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Protective role of vitamin E on the oxidative stress in Hansen's disease (Leprosy) patients.
Eur J Clin Nutr. 2005 Oct; 59(10):1121-8.EJ

Abstract

BACKGROUND

A constellation of reactive oxygen species (ROS) capable of damaging cellular constituents generated in excess during the chronic, inflammatory, neurodegenerative disease process of leprosy. The consequences of this leads to enhanced oxidative stress and lower antioxidant status. Enzymatic antioxidants provide first line defense against ROS. We have measured the levels of oxidative stress indices like lipid peroxidation (LPO), protein carbonyls together with enzymatic antioxidants in the blood samples of control and leprosy patients. Nutritional rehabilitation by way of exogenous supplementation of functionally efficient antioxidants like vitamin E reactivates the enzymatic antioxidant system and guards against the insult caused by ROS during the pathogenesis of the disease and antileprosy chemotherapy.

DESIGN

Untreated leprosy patients were selected on the basis of clinical examination and skin smear. All diagnosed untreated leprosy patients received multi drug therapy (MDT) consisting of rifampicin, dapsone and clofazimine as recommended by World Health Organization. A small number of untreated cases were selected for co-supplementation of vitamin E along with MDT. Oxidative stress indices, enzymatic and nonenzymatic antioxidant status were assayed in untreated, MDT treated and those supplemented vitamin E along with MDT.

STATISTICAL METHODS

We have compared the significance in the mean+/-s.d. values of the oxidative stress indices and the levels of antioxidants using one way analysis of variance (ANOVA) between control, untreated, MDT treated and those supplemented vitamin E with MDT and the results were significant at P < 0.05. Statistical analysis of the results suggests that oral administration of vitamin E lowers oxidative stress and augments antioxidant status in affected individuals.

RESULTS

Enhanced oxidative stress as evidenced by increased LPO and protein carbonyl in leprosy cases lowers the antioxidant status. Treatment with MDT has a limited impact on increased oxidative stress and decreased antioxidant status. Coadministration of vitamin E along with MDT decreases oxidative stress and activate the antioxidant status.

DISCUSSION

The excess production of ROS as seen in leprosy cases could lead to degeneration of tissues and derangement of internal organs. The possible reason for the decreased antioxidant status in leprosy cases may be increased production of ROS, deranged liver function, and the free radical producing ability of drugs used in MDT of leprosy. Intervention with antioxidant supplementation like vitamin E prevents oxidative stress mediated through ROS and activates the net antioxidant status during the chronic course of the disease and antileprosy chemotherapy.

Authors+Show Affiliations

Vijayaraghavan R
Central Leprosy Teaching and Research Institute, Chengalpattu, Tamilnadu, India. vijayaraghavanr@yahoo.com
Suribabu CS
No affiliation info available
Sekar B
No affiliation info available
Oommen PK
No affiliation info available
Kavithalakshmi SN
No affiliation info available
Madhusudhanan N
No affiliation info available
Panneerselvam C
No affiliation info available

MeSH

AdultAnalysis of VarianceAntioxidantsCatalaseDietary SupplementsFemaleGlutathione PeroxidaseGlutathione ReductaseGlutathione TransferaseHumansLeprostatic AgentsLeprosyLipid PeroxidationMaleMiddle AgedOxidative StressReactive Oxygen SpeciesSuperoxide DismutaseTreatment OutcomeVitamin E

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16015260

Citation

Vijayaraghavan, R, et al. "Protective Role of Vitamin E On the Oxidative Stress in Hansen's Disease (Leprosy) Patients." European Journal of Clinical Nutrition, vol. 59, no. 10, 2005, pp. 1121-8.
Vijayaraghavan R, Suribabu CS, Sekar B, et al. Protective role of vitamin E on the oxidative stress in Hansen's disease (Leprosy) patients. Eur J Clin Nutr. 2005;59(10):1121-8.
Vijayaraghavan, R., Suribabu, C. S., Sekar, B., Oommen, P. K., Kavithalakshmi, S. N., Madhusudhanan, N., & Panneerselvam, C. (2005). Protective role of vitamin E on the oxidative stress in Hansen's disease (Leprosy) patients. European Journal of Clinical Nutrition, 59(10), 1121-8.
Vijayaraghavan R, et al. Protective Role of Vitamin E On the Oxidative Stress in Hansen's Disease (Leprosy) Patients. Eur J Clin Nutr. 2005;59(10):1121-8. PubMed PMID: 16015260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective role of vitamin E on the oxidative stress in Hansen's disease (Leprosy) patients. AU - Vijayaraghavan,R, AU - Suribabu,C S, AU - Sekar,B, AU - Oommen,P K, AU - Kavithalakshmi,S N, AU - Madhusudhanan,N, AU - Panneerselvam,C, PY - 2005/7/15/pubmed PY - 2005/12/31/medline PY - 2005/7/15/entrez SP - 1121 EP - 8 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 IS - 10 N2 - BACKGROUND: A constellation of reactive oxygen species (ROS) capable of damaging cellular constituents generated in excess during the chronic, inflammatory, neurodegenerative disease process of leprosy. The consequences of this leads to enhanced oxidative stress and lower antioxidant status. Enzymatic antioxidants provide first line defense against ROS. We have measured the levels of oxidative stress indices like lipid peroxidation (LPO), protein carbonyls together with enzymatic antioxidants in the blood samples of control and leprosy patients. Nutritional rehabilitation by way of exogenous supplementation of functionally efficient antioxidants like vitamin E reactivates the enzymatic antioxidant system and guards against the insult caused by ROS during the pathogenesis of the disease and antileprosy chemotherapy. DESIGN: Untreated leprosy patients were selected on the basis of clinical examination and skin smear. All diagnosed untreated leprosy patients received multi drug therapy (MDT) consisting of rifampicin, dapsone and clofazimine as recommended by World Health Organization. A small number of untreated cases were selected for co-supplementation of vitamin E along with MDT. Oxidative stress indices, enzymatic and nonenzymatic antioxidant status were assayed in untreated, MDT treated and those supplemented vitamin E along with MDT. STATISTICAL METHODS: We have compared the significance in the mean+/-s.d. values of the oxidative stress indices and the levels of antioxidants using one way analysis of variance (ANOVA) between control, untreated, MDT treated and those supplemented vitamin E with MDT and the results were significant at P < 0.05. Statistical analysis of the results suggests that oral administration of vitamin E lowers oxidative stress and augments antioxidant status in affected individuals. RESULTS: Enhanced oxidative stress as evidenced by increased LPO and protein carbonyl in leprosy cases lowers the antioxidant status. Treatment with MDT has a limited impact on increased oxidative stress and decreased antioxidant status. Coadministration of vitamin E along with MDT decreases oxidative stress and activate the antioxidant status. DISCUSSION: The excess production of ROS as seen in leprosy cases could lead to degeneration of tissues and derangement of internal organs. The possible reason for the decreased antioxidant status in leprosy cases may be increased production of ROS, deranged liver function, and the free radical producing ability of drugs used in MDT of leprosy. Intervention with antioxidant supplementation like vitamin E prevents oxidative stress mediated through ROS and activates the net antioxidant status during the chronic course of the disease and antileprosy chemotherapy. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16015260/Protective_role_of_vitamin_E_on_the_oxidative_stress_in_Hansen's_disease__Leprosy__patients_ DB - PRIME DP - Unbound Medicine ER -