Tags

Type your tag names separated by a space and hit enter

Oxidative stress and acute-phase response in patients with pressure sores.
Nutrition. 2005 Sep; 21(9):901-7.N

Abstract

OBJECTIVE

We investigated the relation between oxidative stress and the occurrence of the acute-phase response with serum ascorbic acid and alpha-tocopherol levels in patients with pressure sores.

METHODS

The following groups of patients were studied: 1) those who had patients with pressure sores, 2) those who had pneumonia, and 3) those who did not develop pressure sores or any type of infection (control). Concentrations of total proteins, albumin, creatinine, iron, ferritin, transferrin, C-reactive protein, alpha1-acid glycoprotein, total iron-binding capacity, ascorbic acid, alpha-tocopherol, and malondialdehyde were measured during the first days of hospitalization.

RESULTS

Albumin concentrations were significantly lower (P < 0.05) and C-reactive protein concentrations were significantly higher (P < 0.05) in patients with pressure sores compared with controls. Concentrations of ascorbic acid and alpha-tocopherol were significantly decreased (P < 0.05) in patients who had pressure sores or infection, whereas malondialdehyde concentrations were significantly increased (P < 0.05) compared with control patients. Five of 11 patients (55.56%) with pressure sores and 10 of 12 patients (83.33%) with pneumonia presented serum ascorbic acid concentrations below the reference value (34 to 91 micromol/L). Concentrations of ascorbic acid and alpha-tocopherol versus malondialdehyde were significantly correlated in the three patient groups (r = -0.44, P < 0.05; r = -0.55, P < 0.01, respectively).

CONCLUSION

Patients with pressure sores and acute infection present a systemic inflammatory response accompanied by an increase in lipid peroxidation that is associated with decreased serum ascorbic acid and alpha-tocopherol levels, suggesting that these patients may be at risk for important nutritional deficiencies.

Authors+Show Affiliations

Department of Internal Medicine, School Medicine of Triângulo Mineiro, Uberaba, Brazil. mbcfmtm@mednet.com.brNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16024223

Citation

Cordeiro, Maria Bernarda Cavalcanti, et al. "Oxidative Stress and Acute-phase Response in Patients With Pressure Sores." Nutrition (Burbank, Los Angeles County, Calif.), vol. 21, no. 9, 2005, pp. 901-7.
Cordeiro MB, Antonelli EJ, da Cunha DF, et al. Oxidative stress and acute-phase response in patients with pressure sores. Nutrition. 2005;21(9):901-7.
Cordeiro, M. B., Antonelli, E. J., da Cunha, D. F., Júnior, A. A., Júnior, V. R., & Vannucchi, H. (2005). Oxidative stress and acute-phase response in patients with pressure sores. Nutrition (Burbank, Los Angeles County, Calif.), 21(9), 901-7.
Cordeiro MB, et al. Oxidative Stress and Acute-phase Response in Patients With Pressure Sores. Nutrition. 2005;21(9):901-7. PubMed PMID: 16024223.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oxidative stress and acute-phase response in patients with pressure sores. AU - Cordeiro,Maria Bernarda Cavalcanti, AU - Antonelli,Elida Juliana, AU - da Cunha,Daniel Ferreira, AU - Júnior,Alceu Afonso Jordão, AU - Júnior,Virmondes Rodrigues, AU - Vannucchi,Helio, PY - 2004/10/30/received PY - 2005/01/05/accepted PY - 2005/7/19/pubmed PY - 2006/1/27/medline PY - 2005/7/19/entrez SP - 901 EP - 7 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 21 IS - 9 N2 - OBJECTIVE: We investigated the relation between oxidative stress and the occurrence of the acute-phase response with serum ascorbic acid and alpha-tocopherol levels in patients with pressure sores. METHODS: The following groups of patients were studied: 1) those who had patients with pressure sores, 2) those who had pneumonia, and 3) those who did not develop pressure sores or any type of infection (control). Concentrations of total proteins, albumin, creatinine, iron, ferritin, transferrin, C-reactive protein, alpha1-acid glycoprotein, total iron-binding capacity, ascorbic acid, alpha-tocopherol, and malondialdehyde were measured during the first days of hospitalization. RESULTS: Albumin concentrations were significantly lower (P < 0.05) and C-reactive protein concentrations were significantly higher (P < 0.05) in patients with pressure sores compared with controls. Concentrations of ascorbic acid and alpha-tocopherol were significantly decreased (P < 0.05) in patients who had pressure sores or infection, whereas malondialdehyde concentrations were significantly increased (P < 0.05) compared with control patients. Five of 11 patients (55.56%) with pressure sores and 10 of 12 patients (83.33%) with pneumonia presented serum ascorbic acid concentrations below the reference value (34 to 91 micromol/L). Concentrations of ascorbic acid and alpha-tocopherol versus malondialdehyde were significantly correlated in the three patient groups (r = -0.44, P < 0.05; r = -0.55, P < 0.01, respectively). CONCLUSION: Patients with pressure sores and acute infection present a systemic inflammatory response accompanied by an increase in lipid peroxidation that is associated with decreased serum ascorbic acid and alpha-tocopherol levels, suggesting that these patients may be at risk for important nutritional deficiencies. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/16024223/Oxidative_stress_and_acute_phase_response_in_patients_with_pressure_sores_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(05)00165-6 DB - PRIME DP - Unbound Medicine ER -