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Bioassay-guided isolation of iridoid glucosides with antinociceptive and anti-inflammatory activities from Veronica anagallis-aquatica L.
J Ethnopharmacol. 2005 Nov 14; 102(2):170-6.JE

Abstract

Extracts obtained from the herbs of various Veronica species are used as folk remedy worldwide for the treatment of various inflammatory ailments including rheumatism. In vivo anti-inflammatory and antinociceptive activities of Veronica anagallis-aquatica L. aerial parts were investigated. Methanolic extract of the plant was shown to possess significant inhibitory activity against carrageenan-induced hind paw edema model and of p-benzoquinone-induced writhings in mice. Through bioassay-guided fractionation and isolation procedures eight compounds, aquaticoside A (1), aquaticoside B (2), aquaticoside C (3), veronicoside (4), catalposide (5), verproside (6), verminoside (7) and martynoside (8) were isolated and their structures were elucidated by spectral techniques. Catapol derivative iridoid glucosides, verproside (6) and catalposide (5), were found to possess potent antinociceptive and anti-inflammatory activities, per os without inducing any apparent acute toxicity as well as gastric damage. Results of the present study supported the utilization of the plant in Turkish folk medicine.

Authors+Show Affiliations

Gazi University, Faculty of Pharmacy, Etiler 06330 Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16019176

Citation

Küpeli, Esra, et al. "Bioassay-guided Isolation of Iridoid Glucosides With Antinociceptive and Anti-inflammatory Activities From Veronica Anagallis-aquatica L." Journal of Ethnopharmacology, vol. 102, no. 2, 2005, pp. 170-6.
Küpeli E, Harput US, Varel M, et al. Bioassay-guided isolation of iridoid glucosides with antinociceptive and anti-inflammatory activities from Veronica anagallis-aquatica L. J Ethnopharmacol. 2005;102(2):170-6.
Küpeli, E., Harput, U. S., Varel, M., Yesilada, E., & Saracoglu, I. (2005). Bioassay-guided isolation of iridoid glucosides with antinociceptive and anti-inflammatory activities from Veronica anagallis-aquatica L. Journal of Ethnopharmacology, 102(2), 170-6.
Küpeli E, et al. Bioassay-guided Isolation of Iridoid Glucosides With Antinociceptive and Anti-inflammatory Activities From Veronica Anagallis-aquatica L. J Ethnopharmacol. 2005 Nov 14;102(2):170-6. PubMed PMID: 16019176.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bioassay-guided isolation of iridoid glucosides with antinociceptive and anti-inflammatory activities from Veronica anagallis-aquatica L. AU - Küpeli,Esra, AU - Harput,U Sebnem, AU - Varel,Mehtap, AU - Yesilada,Erdem, AU - Saracoglu,Iclal, Y1 - 2005/07/12/ PY - 2004/09/24/received PY - 2005/05/11/revised PY - 2005/05/26/accepted PY - 2005/7/16/pubmed PY - 2006/3/17/medline PY - 2005/7/16/entrez SP - 170 EP - 6 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 102 IS - 2 N2 - Extracts obtained from the herbs of various Veronica species are used as folk remedy worldwide for the treatment of various inflammatory ailments including rheumatism. In vivo anti-inflammatory and antinociceptive activities of Veronica anagallis-aquatica L. aerial parts were investigated. Methanolic extract of the plant was shown to possess significant inhibitory activity against carrageenan-induced hind paw edema model and of p-benzoquinone-induced writhings in mice. Through bioassay-guided fractionation and isolation procedures eight compounds, aquaticoside A (1), aquaticoside B (2), aquaticoside C (3), veronicoside (4), catalposide (5), verproside (6), verminoside (7) and martynoside (8) were isolated and their structures were elucidated by spectral techniques. Catapol derivative iridoid glucosides, verproside (6) and catalposide (5), were found to possess potent antinociceptive and anti-inflammatory activities, per os without inducing any apparent acute toxicity as well as gastric damage. Results of the present study supported the utilization of the plant in Turkish folk medicine. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16019176/Bioassay_guided_isolation_of_iridoid_glucosides_with_antinociceptive_and_anti_inflammatory_activities_from_Veronica_anagallis_aquatica_L_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(05)00368-5 DB - PRIME DP - Unbound Medicine ER -