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Evaluation of various therapeutic schemes in the treatment of tinnitus due to acute acoustic trauma.
Kulak Burun Bogaz Ihtis Derg. 2004; 12(5-6):107-14.KB

Abstract

OBJECTIVES

We evaluated the effectiveness of various pharmaceutical therapeutic schemes in the treatment of tinnitus due to acute acoustic trauma.

PATIENTS AND METHODS

This prospective study included 108 military personnel (all males; mean age 22 years; range 18 to 31 years) with complaints of tinnitus due to acute acoustic trauma following firearm use. Involvement was in the left ear in 61 patients, the right ear in nine patients, and in both ears in 38 patients. The mean duration from trauma to treatment was 26 days (range 1 to 110 days). Before and after treatment, complaints of tinnitus were evaluated using a questionnaire and a visual analog scale. Treatment was carried out for 15 days in four randomized groups: oral administration of trimetazidine, prednisolone, and vitamin B complex; trimetazidine alone; prednisolone and vitamin B complex; and intravenous piracetam and prednisolone. Unresponsive patients were further treated with trimetazidine for a month. Evaluations were made 15 days and 45 days after the institution of treatment.

RESULTS

Thirteen patients (12%) had complete remission and 28 patients (25.9%) showed significant improvement. Further treatment with trimetazidine was beneficial in only seven (9.5%) patients. No significant differences were found between the groups in terms of tinnitus remission and improvement in hearing (p>0.05). Initiation of treatment, especially within the first week following acoustic trauma was significantly linked with higher rates of tinnitus regression (p<0.05). The degree of hearing improvement after medication did not correlate with improvement in tinnitus. Intravenous treatment was not advantageous over oral treatment.

CONCLUSION

A timely initiation of therapy, especially within the first week following acoustic trauma, increases the chance of improvement in tinnitus patients.

Authors+Show Affiliations

Department of Otolaryngology, AHEPA University Hospital, Aristotle University of Thessaloniki, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16020985

Citation

Markou, Konstantinos, et al. "Evaluation of Various Therapeutic Schemes in the Treatment of Tinnitus Due to Acute Acoustic Trauma." Kulak Burun Bogaz Ihtisas Dergisi : KBB = Journal of Ear, Nose, and Throat, vol. 12, no. 5-6, 2004, pp. 107-14.
Markou K, Nikolaou A, Petridis DG, et al. Evaluation of various therapeutic schemes in the treatment of tinnitus due to acute acoustic trauma. Kulak Burun Bogaz Ihtis Derg. 2004;12(5-6):107-14.
Markou, K., Nikolaou, A., Petridis, D. G., Vlachtsis, K. C., Kouloulas, A., & Daniilidis, I. C. (2004). Evaluation of various therapeutic schemes in the treatment of tinnitus due to acute acoustic trauma. Kulak Burun Bogaz Ihtisas Dergisi : KBB = Journal of Ear, Nose, and Throat, 12(5-6), 107-14.
Markou K, et al. Evaluation of Various Therapeutic Schemes in the Treatment of Tinnitus Due to Acute Acoustic Trauma. Kulak Burun Bogaz Ihtis Derg. 2004;12(5-6):107-14. PubMed PMID: 16020985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of various therapeutic schemes in the treatment of tinnitus due to acute acoustic trauma. AU - Markou,Konstantinos, AU - Nikolaou,Angelos, AU - Petridis,Dimitrios G, AU - Vlachtsis,Konstantinos C, AU - Kouloulas,Athanassios, AU - Daniilidis,Ioannis C, PY - 2005/7/16/pubmed PY - 2005/8/19/medline PY - 2005/7/16/entrez SP - 107 EP - 14 JF - Kulak burun bogaz ihtisas dergisi : KBB = Journal of ear, nose, and throat JO - Kulak Burun Bogaz Ihtis Derg VL - 12 IS - 5-6 N2 - OBJECTIVES: We evaluated the effectiveness of various pharmaceutical therapeutic schemes in the treatment of tinnitus due to acute acoustic trauma. PATIENTS AND METHODS: This prospective study included 108 military personnel (all males; mean age 22 years; range 18 to 31 years) with complaints of tinnitus due to acute acoustic trauma following firearm use. Involvement was in the left ear in 61 patients, the right ear in nine patients, and in both ears in 38 patients. The mean duration from trauma to treatment was 26 days (range 1 to 110 days). Before and after treatment, complaints of tinnitus were evaluated using a questionnaire and a visual analog scale. Treatment was carried out for 15 days in four randomized groups: oral administration of trimetazidine, prednisolone, and vitamin B complex; trimetazidine alone; prednisolone and vitamin B complex; and intravenous piracetam and prednisolone. Unresponsive patients were further treated with trimetazidine for a month. Evaluations were made 15 days and 45 days after the institution of treatment. RESULTS: Thirteen patients (12%) had complete remission and 28 patients (25.9%) showed significant improvement. Further treatment with trimetazidine was beneficial in only seven (9.5%) patients. No significant differences were found between the groups in terms of tinnitus remission and improvement in hearing (p>0.05). Initiation of treatment, especially within the first week following acoustic trauma was significantly linked with higher rates of tinnitus regression (p<0.05). The degree of hearing improvement after medication did not correlate with improvement in tinnitus. Intravenous treatment was not advantageous over oral treatment. CONCLUSION: A timely initiation of therapy, especially within the first week following acoustic trauma, increases the chance of improvement in tinnitus patients. SN - 1300-7475 UR - https://www.unboundmedicine.com/medline/citation/16020985/Evaluation_of_various_therapeutic_schemes_in_the_treatment_of_tinnitus_due_to_acute_acoustic_trauma_ L2 - http://www.diseaseinfosearch.org/result/9653 DB - PRIME DP - Unbound Medicine ER -