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Changes in cardiovascular autonomic regulation among elderly subjects: follow-up of sixteen years.
Ann Med. 2005; 37(3):206-12.AM

Abstract

BACKGROUND

Previous cross-sectional studies have suggested that cardiac autonomic regulation, measured as heart rate (HR) variability, is altered upon ageing, and that altered HR variability may predict mortality. However, there are no longitudinal follow-up reports of the changes of HR dynamics in elderly subjects.

AIM & METHOD

This study was designed to examine the longitudinal changes in the spectral, fractal, and complexity measures of HR variability in a random sample of 41 elderly subjects (mean age 69+/-4 years), who underwent repeated 24-hour Holter recordings at the baseline and after 16 years' follow-up. Several cardiovascular risk factors were determined at the baseline.

RESULTS

A time-domain index, standard deviation of N-N intervals (SDNN) (142+/-34 msec versus 133+/-50 msec, not significant (NS)), and the high frequency spectral component of HR variability (219+/-222 msec(2)versus 268+/-287 msec(2), NS) did not change during the follow-up. The low frequency power (LF) of HR variability decreased from 678+/-654 msec(2) to 436+/-651 msec(2) (P<0.01). Among the fractal HR variability indexes, the power-law slope (ss) (-1.31+/-0.20 versus -1.47+/-0.21, P<0.001) and the short-term fractal exponent a1 (1.16+/-0.19 versus 1.06+/-0.18, P<0.01) decreased significantly. Approximate entropy remained unchanged.

CONCLUSIONS

The magnitude of total HR variability and the respiratory vagal modulation of HR do not change over time in the elderly. However, the spectral and fractal characteristics of HR behavior still undergo alterations upon ageing.

Authors+Show Affiliations

Division of Cardiology, Department of Medicine, University of Oulu, Finland. vesa.jokinen@oulu.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16019719

Citation

Jokinen, Vesa, et al. "Changes in Cardiovascular Autonomic Regulation Among Elderly Subjects: Follow-up of Sixteen Years." Annals of Medicine, vol. 37, no. 3, 2005, pp. 206-12.
Jokinen V, Sourander LB, Karanko H, et al. Changes in cardiovascular autonomic regulation among elderly subjects: follow-up of sixteen years. Ann Med. 2005;37(3):206-12.
Jokinen, V., Sourander, L. B., Karanko, H., Mäkikallio, T. H., & Huikuri, H. V. (2005). Changes in cardiovascular autonomic regulation among elderly subjects: follow-up of sixteen years. Annals of Medicine, 37(3), 206-12.
Jokinen V, et al. Changes in Cardiovascular Autonomic Regulation Among Elderly Subjects: Follow-up of Sixteen Years. Ann Med. 2005;37(3):206-12. PubMed PMID: 16019719.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Changes in cardiovascular autonomic regulation among elderly subjects: follow-up of sixteen years. AU - Jokinen,Vesa, AU - Sourander,Leif B, AU - Karanko,Hannu, AU - Mäkikallio,Timo H, AU - Huikuri,Heikki V, PY - 2005/7/16/pubmed PY - 2005/9/28/medline PY - 2005/7/16/entrez SP - 206 EP - 12 JF - Annals of medicine JO - Ann Med VL - 37 IS - 3 N2 - BACKGROUND: Previous cross-sectional studies have suggested that cardiac autonomic regulation, measured as heart rate (HR) variability, is altered upon ageing, and that altered HR variability may predict mortality. However, there are no longitudinal follow-up reports of the changes of HR dynamics in elderly subjects. AIM & METHOD: This study was designed to examine the longitudinal changes in the spectral, fractal, and complexity measures of HR variability in a random sample of 41 elderly subjects (mean age 69+/-4 years), who underwent repeated 24-hour Holter recordings at the baseline and after 16 years' follow-up. Several cardiovascular risk factors were determined at the baseline. RESULTS: A time-domain index, standard deviation of N-N intervals (SDNN) (142+/-34 msec versus 133+/-50 msec, not significant (NS)), and the high frequency spectral component of HR variability (219+/-222 msec(2)versus 268+/-287 msec(2), NS) did not change during the follow-up. The low frequency power (LF) of HR variability decreased from 678+/-654 msec(2) to 436+/-651 msec(2) (P<0.01). Among the fractal HR variability indexes, the power-law slope (ss) (-1.31+/-0.20 versus -1.47+/-0.21, P<0.001) and the short-term fractal exponent a1 (1.16+/-0.19 versus 1.06+/-0.18, P<0.01) decreased significantly. Approximate entropy remained unchanged. CONCLUSIONS: The magnitude of total HR variability and the respiratory vagal modulation of HR do not change over time in the elderly. However, the spectral and fractal characteristics of HR behavior still undergo alterations upon ageing. SN - 0785-3890 UR - https://www.unboundmedicine.com/medline/citation/16019719/Changes_in_cardiovascular_autonomic_regulation_among_elderly_subjects:_follow_up_of_sixteen_years_ DB - PRIME DP - Unbound Medicine ER -