Tags

Type your tag names separated by a space and hit enter

Anti-gastric ulcer effect of Kaempferia parviflora.
J Ethnopharmacol. 2005 Oct 31; 102(1):120-2.JE

Abstract

Kaempferia parviflora is a Zingiberaceous plant, which has been reputed for its beneficial medicinal effects. The present study was undertaken to evaluate the Kaempferia parviflora ethanolic extract (KPE) for its anti-gastric ulcer activity by experimental models. Oral administration of the KPE at 30, 60 and 120 mg/kg significantly inhibited gastric ulcer formation induced by indomethacin, HCl/EtOH and water immersion restraint-stress in rats. In pylorus-ligated rats, pretreatment with the KPE had no effect on gastric volume, pH and acidity output. In ethanol-induced ulcerated rats, gastric wall mucus was significantly preserved by the KPE pretreatment at doses of 60 and 120 but not at 30 mg/kg. The findings indicate that the ethanolic extract of Kaempferia parviflora possesses gastroprotective potential which is related partly to preservation of gastric mucus secretion and unrelated to the inhibition of gastric acid secretion.

Authors+Show Affiliations

Rujjanawate C
Laboratory of Natural Products, Chulabhorn Research Institute, Research Center at Chiangmai University, Faculty of Medicine, Chiangmai University, Chiangmai 50200, Thailand. crujjana@mail.med.cmu.ac.th
Kanjanapothi D
No affiliation info available
Amornlerdpison D
No affiliation info available
Pojanagaroon S
No affiliation info available

MeSH

AnimalsAnti-Ulcer AgentsMalePhytotherapyPlant ExtractsRatsRats, Sprague-DawleyStomach UlcerZingiberaceae

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16023318

Citation

Rujjanawate, C, et al. "Anti-gastric Ulcer Effect of Kaempferia Parviflora." Journal of Ethnopharmacology, vol. 102, no. 1, 2005, pp. 120-2.
Rujjanawate C, Kanjanapothi D, Amornlerdpison D, et al. Anti-gastric ulcer effect of Kaempferia parviflora. J Ethnopharmacol. 2005;102(1):120-2.
Rujjanawate, C., Kanjanapothi, D., Amornlerdpison, D., & Pojanagaroon, S. (2005). Anti-gastric ulcer effect of Kaempferia parviflora. Journal of Ethnopharmacology, 102(1), 120-2.
Rujjanawate C, et al. Anti-gastric Ulcer Effect of Kaempferia Parviflora. J Ethnopharmacol. 2005 Oct 31;102(1):120-2. PubMed PMID: 16023318.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-gastric ulcer effect of Kaempferia parviflora. AU - Rujjanawate,C, AU - Kanjanapothi,D, AU - Amornlerdpison,D, AU - Pojanagaroon,S, PY - 2005/03/20/received PY - 2005/03/20/accepted PY - 2005/7/19/pubmed PY - 2006/3/17/medline PY - 2005/7/19/entrez SP - 120 EP - 2 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 102 IS - 1 N2 - Kaempferia parviflora is a Zingiberaceous plant, which has been reputed for its beneficial medicinal effects. The present study was undertaken to evaluate the Kaempferia parviflora ethanolic extract (KPE) for its anti-gastric ulcer activity by experimental models. Oral administration of the KPE at 30, 60 and 120 mg/kg significantly inhibited gastric ulcer formation induced by indomethacin, HCl/EtOH and water immersion restraint-stress in rats. In pylorus-ligated rats, pretreatment with the KPE had no effect on gastric volume, pH and acidity output. In ethanol-induced ulcerated rats, gastric wall mucus was significantly preserved by the KPE pretreatment at doses of 60 and 120 but not at 30 mg/kg. The findings indicate that the ethanolic extract of Kaempferia parviflora possesses gastroprotective potential which is related partly to preservation of gastric mucus secretion and unrelated to the inhibition of gastric acid secretion. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/16023318/Anti_gastric_ulcer_effect_of_Kaempferia_parviflora_ DB - PRIME DP - Unbound Medicine ER -