - OBJECTIVE: To investigate whether altering energy intake as red meat protein or carbohydrate modifies chylomicron homeostasis and postprandial lipaemia. DESIGN: Randomized single-blind dietary intervention trial. SETTING: School of Public Health, Division of Health Science, Curtin University, Perth, Western Australia. SUBJECTS: A total of 20 moderately hypertriglyceridaemic but otherwise healthy subjects were recruited and completed the study. INTERVENTION: Participants consumed an isocaloric weight maintenance diet low in protein (14, 53 and 30% of energy as protein, carbohydrate and fat, respectively) or high in protein (25, 35 and 30% energy as protein, carbohydrate and fat) for a period of 6 weeks. Fasting plasma lipids and postprandial lipoprotein studies (triglyceride and apolipoprotein B48) following an oral fat challenge were carried out at the start and conclusion of the dietary intervention period. RESULTS: Consumption of the low- or high-protein diet had no significant effect on fasting plasma or postprandial lipaemia, the latter determined as the incremental area under the triglyceride curve following a fat challenge. However, subjects who consumed a low-protein diet for 6 weeks had a substantially exaggerated postprandial chylomicron response, indicated as the area under the apo B48 curve following a fat challenge. The change in postprandial chylomicron kinetics could not be explained by changes in insulin sensitivity, which appeared to be similar before and after intervention with either diet. CONCLUSIONS: Daily moderate consumption of a lean red meat protein-enriched diet attenuates postprandial chylomicronaemia in response to ingestion of a fatty meal. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16015257/A_low_protein_diet_exacerbates_postprandial_chylomicron_concentration_in_moderately_dyslipidaemic_subjects_in_comparison_to_a_lean_red_meat_protein_enriched_diet_ L2 - http://dx.doi.org/10.1038/sj.ejcn.1602224 DB - PRIME DP - Unbound Medicine ER -