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Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia.
Am J Obstet Gynecol. 2005 Jul; 193(1):267-72.AJ

Abstract

OBJECTIVE

The purpose of this study was to determine the influence of reduced uteroplacental perfusion pressure on plasma leptin and placental leptin receptor expression in rats that develop hypertension in the third trimester of pregnancy.

STUDY DESIGN

The ovarian arteries and abdominal aortae of pregnant Sprague-Dawley rats (n=9) were constricted surgically on day 14 of gestation and were matched with sham controls. Systolic blood pressure and weight were measured biweekly. Maternal plasma leptin levels, placental leptin receptor abundance, fetal number, fetal weight, and placental weight were determined.

RESULTS

Reductions in perfusion pressure induced a significant decrease in maternal plasma leptin. Maternal systolic blood pressure and leptin receptor protein abundance was increased in the experimental group. Litter size and fetal and placental weight were significantly decreased in response to reduced perfusion pressure.

CONCLUSION

Reduced uteroplacental perfusion pressure reduces litter size, fetal and placental weights, and maternal plasma leptin levels and increases placental expression of leptin receptors.

Authors+Show Affiliations

College of Nursing and Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota, Grand Forks 58202, USA. cindyanderson@mail.und.nodak.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16021089

Citation

Anderson, Cindy M., et al. "Characterization of Changes in Leptin and Leptin Receptors in a Rat Model of Preeclampsia." American Journal of Obstetrics and Gynecology, vol. 193, no. 1, 2005, pp. 267-72.
Anderson CM, Lopez F, Zhang HY, et al. Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia. Am J Obstet Gynecol. 2005;193(1):267-72.
Anderson, C. M., Lopez, F., Zhang, H. Y., Pavlish, K., & Benoit, J. N. (2005). Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia. American Journal of Obstetrics and Gynecology, 193(1), 267-72.
Anderson CM, et al. Characterization of Changes in Leptin and Leptin Receptors in a Rat Model of Preeclampsia. Am J Obstet Gynecol. 2005;193(1):267-72. PubMed PMID: 16021089.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of changes in leptin and leptin receptors in a rat model of preeclampsia. AU - Anderson,Cindy M, AU - Lopez,Faye, AU - Zhang,Hai-Ying, AU - Pavlish,Kristin, AU - Benoit,Joseph N, PY - 2005/7/16/pubmed PY - 2005/8/12/medline PY - 2005/7/16/entrez SP - 267 EP - 72 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 193 IS - 1 N2 - OBJECTIVE: The purpose of this study was to determine the influence of reduced uteroplacental perfusion pressure on plasma leptin and placental leptin receptor expression in rats that develop hypertension in the third trimester of pregnancy. STUDY DESIGN: The ovarian arteries and abdominal aortae of pregnant Sprague-Dawley rats (n=9) were constricted surgically on day 14 of gestation and were matched with sham controls. Systolic blood pressure and weight were measured biweekly. Maternal plasma leptin levels, placental leptin receptor abundance, fetal number, fetal weight, and placental weight were determined. RESULTS: Reductions in perfusion pressure induced a significant decrease in maternal plasma leptin. Maternal systolic blood pressure and leptin receptor protein abundance was increased in the experimental group. Litter size and fetal and placental weight were significantly decreased in response to reduced perfusion pressure. CONCLUSION: Reduced uteroplacental perfusion pressure reduces litter size, fetal and placental weights, and maternal plasma leptin levels and increases placental expression of leptin receptors. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/16021089/Characterization_of_changes_in_leptin_and_leptin_receptors_in_a_rat_model_of_preeclampsia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002937804018812 DB - PRIME DP - Unbound Medicine ER -