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Abrasive blasting agents: designing studies to evaluate relative risk.
J Toxicol Environ Health A. 2005 Jun 11-25; 68(11-12):999-1016.JT

Abstract

Workers exposed to respirable crystalline silica used in abrasive blasting are at increased risk of developing a debilitating and often fatal fibrotic lung disease called silicosis. The National Institute for Occupational Safety and Health (NIOSH) recommends that silica sand be prohibited as abrasive blasting material and that less hazardous materials be used in blasting operations. However, data are needed on the relative risks associated with exposure to abrasive blasting materials other than silica. NIOSH has completed acute studies in rats (Hubbs et al., 2001; Porter et al., 2002). To provide dose-response data applicable to making recommendation for occupational exposure limits, NIOSH has collaborated with the National Toxicology Program (NTP) to design longer term studies with silica substitutes. For risk assessment purposes, selected doses will include concentrations that are relevant to human exposures. Rat lung burdens achieved should be comparable to those estimated in humans with working lifetime exposures, even if this results in "overloading" doses in rats. To quantify both dose and response, retained particle burdens in the lungs and lung-associated lymph nodes will be measured, as well as biochemical and pathological indices of pulmonary response. This design will facilitate assessment of the pulmonary fibrogenic potential of inhaled abrasive blasting agents at occupationally relevant concentrations.

Authors+Show Affiliations

National Institute for Occupational Safety and Health, Morgantown, West Virginia, USA. AHubbs@cdc.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16020188

Citation

Hubbs, Ann, et al. "Abrasive Blasting Agents: Designing Studies to Evaluate Relative Risk." Journal of Toxicology and Environmental Health. Part A, vol. 68, no. 11-12, 2005, pp. 999-1016.
Hubbs A, Greskevitch M, Kuempel E, et al. Abrasive blasting agents: designing studies to evaluate relative risk. J Toxicol Environ Health A. 2005;68(11-12):999-1016.
Hubbs, A., Greskevitch, M., Kuempel, E., Suarez, F., & Toraason, M. (2005). Abrasive blasting agents: designing studies to evaluate relative risk. Journal of Toxicology and Environmental Health. Part A, 68(11-12), 999-1016.
Hubbs A, et al. Abrasive Blasting Agents: Designing Studies to Evaluate Relative Risk. J Toxicol Environ Health A. 2005 Jun 11-25;68(11-12):999-1016. PubMed PMID: 16020188.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Abrasive blasting agents: designing studies to evaluate relative risk. AU - Hubbs,Ann, AU - Greskevitch,Mark, AU - Kuempel,Eileen, AU - Suarez,Fernando, AU - Toraason,Mark, PY - 2005/7/16/pubmed PY - 2005/8/18/medline PY - 2005/7/16/entrez SP - 999 EP - 1016 JF - Journal of toxicology and environmental health. Part A JO - J Toxicol Environ Health A VL - 68 IS - 11-12 N2 - Workers exposed to respirable crystalline silica used in abrasive blasting are at increased risk of developing a debilitating and often fatal fibrotic lung disease called silicosis. The National Institute for Occupational Safety and Health (NIOSH) recommends that silica sand be prohibited as abrasive blasting material and that less hazardous materials be used in blasting operations. However, data are needed on the relative risks associated with exposure to abrasive blasting materials other than silica. NIOSH has completed acute studies in rats (Hubbs et al., 2001; Porter et al., 2002). To provide dose-response data applicable to making recommendation for occupational exposure limits, NIOSH has collaborated with the National Toxicology Program (NTP) to design longer term studies with silica substitutes. For risk assessment purposes, selected doses will include concentrations that are relevant to human exposures. Rat lung burdens achieved should be comparable to those estimated in humans with working lifetime exposures, even if this results in "overloading" doses in rats. To quantify both dose and response, retained particle burdens in the lungs and lung-associated lymph nodes will be measured, as well as biochemical and pathological indices of pulmonary response. This design will facilitate assessment of the pulmonary fibrogenic potential of inhaled abrasive blasting agents at occupationally relevant concentrations. SN - 1528-7394 UR - https://www.unboundmedicine.com/medline/citation/16020188/Abrasive_blasting_agents:_designing_studies_to_evaluate_relative_risk_ L2 - https://www.tandfonline.com/doi/full/10.1080/15287390590912612 DB - PRIME DP - Unbound Medicine ER -