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c-myc amplification is associated with HER2 amplification and closely linked with cell proliferation in tissue microarray of nonselected breast cancers.
Hum Pathol. 2005 Jun; 36(6):634-9.HP

Abstract

C-myc and HER2 amplification were analyzed on 214 consecutive breast cancers by fluorescence in situ hybridization using tissue microarray technology. The frequencies of amplification were 15.4% (33/214) and 23.3% (49/210), respectively. c- myc amplification was significantly associated with HER2 amplification (P < .001) and closely linked with cell proliferative activity, measured by Ki67 labeling index (P = .010). In univariate survival analysis, lymph node status, tumor size, and histological grade were significant prognostic factors, but in multivariate analysis, lymph node status was the only significant factor. Patient survival did not differ according to c- myc amplification status, and c- myc amplification showed no significant correlation with clinicopathologic features of the tumors. A strong correlation between c- myc and HER2 amplification and proliferative activity indicates a biological link between these genes in breast cancer cell.

Authors+Show Affiliations

Department of Pathology, Inje University Sanggye Paik Hospital, Seoul, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16021569

Citation

Park, Kyeongmee, et al. "C-myc Amplification Is Associated With HER2 Amplification and Closely Linked With Cell Proliferation in Tissue Microarray of Nonselected Breast Cancers." Human Pathology, vol. 36, no. 6, 2005, pp. 634-9.
Park K, Kwak K, Kim J, et al. C-myc amplification is associated with HER2 amplification and closely linked with cell proliferation in tissue microarray of nonselected breast cancers. Hum Pathol. 2005;36(6):634-9.
Park, K., Kwak, K., Kim, J., Lim, S., & Han, S. (2005). C-myc amplification is associated with HER2 amplification and closely linked with cell proliferation in tissue microarray of nonselected breast cancers. Human Pathology, 36(6), 634-9.
Park K, et al. C-myc Amplification Is Associated With HER2 Amplification and Closely Linked With Cell Proliferation in Tissue Microarray of Nonselected Breast Cancers. Hum Pathol. 2005;36(6):634-9. PubMed PMID: 16021569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - c-myc amplification is associated with HER2 amplification and closely linked with cell proliferation in tissue microarray of nonselected breast cancers. AU - Park,Kyeongmee, AU - Kwak,Keumhee, AU - Kim,Jungyeon, AU - Lim,Sungjig, AU - Han,Sehwan, PY - 2005/7/16/pubmed PY - 2005/8/27/medline PY - 2005/7/16/entrez SP - 634 EP - 9 JF - Human pathology JO - Hum. Pathol. VL - 36 IS - 6 N2 - C-myc and HER2 amplification were analyzed on 214 consecutive breast cancers by fluorescence in situ hybridization using tissue microarray technology. The frequencies of amplification were 15.4% (33/214) and 23.3% (49/210), respectively. c- myc amplification was significantly associated with HER2 amplification (P < .001) and closely linked with cell proliferative activity, measured by Ki67 labeling index (P = .010). In univariate survival analysis, lymph node status, tumor size, and histological grade were significant prognostic factors, but in multivariate analysis, lymph node status was the only significant factor. Patient survival did not differ according to c- myc amplification status, and c- myc amplification showed no significant correlation with clinicopathologic features of the tumors. A strong correlation between c- myc and HER2 amplification and proliferative activity indicates a biological link between these genes in breast cancer cell. SN - 0046-8177 UR - https://www.unboundmedicine.com/medline/citation/16021569/c_myc_amplification_is_associated_with_HER2_amplification_and_closely_linked_with_cell_proliferation_in_tissue_microarray_of_nonselected_breast_cancers_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0046817705002303 DB - PRIME DP - Unbound Medicine ER -