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Vocal process granuloma of the larynx-recognition, differential diagnosis and treatment.
Oral Oncol. 2005 Aug; 41(7):666-9.OO

Abstract

The vocal process granuloma is a nonneoplastic lesion that most often develops in the vicinity of the posterior vocal cords, adjacent to the vocal process. It may be an ulcerated region of the cord, or it may manifest as a nodular polypoid lesion. Causative factors include gastroesophageal reflux, intubation trauma, and vocal abuse. This lesion may be mistaken on clinical or pathologic grounds for carcinoma, although thorough microscopic examination usually permits a correct diagnosis. Despite its name, vocal process granuloma is not a true granulomatous process in a pathologic sense (inasmuch as it lacks aggregates of mononuclear and multinucleated histiocytes)-rather, it is a reactive/reparative process, in which an intact or ulcerated squamous epithelium is underlaid by granulation tissue or fibrosis. Treatment of vocal process granuloma centers around conservative voice therapy, coupled with treatment of any underlying inciting cause (such as gastroesophageal reflux). While it may recur locally (particularly if the original inciting cause persists), vocal process granuloma has no premalignant potential.

Authors+Show Affiliations

Department of Pathology, Foote Hospital, Jackson, MI, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16023983

Citation

Devaney, Kenneth O., et al. "Vocal Process Granuloma of the Larynx-recognition, Differential Diagnosis and Treatment." Oral Oncology, vol. 41, no. 7, 2005, pp. 666-9.
Devaney KO, Rinaldo A, Ferlito A. Vocal process granuloma of the larynx-recognition, differential diagnosis and treatment. Oral Oncol. 2005;41(7):666-9.
Devaney, K. O., Rinaldo, A., & Ferlito, A. (2005). Vocal process granuloma of the larynx-recognition, differential diagnosis and treatment. Oral Oncology, 41(7), 666-9.
Devaney KO, Rinaldo A, Ferlito A. Vocal Process Granuloma of the Larynx-recognition, Differential Diagnosis and Treatment. Oral Oncol. 2005;41(7):666-9. PubMed PMID: 16023983.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vocal process granuloma of the larynx-recognition, differential diagnosis and treatment. AU - Devaney,Kenneth O, AU - Rinaldo,Alessandra, AU - Ferlito,Alfio, PY - 2004/11/04/received PY - 2004/11/15/accepted PY - 2005/7/19/pubmed PY - 2006/1/18/medline PY - 2005/7/19/entrez SP - 666 EP - 9 JF - Oral oncology JO - Oral Oncol VL - 41 IS - 7 N2 - The vocal process granuloma is a nonneoplastic lesion that most often develops in the vicinity of the posterior vocal cords, adjacent to the vocal process. It may be an ulcerated region of the cord, or it may manifest as a nodular polypoid lesion. Causative factors include gastroesophageal reflux, intubation trauma, and vocal abuse. This lesion may be mistaken on clinical or pathologic grounds for carcinoma, although thorough microscopic examination usually permits a correct diagnosis. Despite its name, vocal process granuloma is not a true granulomatous process in a pathologic sense (inasmuch as it lacks aggregates of mononuclear and multinucleated histiocytes)-rather, it is a reactive/reparative process, in which an intact or ulcerated squamous epithelium is underlaid by granulation tissue or fibrosis. Treatment of vocal process granuloma centers around conservative voice therapy, coupled with treatment of any underlying inciting cause (such as gastroesophageal reflux). While it may recur locally (particularly if the original inciting cause persists), vocal process granuloma has no premalignant potential. SN - 1368-8375 UR - https://www.unboundmedicine.com/medline/citation/16023983/Vocal_process_granuloma_of_the_larynx_recognition_differential_diagnosis_and_treatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1368-8375(04)00257-X DB - PRIME DP - Unbound Medicine ER -