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Levels of lipoprotein and homocysteine in non-obese and obese patients with polycystic ovary syndrome.

Abstract

AIM

This study was designed to examine the relationship between homocysteine (Hcy), lipoprotein levels and insulin resistance in obese and non-obese patients with polycystic ovary syndrome (PCOS).

MATERIALS AND METHODS

Eighty-five patients (38 obese, 47 non-obese) with PCOS and 50 healthy subjects (25 obese, 25 non-obese) were included in the study. PCOS was defined according to the Homburg criterion. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEA-S), insulin, 17-hydroxyprogesterone, free testosterone, androstenedione, vitamin B12 and folate were measured. Also, serum concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), lipoprotein (a) (Lp(a)), apoprotein B (Apo B) and apoprotein A (Apo A) were determined. Plasma Hcy levels were measured. Insulin resistance was evaluated by homeostasis model assessment (HOMA).

RESULTS

Plasma Hcy levels were significantly higher in women with PCOS than in healthy women. HOMA-R (insulin resistance) was significantly higher in women with PCOS compared with healthy women. Serum fasting TC, LDL-C, TG, Apo B, vitamin B12 and folate levels were similar between PCOS and control groups. Lp(a) levels were higher in PCOS patients than in control subjects, whereas HDL-C and Apo A levels were lower. Compared with obese PCOS subjects, non-obese PCOS subjects had low HOMA-R, TC, LDL-C, TG, Apo B, Lp(a) and androgen levels. Plasma Hcy levels, serum HDL-C and Apo A levels were similar between obese and non-obese women with PCOS. Levels of HDL-C and Apo A were lower in both obese and non-obese PCOS patients than in obese and non-obese control subjects, whereas Lp(a) levels were higher. No correlation was observed between plasma Hcy, body mass index, HOMA-R, serum androgen levels, TC, LDL-C, HDL-C, Apo A, Apo B and Lp(a) levels.

CONCLUSION

These results showed that elevated insulin resistance and plasma Hcy levels, and changes in serum lipid profile, which are possible risk factors for cardiovascular disorders, play important roles in the development of cardiovascular disease in both obese and non-obese patients with PCOS.

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  • Authors+Show Affiliations

    ,

    Department of Endocrinology and Metabolism, Faculty of Medicine, Kirikkale University, Kirikkale, Turkey. murartt@hotmail.com

    , , , , ,

    Source

    MeSH

    17-alpha-Hydroxyprogesterone
    Adult
    Apolipoproteins A
    Apolipoproteins B
    Cardiovascular Diseases
    Case-Control Studies
    Cholesterol
    Cholesterol, HDL
    Cholesterol, LDL
    Dehydroepiandrosterone Sulfate
    Female
    Follicle Stimulating Hormone
    Homocysteine
    Humans
    Insulin
    Lipoprotein(a)
    Lipoproteins
    Luteinizing Hormone
    Obesity
    Polycystic Ovary Syndrome
    Testosterone
    Triglycerides

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    16019370

    Citation

    Yilmaz, Murat, et al. "Levels of Lipoprotein and Homocysteine in Non-obese and Obese Patients With Polycystic Ovary Syndrome." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 20, no. 5, 2005, pp. 258-63.
    Yilmaz M, Biri A, Bukan N, et al. Levels of lipoprotein and homocysteine in non-obese and obese patients with polycystic ovary syndrome. Gynecol Endocrinol. 2005;20(5):258-63.
    Yilmaz, M., Biri, A., Bukan, N., Karakoç, A., Sancak, B., Törüner, F., & Paşaoğlu, H. (2005). Levels of lipoprotein and homocysteine in non-obese and obese patients with polycystic ovary syndrome. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 20(5), pp. 258-63.
    Yilmaz M, et al. Levels of Lipoprotein and Homocysteine in Non-obese and Obese Patients With Polycystic Ovary Syndrome. Gynecol Endocrinol. 2005;20(5):258-63. PubMed PMID: 16019370.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Levels of lipoprotein and homocysteine in non-obese and obese patients with polycystic ovary syndrome. AU - Yilmaz,Murat, AU - Biri,Aydan, AU - Bukan,Neslihan, AU - Karakoç,Ayhan, AU - Sancak,Banu, AU - Törüner,Füsun, AU - Paşaoğlu,Hatice, PY - 2005/7/16/pubmed PY - 2005/10/21/medline PY - 2005/7/16/entrez SP - 258 EP - 63 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 20 IS - 5 N2 - AIM: This study was designed to examine the relationship between homocysteine (Hcy), lipoprotein levels and insulin resistance in obese and non-obese patients with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: Eighty-five patients (38 obese, 47 non-obese) with PCOS and 50 healthy subjects (25 obese, 25 non-obese) were included in the study. PCOS was defined according to the Homburg criterion. Serum levels of follicle-stimulating hormone (FSH), luteinizing hormone (LH), dehydroepiandrosterone sulfate (DHEA-S), insulin, 17-hydroxyprogesterone, free testosterone, androstenedione, vitamin B12 and folate were measured. Also, serum concentrations of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), lipoprotein (a) (Lp(a)), apoprotein B (Apo B) and apoprotein A (Apo A) were determined. Plasma Hcy levels were measured. Insulin resistance was evaluated by homeostasis model assessment (HOMA). RESULTS: Plasma Hcy levels were significantly higher in women with PCOS than in healthy women. HOMA-R (insulin resistance) was significantly higher in women with PCOS compared with healthy women. Serum fasting TC, LDL-C, TG, Apo B, vitamin B12 and folate levels were similar between PCOS and control groups. Lp(a) levels were higher in PCOS patients than in control subjects, whereas HDL-C and Apo A levels were lower. Compared with obese PCOS subjects, non-obese PCOS subjects had low HOMA-R, TC, LDL-C, TG, Apo B, Lp(a) and androgen levels. Plasma Hcy levels, serum HDL-C and Apo A levels were similar between obese and non-obese women with PCOS. Levels of HDL-C and Apo A were lower in both obese and non-obese PCOS patients than in obese and non-obese control subjects, whereas Lp(a) levels were higher. No correlation was observed between plasma Hcy, body mass index, HOMA-R, serum androgen levels, TC, LDL-C, HDL-C, Apo A, Apo B and Lp(a) levels. CONCLUSION: These results showed that elevated insulin resistance and plasma Hcy levels, and changes in serum lipid profile, which are possible risk factors for cardiovascular disorders, play important roles in the development of cardiovascular disease in both obese and non-obese patients with PCOS. SN - 0951-3590 UR - https://www.unboundmedicine.com/medline/citation/16019370/Levels_of_lipoprotein_and_homocysteine_in_non_obese_and_obese_patients_with_polycystic_ovary_syndrome_ L2 - http://www.tandfonline.com/doi/full/10.1080/09513590400027265 DB - PRIME DP - Unbound Medicine ER -