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Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan.
Pharmacol Ther. 2006 Mar; 109(3):325-38.P&T

Abstract

This paper reviews the preclinical and clinical evidence regarding the use of the dietary supplement 5-hydroxytryptophan (5-HTP) for the treatment of depression. In the absence of supplementation with exogenous 5-HTP, the amount of endogenous 5-HTP available for serotonin synthesis depends on the availability of tryptophan and on the activity of various enzymes, especially tryptophan hydroxylase, indoleamine 2,3-dioxygenase, and tryptophan 2,3-dioxygenase (TDO). Factors affecting each of these are reviewed. The amount of 5-HTP reaching the central nervous system (CNS) is affected by the extent to which 5-HTP is converted to serotonin in the periphery. This conversion is controlled by the enzyme amino acid decarboxylase, which, in the periphery, can be blocked by peripheral decarboxylase inhibitors (PDIs) such as carbidopa. Preclinical and clinical evidence for the efficacy of 5-HTP for depression is reviewed, with emphasis on double-blind, placebo-controlled (DB-PC) trials. Safety issues with 5-HTP are also reviewed, with emphasis on eosinophilia myalgia syndrome (EMS) and serotonin syndrome.

Authors+Show Affiliations

Mood Disorders Center, Portland VA Medical Center, Portland, OR 97239, USA. Erick.turner@med.va.govNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16023217

Citation

Turner, Erick H., et al. "Serotonin a La Carte: Supplementation With the Serotonin Precursor 5-hydroxytryptophan." Pharmacology & Therapeutics, vol. 109, no. 3, 2006, pp. 325-38.
Turner EH, Loftis JM, Blackwell AD. Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacol Ther. 2006;109(3):325-38.
Turner, E. H., Loftis, J. M., & Blackwell, A. D. (2006). Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. Pharmacology & Therapeutics, 109(3), 325-38.
Turner EH, Loftis JM, Blackwell AD. Serotonin a La Carte: Supplementation With the Serotonin Precursor 5-hydroxytryptophan. Pharmacol Ther. 2006;109(3):325-38. PubMed PMID: 16023217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serotonin a la carte: supplementation with the serotonin precursor 5-hydroxytryptophan. AU - Turner,Erick H, AU - Loftis,Jennifer M, AU - Blackwell,Aaron D, Y1 - 2005/07/14/ PY - 2005/06/03/received PY - 2005/06/06/accepted PY - 2005/7/19/pubmed PY - 2006/7/6/medline PY - 2005/7/19/entrez SP - 325 EP - 38 JF - Pharmacology & therapeutics JO - Pharmacol. Ther. VL - 109 IS - 3 N2 - This paper reviews the preclinical and clinical evidence regarding the use of the dietary supplement 5-hydroxytryptophan (5-HTP) for the treatment of depression. In the absence of supplementation with exogenous 5-HTP, the amount of endogenous 5-HTP available for serotonin synthesis depends on the availability of tryptophan and on the activity of various enzymes, especially tryptophan hydroxylase, indoleamine 2,3-dioxygenase, and tryptophan 2,3-dioxygenase (TDO). Factors affecting each of these are reviewed. The amount of 5-HTP reaching the central nervous system (CNS) is affected by the extent to which 5-HTP is converted to serotonin in the periphery. This conversion is controlled by the enzyme amino acid decarboxylase, which, in the periphery, can be blocked by peripheral decarboxylase inhibitors (PDIs) such as carbidopa. Preclinical and clinical evidence for the efficacy of 5-HTP for depression is reviewed, with emphasis on double-blind, placebo-controlled (DB-PC) trials. Safety issues with 5-HTP are also reviewed, with emphasis on eosinophilia myalgia syndrome (EMS) and serotonin syndrome. SN - 0163-7258 UR - https://www.unboundmedicine.com/medline/citation/16023217/Serotonin_a_la_carte:_supplementation_with_the_serotonin_precursor_5_hydroxytryptophan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0163-7258(05)00135-X DB - PRIME DP - Unbound Medicine ER -