Tags

Type your tag names separated by a space and hit enter

Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes.
Eur J Clin Nutr. 2005 Sep; 59(9):1071-80.EJ

Abstract

OBJECTIVE

Due to inconsistent results based on dietary intake data, unsaturated fatty acids in red blood cell (RBC) membranes and diet were used to investigate their association with allergic sensitisation and allergic rhinitis.

DESIGN

Cross-sectional, population-based study.

SETTING

Bavarian Nutrition Survey II (2002-03), Germany.

SUBJECTS

A total of 568 adult participants, 325 women and 243 men.

METHODS

By means of logistic regression models, the relation of fatty acids to (i) allergic sensitisation as defined by means of specific serum immunoglobulin E analysis (CAPSX1 class > or = 2), and (ii) self-reported allergic rhinitis was examined.

RESULTS

A high cell membrane level of eicosapentaenoic acid (EPA, 20:5 n-3) was inversely associated with allergic sensitisation, the adjusted odds ratio (OR) and 95% confidence interval (95% CI) were 0.52 (0.30-0.90) for the highest (vs lowest) quartile. A similar effect was observed for allergic rhinitis with an OR (95% CI) of 0.50 (0.24-1.03; P = 0.027 for trend). A higher dietary intake of alpha-linolenic acid (ALA, 18:3 n-3) was associated with a decreased risk of allergic sensitisation and allergic rhinitis with ORs (95% CIs) of 0.51 (0.28-0.93) and 0.43 (0.20-0.93), respectively, in the highest quartiles. No other dietary or cell membrane unsaturated fatty acid was significantly associated with the outcome variables, nor was the n-6/n-3 ratio. The strongest effects were observed among subjects under the age of 40 y.

CONCLUSIONS

In this cross-sectional study among adults, a high content of n-3 fatty acids in RBC membranes (EPA) or in the diet (ALA) is associated with a decreased risk of allergic sensitisation and allergic rhinitis.

Authors+Show Affiliations

Unit of Human Nutrition and Cancer Prevention, Technical University of Munich, Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16015268

Citation

Hoff, S, et al. "Allergic Sensitisation and Allergic Rhinitis Are Associated With N-3 Polyunsaturated Fatty Acids in the Diet and in Red Blood Cell Membranes." European Journal of Clinical Nutrition, vol. 59, no. 9, 2005, pp. 1071-80.
Hoff S, Seiler H, Heinrich J, et al. Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes. Eur J Clin Nutr. 2005;59(9):1071-80.
Hoff, S., Seiler, H., Heinrich, J., Kompauer, I., Nieters, A., Becker, N., Nagel, G., Gedrich, K., Karg, G., Wolfram, G., & Linseisen, J. (2005). Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes. European Journal of Clinical Nutrition, 59(9), 1071-80.
Hoff S, et al. Allergic Sensitisation and Allergic Rhinitis Are Associated With N-3 Polyunsaturated Fatty Acids in the Diet and in Red Blood Cell Membranes. Eur J Clin Nutr. 2005;59(9):1071-80. PubMed PMID: 16015268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Allergic sensitisation and allergic rhinitis are associated with n-3 polyunsaturated fatty acids in the diet and in red blood cell membranes. AU - Hoff,S, AU - Seiler,H, AU - Heinrich,J, AU - Kompauer,I, AU - Nieters,A, AU - Becker,N, AU - Nagel,G, AU - Gedrich,K, AU - Karg,G, AU - Wolfram,G, AU - Linseisen,J, PY - 2005/7/15/pubmed PY - 2005/12/13/medline PY - 2005/7/15/entrez SP - 1071 EP - 80 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 59 IS - 9 N2 - OBJECTIVE: Due to inconsistent results based on dietary intake data, unsaturated fatty acids in red blood cell (RBC) membranes and diet were used to investigate their association with allergic sensitisation and allergic rhinitis. DESIGN: Cross-sectional, population-based study. SETTING: Bavarian Nutrition Survey II (2002-03), Germany. SUBJECTS: A total of 568 adult participants, 325 women and 243 men. METHODS: By means of logistic regression models, the relation of fatty acids to (i) allergic sensitisation as defined by means of specific serum immunoglobulin E analysis (CAPSX1 class > or = 2), and (ii) self-reported allergic rhinitis was examined. RESULTS: A high cell membrane level of eicosapentaenoic acid (EPA, 20:5 n-3) was inversely associated with allergic sensitisation, the adjusted odds ratio (OR) and 95% confidence interval (95% CI) were 0.52 (0.30-0.90) for the highest (vs lowest) quartile. A similar effect was observed for allergic rhinitis with an OR (95% CI) of 0.50 (0.24-1.03; P = 0.027 for trend). A higher dietary intake of alpha-linolenic acid (ALA, 18:3 n-3) was associated with a decreased risk of allergic sensitisation and allergic rhinitis with ORs (95% CIs) of 0.51 (0.28-0.93) and 0.43 (0.20-0.93), respectively, in the highest quartiles. No other dietary or cell membrane unsaturated fatty acid was significantly associated with the outcome variables, nor was the n-6/n-3 ratio. The strongest effects were observed among subjects under the age of 40 y. CONCLUSIONS: In this cross-sectional study among adults, a high content of n-3 fatty acids in RBC membranes (EPA) or in the diet (ALA) is associated with a decreased risk of allergic sensitisation and allergic rhinitis. SN - 0954-3007 UR - https://www.unboundmedicine.com/medline/citation/16015268/Allergic_sensitisation_and_allergic_rhinitis_are_associated_with_n_3_polyunsaturated_fatty_acids_in_the_diet_and_in_red_blood_cell_membranes_ L2 - https://doi.org/10.1038/sj.ejcn.1602213 DB - PRIME DP - Unbound Medicine ER -