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HbA1c: a comparison of NGSP with IFCC transformed values.
Clin Chim Acta. 2005 Aug; 358(1-2):81-6.CC

Abstract

BACKGROUND

An approved IFCC reference method for measuring HbA1c, with a firm and reproducible correlation with NGSP values, is now available. We established (i) the degree of agreement of HbA1c results between the NGSP-certified and the IFCC-calibrated (converted to NGSP values) immunochemical method and (ii) the difference in the classification of control of diabetes mellitus (DM) in individual patients between the methods.

METHODS

HbA1c was measured on the same hemolysate from each patient by both methods (n=92). Results were analyzed by the kappa statistic, linear regression, and McNemar's chi(2) test.

RESULTS

Both methods achieved acceptable analytical performance. The kappa statistic measure of agreement was 0.65 and r(2)=0.937. Overall, 21 (22.8%) patients were classified differently in the extent of diabetes control (good, acceptable, or poor), with a significant difference between the 2 methods (p<0.0005).

CONCLUSIONS

The IFCC converted to NGSP values were significantly different from the previously used NGSP-certified method. The differences between the 2 methods are of sufficient magnitude that HbA1c results from these methods are not interchangeable. The IFCC method being scientifically superior in concept and design should replace the NGSP method. New HbA1c targets for DM management need to be established for the IFCC method.

Authors+Show Affiliations

Department of Pathology, Tawam Hospital, P.O. Box 15258, Al Ain, Abu Dhabi, United Arab Emirates. gurdeep1@emirates.net.aeNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

16018879

Citation

Dhatt, Gurdeep Singh, et al. "HbA1c: a Comparison of NGSP With IFCC Transformed Values." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 358, no. 1-2, 2005, pp. 81-6.
Dhatt GS, Agarwal MM, Bishawi B. HbA1c: a comparison of NGSP with IFCC transformed values. Clin Chim Acta. 2005;358(1-2):81-6.
Dhatt, G. S., Agarwal, M. M., & Bishawi, B. (2005). HbA1c: a comparison of NGSP with IFCC transformed values. Clinica Chimica Acta; International Journal of Clinical Chemistry, 358(1-2), 81-6.
Dhatt GS, Agarwal MM, Bishawi B. HbA1c: a Comparison of NGSP With IFCC Transformed Values. Clin Chim Acta. 2005;358(1-2):81-6. PubMed PMID: 16018879.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HbA1c: a comparison of NGSP with IFCC transformed values. AU - Dhatt,Gurdeep Singh, AU - Agarwal,Mukesh M, AU - Bishawi,Bassam, Y1 - 2005/04/15/ PY - 2004/10/19/received PY - 2005/02/07/revised PY - 2005/02/08/accepted PY - 2005/7/16/pubmed PY - 2005/12/16/medline PY - 2005/7/16/entrez SP - 81 EP - 6 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin Chim Acta VL - 358 IS - 1-2 N2 - BACKGROUND: An approved IFCC reference method for measuring HbA1c, with a firm and reproducible correlation with NGSP values, is now available. We established (i) the degree of agreement of HbA1c results between the NGSP-certified and the IFCC-calibrated (converted to NGSP values) immunochemical method and (ii) the difference in the classification of control of diabetes mellitus (DM) in individual patients between the methods. METHODS: HbA1c was measured on the same hemolysate from each patient by both methods (n=92). Results were analyzed by the kappa statistic, linear regression, and McNemar's chi(2) test. RESULTS: Both methods achieved acceptable analytical performance. The kappa statistic measure of agreement was 0.65 and r(2)=0.937. Overall, 21 (22.8%) patients were classified differently in the extent of diabetes control (good, acceptable, or poor), with a significant difference between the 2 methods (p<0.0005). CONCLUSIONS: The IFCC converted to NGSP values were significantly different from the previously used NGSP-certified method. The differences between the 2 methods are of sufficient magnitude that HbA1c results from these methods are not interchangeable. The IFCC method being scientifically superior in concept and design should replace the NGSP method. New HbA1c targets for DM management need to be established for the IFCC method. SN - 0009-8981 UR - https://www.unboundmedicine.com/medline/citation/16018879/HbA1c:_a_comparison_of_NGSP_with_IFCC_transformed_values_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(05)00109-9 DB - PRIME DP - Unbound Medicine ER -