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Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A.
Biochem Biophys Res Commun. 2005 Aug 26; 334(2):729-32.BB

Abstract

A G-protein coupled receptor to niacin (nicotinic acid) was identified recently but the physiological/pharmacological role of the receptor remains poorly defined. We present our studies to demonstrate that HM74A, but not HM74, binds niacin at high affinities and effectively mediates Gi signaling events in human embryonic kidney HEK293 cells as well as in 3T3L1 adipocytes expressing HM74A. Furthermore, HM74A, but not HM74, expressed in differentiated 3T3L1 adipocytes effectively mediated inhibition of lipolysis by niacin. Our results provided direct evidence indicating that HM74A, but not HM74, was sufficient to mediate anti-lipolytic effect of niacin in adipose tissue.

Authors+Show Affiliations

Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16018973

Citation

Zhang, Youyan, et al. "Niacin Mediates Lipolysis in Adipose Tissue Through Its G-protein Coupled Receptor HM74A." Biochemical and Biophysical Research Communications, vol. 334, no. 2, 2005, pp. 729-32.
Zhang Y, Schmidt RJ, Foxworthy P, et al. Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A. Biochem Biophys Res Commun. 2005;334(2):729-32.
Zhang, Y., Schmidt, R. J., Foxworthy, P., Emkey, R., Oler, J. K., Large, T. H., Wang, H., Su, E. W., Mosior, M. K., Eacho, P. I., & Cao, G. (2005). Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A. Biochemical and Biophysical Research Communications, 334(2), 729-32.
Zhang Y, et al. Niacin Mediates Lipolysis in Adipose Tissue Through Its G-protein Coupled Receptor HM74A. Biochem Biophys Res Commun. 2005 Aug 26;334(2):729-32. PubMed PMID: 16018973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A. AU - Zhang,Youyan, AU - Schmidt,Robert J, AU - Foxworthy,Patricia, AU - Emkey,Renee, AU - Oler,Jennifer K, AU - Large,Thomas H, AU - Wang,He, AU - Su,Eric W, AU - Mosior,Marion K, AU - Eacho,Patrick I, AU - Cao,Guoqing, PY - 2005/06/13/received PY - 2005/06/21/accepted PY - 2005/7/16/pubmed PY - 2005/9/27/medline PY - 2005/7/16/entrez SP - 729 EP - 32 JF - Biochemical and biophysical research communications JO - Biochem Biophys Res Commun VL - 334 IS - 2 N2 - A G-protein coupled receptor to niacin (nicotinic acid) was identified recently but the physiological/pharmacological role of the receptor remains poorly defined. We present our studies to demonstrate that HM74A, but not HM74, binds niacin at high affinities and effectively mediates Gi signaling events in human embryonic kidney HEK293 cells as well as in 3T3L1 adipocytes expressing HM74A. Furthermore, HM74A, but not HM74, expressed in differentiated 3T3L1 adipocytes effectively mediated inhibition of lipolysis by niacin. Our results provided direct evidence indicating that HM74A, but not HM74, was sufficient to mediate anti-lipolytic effect of niacin in adipose tissue. SN - 0006-291X UR - https://www.unboundmedicine.com/medline/citation/16018973/Niacin_mediates_lipolysis_in_adipose_tissue_through_its_G_protein_coupled_receptor_HM74A_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-291X(05)01338-0 DB - PRIME DP - Unbound Medicine ER -