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Postmenopausal bone mineral density in relation to soy isoflavone-metabolizing phenotypes.
Maturitas. 2006 Feb 20; 53(3):315-24.M

Abstract

OBJECTIVES

Intestinal bacterial metabolize the soy isoflavone daidzein to O-desmethylangolensin (O-DMA) or equol. Some individuals do not excrete O-DMA or equol after soy consumption, suggesting they do not harbor bacteria capable of producing these metabolites. The aim of this study was to evaluate bone mineral density (BMD) in relation to presence of these urinary metabolites.

METHODS

BMD, determined by whole-body dual X-ray absorptiometry scan, was age-adjusted and evaluated in relation to O-DMA-producer and equol-producer phenotypes in 92 postmenopausal women, aged 50-75 years. Women consumed supplemental soy foods (daidzein source) for 3 days and collected a first-void urine sample on the fourth day in order to determine metabolic phenotypes.

RESULTS

In O-DMA producers (n=76) compared to O-DMA non-producers (n=16), greater total, leg and head BMD (p<0.05) were observed. Total BMD among the O-DMA producers (geometric mean=1.04 g/cm2) was 6% greater than total BMD among the O-DMA non-producers (geometric mean=0.98 g/cm2). Total and site-specific BMD did not differ between equol producers (n=24) and non-producers (n=68) (p>0.05). In exploratory analyses, among regular soy consumers, spinal BMD was 20% lower among the equol producers than non-producers, whereas, among soy non-consumers, no such difference was observed (p-interaction<0.05). Among equol producers, circulating estrone and free estradiol concentrations were inversely or not associated with total BMD, whereas, among equol non-producers, these hormones were positively associated (p-interaction<0.05).

CONCLUSIONS

Our results provide evidence that intestinal bacterial composition may influence BMD in postmenopausal women. Further studies characterizing associations of intestinal bacterial profiles with BMD are warranted.

Authors+Show Affiliations

Cancer Prevention Program, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N., M4-B402, PO Box 19024, Seattle, WA 98109-1024, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

16019168

Citation

Frankenfeld, Cara L., et al. "Postmenopausal Bone Mineral Density in Relation to Soy Isoflavone-metabolizing Phenotypes." Maturitas, vol. 53, no. 3, 2006, pp. 315-24.
Frankenfeld CL, McTiernan A, Thomas WK, et al. Postmenopausal bone mineral density in relation to soy isoflavone-metabolizing phenotypes. Maturitas. 2006;53(3):315-24.
Frankenfeld, C. L., McTiernan, A., Thomas, W. K., LaCroix, K., McVarish, L., Holt, V. L., Schwartz, S. M., & Lampe, J. W. (2006). Postmenopausal bone mineral density in relation to soy isoflavone-metabolizing phenotypes. Maturitas, 53(3), 315-24.
Frankenfeld CL, et al. Postmenopausal Bone Mineral Density in Relation to Soy Isoflavone-metabolizing Phenotypes. Maturitas. 2006 Feb 20;53(3):315-24. PubMed PMID: 16019168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postmenopausal bone mineral density in relation to soy isoflavone-metabolizing phenotypes. AU - Frankenfeld,Cara L, AU - McTiernan,Anne, AU - Thomas,Wendy K, AU - LaCroix,Kristin, AU - McVarish,Lynda, AU - Holt,Victoria L, AU - Schwartz,Stephen M, AU - Lampe,Johanna W, Y1 - 2005/07/12/ PY - 2005/02/09/received PY - 2005/05/09/revised PY - 2005/05/25/accepted PY - 2005/7/16/pubmed PY - 2006/7/14/medline PY - 2005/7/16/entrez SP - 315 EP - 24 JF - Maturitas JO - Maturitas VL - 53 IS - 3 N2 - OBJECTIVES: Intestinal bacterial metabolize the soy isoflavone daidzein to O-desmethylangolensin (O-DMA) or equol. Some individuals do not excrete O-DMA or equol after soy consumption, suggesting they do not harbor bacteria capable of producing these metabolites. The aim of this study was to evaluate bone mineral density (BMD) in relation to presence of these urinary metabolites. METHODS: BMD, determined by whole-body dual X-ray absorptiometry scan, was age-adjusted and evaluated in relation to O-DMA-producer and equol-producer phenotypes in 92 postmenopausal women, aged 50-75 years. Women consumed supplemental soy foods (daidzein source) for 3 days and collected a first-void urine sample on the fourth day in order to determine metabolic phenotypes. RESULTS: In O-DMA producers (n=76) compared to O-DMA non-producers (n=16), greater total, leg and head BMD (p<0.05) were observed. Total BMD among the O-DMA producers (geometric mean=1.04 g/cm2) was 6% greater than total BMD among the O-DMA non-producers (geometric mean=0.98 g/cm2). Total and site-specific BMD did not differ between equol producers (n=24) and non-producers (n=68) (p>0.05). In exploratory analyses, among regular soy consumers, spinal BMD was 20% lower among the equol producers than non-producers, whereas, among soy non-consumers, no such difference was observed (p-interaction<0.05). Among equol producers, circulating estrone and free estradiol concentrations were inversely or not associated with total BMD, whereas, among equol non-producers, these hormones were positively associated (p-interaction<0.05). CONCLUSIONS: Our results provide evidence that intestinal bacterial composition may influence BMD in postmenopausal women. Further studies characterizing associations of intestinal bacterial profiles with BMD are warranted. SN - 0378-5122 UR - https://www.unboundmedicine.com/medline/citation/16019168/Postmenopausal_bone_mineral_density_in_relation_to_soy_isoflavone_metabolizing_phenotypes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5122(05)00122-2 DB - PRIME DP - Unbound Medicine ER -