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Polycystic ovary syndrome and gynecological cancers: is there a link?
Gynecol Endocrinol 2005; 20(4):200-8GE

Abstract

Polycystic ovary syndrome [PCOS] is the most common endocrinopathy of women in reproductive age. An association between PCOS and type-1 endometrial cancer has often been reported in the literature. The prolonged anovulation with consequent continued secretion of estrogen unopposed by progesterone may enhance the development and growth of this malignancy, particularly in young women. Hypersecretion of luteinizing hormone [LH], chronic hyperinsulinemia and increased serum insulin-like growth factor [IGF]-I levels may represent risk factors for endometrial cancer. However, data available in the literature do not allow a meta-analysis to be carried out to calculate an estimate of the relative risk of endometrial cancer in women with PCOS. Anecdotal cases of low-grade endometrial stromal sarcoma and carcinosarcoma have been reported in association with prolonged unopposed estrogen stimulation, and in particular with PCOS. A few studies have addressed the possibility of an association between PCOS and epithelial ovarian cancer risk, and the results are conflicting but generally reassuring, and similarly the few available data appear to exclude a strong association between PCOS and breast cancer.

Authors+Show Affiliations

Department of Procreative Medicine and Child Development, Division of Gynecology and Obstetrics, University of Pisa, Italy. a.gadducci@obgyn.med.unipi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16019362

Citation

Gadducci, Angiolo, et al. "Polycystic Ovary Syndrome and Gynecological Cancers: Is There a Link?" Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 20, no. 4, 2005, pp. 200-8.
Gadducci A, Gargini A, Palla E, et al. Polycystic ovary syndrome and gynecological cancers: is there a link? Gynecol Endocrinol. 2005;20(4):200-8.
Gadducci, A., Gargini, A., Palla, E., Fanucchi, A., & Genazzani, A. R. (2005). Polycystic ovary syndrome and gynecological cancers: is there a link? Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 20(4), pp. 200-8.
Gadducci A, et al. Polycystic Ovary Syndrome and Gynecological Cancers: Is There a Link. Gynecol Endocrinol. 2005;20(4):200-8. PubMed PMID: 16019362.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polycystic ovary syndrome and gynecological cancers: is there a link? AU - Gadducci,Angiolo, AU - Gargini,Antonio, AU - Palla,Elisabetta, AU - Fanucchi,Antonio, AU - Genazzani,Andrea Riccardo, PY - 2005/7/16/pubmed PY - 2005/9/30/medline PY - 2005/7/16/entrez SP - 200 EP - 8 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 20 IS - 4 N2 - Polycystic ovary syndrome [PCOS] is the most common endocrinopathy of women in reproductive age. An association between PCOS and type-1 endometrial cancer has often been reported in the literature. The prolonged anovulation with consequent continued secretion of estrogen unopposed by progesterone may enhance the development and growth of this malignancy, particularly in young women. Hypersecretion of luteinizing hormone [LH], chronic hyperinsulinemia and increased serum insulin-like growth factor [IGF]-I levels may represent risk factors for endometrial cancer. However, data available in the literature do not allow a meta-analysis to be carried out to calculate an estimate of the relative risk of endometrial cancer in women with PCOS. Anecdotal cases of low-grade endometrial stromal sarcoma and carcinosarcoma have been reported in association with prolonged unopposed estrogen stimulation, and in particular with PCOS. A few studies have addressed the possibility of an association between PCOS and epithelial ovarian cancer risk, and the results are conflicting but generally reassuring, and similarly the few available data appear to exclude a strong association between PCOS and breast cancer. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/16019362/Polycystic_ovary_syndrome_and_gynecological_cancers:_is_there_a_link L2 - http://www.tandfonline.com/doi/full/10.1080/09513590400021201 DB - PRIME DP - Unbound Medicine ER -