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Role of postmenopausal hormone replacement therapy on body fat gain and leptin levels.
Gynecol Endocrinol. 2005 Apr; 20(4):227-35.GE

Abstract

During menopause women tend to gain body fat. The increase in adiposity seems to be a consequence of the decline in endogenous estrogens and the reduced energy expenditure. The role of post-menopausal hormone replacement therapy (pHT) in modulating visceral obesity is controversial. Some studies have shown that pHT has no effect on body weight while in other studies pHT increased body weight. Leptin is an adipocyte-derived hormone and its levels reflect the amount of adipose tissue. Obesity is associated with elevated serum leptin levels. The effect of pHT on leptin levels is also controversial. In some studies pHT increased leptin levels while other studies have not confirmed this increasing effect. The major problem encountered during administration of hormone therapy seems to be the timing of pHT initiation which is a strong confounder on the effect of pHT on leptin levels in postmenopausal women.

Authors+Show Affiliations

Second Department of Obstetrics and Gynecology, Aretaieion Hospital, University of Athens, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16019366

Citation

Augoulea, Areti, et al. "Role of Postmenopausal Hormone Replacement Therapy On Body Fat Gain and Leptin Levels." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 20, no. 4, 2005, pp. 227-35.
Augoulea A, Mastorakos G, Lambrinoudaki I, et al. Role of postmenopausal hormone replacement therapy on body fat gain and leptin levels. Gynecol Endocrinol. 2005;20(4):227-35.
Augoulea, A., Mastorakos, G., Lambrinoudaki, I., Christodoulakos, G., & Creatsas, G. (2005). Role of postmenopausal hormone replacement therapy on body fat gain and leptin levels. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 20(4), 227-35.
Augoulea A, et al. Role of Postmenopausal Hormone Replacement Therapy On Body Fat Gain and Leptin Levels. Gynecol Endocrinol. 2005;20(4):227-35. PubMed PMID: 16019366.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of postmenopausal hormone replacement therapy on body fat gain and leptin levels. AU - Augoulea,Areti, AU - Mastorakos,George, AU - Lambrinoudaki,Irene, AU - Christodoulakos,George, AU - Creatsas,George, PY - 2005/7/16/pubmed PY - 2005/9/30/medline PY - 2005/7/16/entrez SP - 227 EP - 35 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol Endocrinol VL - 20 IS - 4 N2 - During menopause women tend to gain body fat. The increase in adiposity seems to be a consequence of the decline in endogenous estrogens and the reduced energy expenditure. The role of post-menopausal hormone replacement therapy (pHT) in modulating visceral obesity is controversial. Some studies have shown that pHT has no effect on body weight while in other studies pHT increased body weight. Leptin is an adipocyte-derived hormone and its levels reflect the amount of adipose tissue. Obesity is associated with elevated serum leptin levels. The effect of pHT on leptin levels is also controversial. In some studies pHT increased leptin levels while other studies have not confirmed this increasing effect. The major problem encountered during administration of hormone therapy seems to be the timing of pHT initiation which is a strong confounder on the effect of pHT on leptin levels in postmenopausal women. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/16019366/Role_of_postmenopausal_hormone_replacement_therapy_on_body_fat_gain_and_leptin_levels_ L2 - https://www.tandfonline.com/doi/full/10.1080/09513590400027372 DB - PRIME DP - Unbound Medicine ER -