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Virulence differences between monkeypox virus isolates from West Africa and the Congo basin.
Virology. 2005 Sep 15; 340(1):46-63.V

Abstract

Studies indicate that West African and Congo basin isolates of monkeypox virus (MPXV) are genetically distinct. Here, we show Congo basin MPXV-ZAI-V79 is more virulent for cynomolgus monkeys as compared to presumed West African MPXV-COP-58. This finding may explain the lack of case-fatalities in the U.S. 2003 monkeypox outbreak, which was caused by a West African virus. Virulence differences between West African and Congo basin MPXV are further supported by epidemiological analyses that observed a similar prevalence of antibodies in non-vaccinated humans in both regions, while >90% of reported cases occurred in the Congo basin, and no fatal cases were observed outside of this region. To determine the basis for this difference in virulence, we sequenced the genomes of one human West African isolate, and two presumed West African isolates and compared the sequences to Congo basin MPXV-ZAI-96-I-16. The analysis identified D10L, D14L, B10R, B14R, and B19R as possible virulence genes, with D14L (ortholog of vaccinia complement protein) as a leading candidate.

Authors+Show Affiliations

Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, M432, St. Louis, MO 63104, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

16023693

Citation

Chen, Nanhai, et al. "Virulence Differences Between Monkeypox Virus Isolates From West Africa and the Congo Basin." Virology, vol. 340, no. 1, 2005, pp. 46-63.
Chen N, Li G, Liszewski MK, et al. Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Virology. 2005;340(1):46-63.
Chen, N., Li, G., Liszewski, M. K., Atkinson, J. P., Jahrling, P. B., Feng, Z., Schriewer, J., Buck, C., Wang, C., Lefkowitz, E. J., Esposito, J. J., Harms, T., Damon, I. K., Roper, R. L., Upton, C., & Buller, R. M. (2005). Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. Virology, 340(1), 46-63.
Chen N, et al. Virulence Differences Between Monkeypox Virus Isolates From West Africa and the Congo Basin. Virology. 2005 Sep 15;340(1):46-63. PubMed PMID: 16023693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Virulence differences between monkeypox virus isolates from West Africa and the Congo basin. AU - Chen,Nanhai, AU - Li,Guiyun, AU - Liszewski,M Kathryn, AU - Atkinson,John P, AU - Jahrling,Peter B, AU - Feng,Zehua, AU - Schriewer,Jill, AU - Buck,Charles, AU - Wang,Chunlin, AU - Lefkowitz,Elliot J, AU - Esposito,Joseph J, AU - Harms,Tiara, AU - Damon,Inger K, AU - Roper,Rachel L, AU - Upton,Chris, AU - Buller,R Mark L, PY - 2005/03/14/received PY - 2005/04/23/revised PY - 2005/05/25/accepted PY - 2005/7/19/pubmed PY - 2005/11/9/medline PY - 2005/7/19/entrez SP - 46 EP - 63 JF - Virology JO - Virology VL - 340 IS - 1 N2 - Studies indicate that West African and Congo basin isolates of monkeypox virus (MPXV) are genetically distinct. Here, we show Congo basin MPXV-ZAI-V79 is more virulent for cynomolgus monkeys as compared to presumed West African MPXV-COP-58. This finding may explain the lack of case-fatalities in the U.S. 2003 monkeypox outbreak, which was caused by a West African virus. Virulence differences between West African and Congo basin MPXV are further supported by epidemiological analyses that observed a similar prevalence of antibodies in non-vaccinated humans in both regions, while >90% of reported cases occurred in the Congo basin, and no fatal cases were observed outside of this region. To determine the basis for this difference in virulence, we sequenced the genomes of one human West African isolate, and two presumed West African isolates and compared the sequences to Congo basin MPXV-ZAI-96-I-16. The analysis identified D10L, D14L, B10R, B14R, and B19R as possible virulence genes, with D14L (ortholog of vaccinia complement protein) as a leading candidate. SN - 0042-6822 UR - https://www.unboundmedicine.com/medline/citation/16023693/Virulence_differences_between_monkeypox_virus_isolates_from_West_Africa_and_the_Congo_basin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0042-6822(05)00330-2 DB - PRIME DP - Unbound Medicine ER -