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Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus.
Proc Natl Acad Sci U S A. 2005 Jul 26; 102(30):10718-23.PN

Abstract

Activation of beta-adrenoceptors in the basolateral complex of the amygdala (BLA) modulates memory storage processes and long-term potentiation in downstream targets of BLA efferents, including the hippocampus. Here, we show that this activation also increases hippocampal levels of activity-regulated cytoskeletal protein (Arc), an immediate-early gene (also termed Arg 3.1) implicated in hippocampal synaptic plasticity and memory consolidation processes. Infusions of the beta-adrenoreceptor agonist, clenbuterol, into the BLA immediately after training on an inhibitory avoidance task enhanced memory tested 48 h later. The same dose of clenbuterol significantly increased Arc protein levels in the dorsal hippocampus. Additionally, posttraining intra-BLA infusions of a memory-impairing dose of lidocaine significantly reduced Arc protein levels in the dorsal hippocampus. Increases in Arc protein levels were not accompanied by increases in Arc mRNA, suggesting that amygdala modulation of Arc protein and synaptic plasticity in efferent brain regions occurs at a posttranscriptional level. Finally, infusions of Arc antisense oligodeoxynucleotides into the dorsal hippocampus impaired performance of an inhibitory avoidance task, indicating that the changes in Arc protein expression are related to the observed changes in memory performance.

Authors+Show Affiliations

Center for the Neurobiology of Learning and Memory, and Department of Neurobiology and Behavior, 218 Bonney Research Laboratory, University of California, Irvine, CA 92697-3800, USA. cmcintyr@uci.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16020527

Citation

McIntyre, Christa K., et al. "Memory-influencing Intra-basolateral Amygdala Drug Infusions Modulate Expression of Arc Protein in the Hippocampus." Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 30, 2005, pp. 10718-23.
McIntyre CK, Miyashita T, Setlow B, et al. Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus. Proc Natl Acad Sci U S A. 2005;102(30):10718-23.
McIntyre, C. K., Miyashita, T., Setlow, B., Marjon, K. D., Steward, O., Guzowski, J. F., & McGaugh, J. L. (2005). Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America, 102(30), 10718-23.
McIntyre CK, et al. Memory-influencing Intra-basolateral Amygdala Drug Infusions Modulate Expression of Arc Protein in the Hippocampus. Proc Natl Acad Sci U S A. 2005 Jul 26;102(30):10718-23. PubMed PMID: 16020527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus. AU - McIntyre,Christa K, AU - Miyashita,Teiko, AU - Setlow,Barry, AU - Marjon,Kristopher D, AU - Steward,Oswald, AU - Guzowski,John F, AU - McGaugh,James L, Y1 - 2005/07/14/ PY - 2005/7/16/pubmed PY - 2005/12/31/medline PY - 2005/7/16/entrez SP - 10718 EP - 23 JF - Proceedings of the National Academy of Sciences of the United States of America JO - Proc Natl Acad Sci U S A VL - 102 IS - 30 N2 - Activation of beta-adrenoceptors in the basolateral complex of the amygdala (BLA) modulates memory storage processes and long-term potentiation in downstream targets of BLA efferents, including the hippocampus. Here, we show that this activation also increases hippocampal levels of activity-regulated cytoskeletal protein (Arc), an immediate-early gene (also termed Arg 3.1) implicated in hippocampal synaptic plasticity and memory consolidation processes. Infusions of the beta-adrenoreceptor agonist, clenbuterol, into the BLA immediately after training on an inhibitory avoidance task enhanced memory tested 48 h later. The same dose of clenbuterol significantly increased Arc protein levels in the dorsal hippocampus. Additionally, posttraining intra-BLA infusions of a memory-impairing dose of lidocaine significantly reduced Arc protein levels in the dorsal hippocampus. Increases in Arc protein levels were not accompanied by increases in Arc mRNA, suggesting that amygdala modulation of Arc protein and synaptic plasticity in efferent brain regions occurs at a posttranscriptional level. Finally, infusions of Arc antisense oligodeoxynucleotides into the dorsal hippocampus impaired performance of an inhibitory avoidance task, indicating that the changes in Arc protein expression are related to the observed changes in memory performance. SN - 0027-8424 UR - https://www.unboundmedicine.com/medline/citation/16020527/Memory_influencing_intra_basolateral_amygdala_drug_infusions_modulate_expression_of_Arc_protein_in_the_hippocampus_ L2 - http://www.pnas.org/cgi/pmidlookup?view=long&pmid=16020527 DB - PRIME DP - Unbound Medicine ER -